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The Minnesota Vikings kicked off their 2021 season on the road against Cincinnati Bengals and lost in overtime. They'll get a shot at redemption on Sunday against one of the NFL's strongest teams. The Arizona Cardinals will host Minnesota at State Farm Field in hopes of improving to 2-0 on the season. The offensive talents on both sides could make for an exciting matchup that could sail past the over.

Kickoff is set for 4:05 p.m. ET. Arizona is a 3.5-point favorite in the latest Vikings vs. Cardinals odds from Caesars Sportsbook, while the over-under for total points scored is 50.5. Before locking in any Cardinals vs. Vikings picks, make sure you check out the latest NFL predictions and analysis from SportsLine's proven computer projection model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Vikings on Sunday and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Here are the NFL odds and betting trends for Vikings vs. Cardinals:

  • Vikings vs. Cardinals spread: Arizona -3.5
  • Vikings vs. Cardinals over-under: 50.5 points
  • Vikings vs. Cardinals money line: Arizona -200, Minnesota +170
  • MIN: Vikings are 5-1 straight-up in their last five games against the Cardinals
  • ARI: Cardinals were 7-9 against the spread last season
Featured Game | Arizona Cardinals vs. Minnesota Vikings

Why the Vikings can cover

The Vikings were favored by three points ahead of Week 1 but fell short by three points. They were respectable 7-9 against the spread last season. The total has gone under in four of Minnesota's last five games at Arizona. The visitors have enough firepower to keep pace with the Cardinals in a low-scoring game.

Arizona's defense shocked the masses by bottling up Tennessee's usually prolific offense in Week 1. However, being just as effective against another very talented offense will be tough. Justin Jefferson, Adam Thielen, and Dalvin Cook powered a unit that ranked fourth in yards per game in 2020. That production is plenty threatening. 

Why the Cardinals can cover

Kyler Murray's shoulder injury derailed a promising Cardinals season in 2020. The star quarterback's electric playmaking helped Arizona cover the spread five times last year in their first seven games. The Cardinals fell short in seven of their final nine games, but they're healthy this time around.

Cincinnati put up 27 points on a Minnesota team that went 4-4 on the road last year, and the Vikings lost three of those games by double-digits. Arizona handily covered the spread last week, demolishing Tennessee by 25 as a 2.5-point underdog.

How to make Vikings vs. Cardinals picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 52 points. It also says one side of the spread hits almost 60 percent of the time. You can only get the model's picks at SportsLine.

So who wins Cardinals vs. Vikings on Sunday? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to see which side of the Vikings vs. Cardinals spread to be all over on Sunday, all from the advanced model that is up almost $7,900 on its top-rated NFL picks, and find out.