The Arizona Cardinals and the Seattle Seahawks will face off in an NFC West clash at 4:25 p.m. ET on Sunday at Lumen Field. Seattle is 3-6 overall and 1-3 at home, while the Cardinals are 8-2 overall and 5-0 on the road. The Cardinals have lost two of their last three games. The Seahawks have lost four of their past five games. 

The Seahawks and Cardinals split their two meetings in 2020. Arizona is favored by one point in the latest Seahawks vs. Cardinals odds from Caesars Sportsbook, and the over-under is set at 47.5. Before entering any Cardinals vs. Seahawks picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 11 of the 2021 season on an incredible 128-89 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Seahawks vs. Cardinals. You can head to SportsLine to see its picks. Here are several NFL betting lines for Cardinals vs. Seahawks:

  • Seahawks vs. Cardinals spread: Cardinals -1
  • Seahawks vs. Cardinals over-under: 47.5 points

What you need to know about the Seahawks

The Seahawks were blanked by the Packers in Week 11, 17-0. It was the first time Seattle was shut out in Russell Wilson's career. In his return from a three-game layoff because of a finger injury, Wilson threw two interceptions with only 161 yards passing. DK Metcalf and Tyler Lockett combined for just 49 receiving yards. 

Alex Collins led the Seahawks with 41 yards on 10 carries. Collins (groin) is expected to play on Sunday. Chris Carson will undergo neck surgery and is out for the season. 

What you need to know about the Cardinals

Meanwhile, the Cardinals took a 34-10 loss to the Carolina Panthers last week. Kyler Murray has not played since Week 8 because of an ankle injury. He is a game-time decision for Week 11. Colt McCoy and Chris Streveler combined for just 143 passing yards against Carolina. 

The Cardinals totaled just 169 yards vs. Carolina. DeAndre Hopkins (hamstring) is out for Week 11. James Conner has rushed for six TDs in his past four games. 

How to make Cardinals vs. Seahawks picks

The model is leaning under on the total, and it also has generated a pick that hits in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Seahawks vs. Cardinals? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.