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Patrick Mahomes and Kyler Murray will square off in a Week 1 battle when the Arizona Cardinals host the Kansas City Chiefs on Sunday. The home team is trying to put a disappointing end to their 2021 campaign behind them, but enter the new season with injuries already peppering their lineup. Meanwhile, Kansas City is out to prove its offense is still a force to be reckoned with, even though star wide receiver Tyreek Hill left in the offseason. You can stream the game in select markets on Paramount+.

Kickoff from University of Phoenix Stadium in Glendale, Arizona is set for 4:25 p.m. ET on Sunday. The Chiefs are six-point favorites in the latest Cardinals vs. Chiefs odds from Caesars Sportsbook, and the over/under for total points is 53.5. In select markets, Sunday's matchup can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan.

Paramount+ now has levels of membership so you can watch your local NFL on CBS matchups and much more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream, including plenty of sports like SEC on CBS, NFL on CBS, and the PGA Tour, with no ads, on demand and the ability to download episodes for offline viewing. Both plans come with a free week to start and include the NFL on CBS, so sign up now here.

How to watch Chiefs vs. Cardinals

  • Chiefs vs. Cardinals date: Sunday, Sept. 11
  • Chiefs vs. Cardinals time: 4:25 p.m. ET
  • Chiefs vs. Cardinals TV: CBS 
  • Chiefs vs. Cardinals streaming: Paramount+

Week 1 NFL picks for Cardinals vs. Chiefs

Before tuning into Sunday's Cardinals vs. Chiefs game, you need to see the NFL picks from SportsLine's advanced computer model. The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

For Cardinals vs. Chiefs, the model is picking Arizona to cover the spread. The Chiefs are 4-0 in Week 1 with Patrick Mahomes under center, but this will be his first start without Hill to connect with downfield. While Kansas City's offense is capable of getting the job done, they may still be a few weeks away from working out all of the kinks and steamrolling the competition.

Meanwhile, Arizona is dealing with a plethora of injuries to open up the season. The Cardinals had tight end Zach Ertz back at practice on Friday after he was sidelined with a calf injury, but Arizona's offense is still depleted with receivers Antoine Wesley (hip/groin) and DeAndre Hopkins (suspension) out for Week 1, while Rondale Moore a game-time decision on Sunday because of a hamstring injury. Arizona could also potentially be without star defensive end J.J. Watt, who missed practice this week due to a calf injury. Kingsbury called him a game-time decision on Friday.

How to watch, live stream the NFL on CBS

Now that you know what to pick, get ready to watch your live local NFL on CBS games on Paramount+ on any device you want. Visit Paramount+ now to stream your live local CBS sporting events, including the NFL, SEC on CBS, and so much more