The Arizona Cardinals go on the road for the first time in the 2019 NFL preseason when they face the Minnesota Vikings on Saturday afternoon. Kickoff is scheduled for 1 p.m. ET from U.S. Bank Stadium. First-year coach Kliff Kingsbury said the team will play with a greater sense of urgency following last week's 33-26 home loss to the Oakland Raiders in which it faced a 26-0 deficit. Conversely, the Vikings aim to keep their momentum going on the heels of a 2-0 start that included last week's 25-19 home win over the Seattle Seahawks. The Vikings hold a 16-11 all-time edge in the series, including two playoff victories. Minnesota is a six-point sportsbook favorite and the over-under for total points scored is 43.5 in the latest Cardinals vs. Vikings odds. Before locking in your Cardinals vs. Vikings picks, make sure you see the NFL preseason predictions from Zack Cimini.

Cimini is a highly respected Las Vegas handicapper who's never afraid to buck conventional wisdom. He uses a new-age approach to excel in multiple sports and has been one of SportsLine's most successful analysts on an annual basis.

Last season, he hit 60 percent of his NFL picks for SportsLine members. Over the past two seasons, Cimini is 10-2 on NFL against the spread picks involving the Cardinals or Vikings, including a 5-0 mark on Arizona. Last year, he advised SportsLine members that Arizona was overvalued as a 4.5-point home favorite against the Oakland Raiders. The result: Oakland pulled off an outright 23-21 victory, and anyone who followed Cimini's advice booked another easy winner. Those who have consistently followed him are way up.

Now, he's locked in his Cardinals vs. Vikings picks for Saturday. You can only see them at SportsLine.

Cimini knows the Vikings are leading the NFL this preseason with an average of 433 yards of offense per game. Coming off a season in which they ranked No. 20 on the league in total offense, coach Mike Zimmer has decided to go with an up-tempo approach. Zimmer told the media he has been pleased with the execution by Cousins through the first two games.

Cousins played one series in a 34-25 win at New Orleans in Week 1 and two in last week's win over Seattle. In leading the Vikings to 10 total points, he has completed 10 of 12 passes for 133 yards and a touchdown with a passer rating of 140.6. Zimmer said the first-team offense could play the majority of the first half Saturday. 

Even so, Minnesota is far from assured of covering the Vikings vs. Cardinals spread against an Arizona team that will be determined to bounce back from the growing pains it experienced last week.

Top overall draft pick Kyler Murray should benefit from extended playing time on Saturday and, on the bright side, his backups stepped up and mounted a second-half comeback that brought the Cardinals to within one score. They outscored the Raiders 16-7 in the second half.

Veteran Brett Hundley threw for 139 yards on 10-of-15 attempts with a touchdown. Chad Kanoff and Drew Anderson combined for 124 yards and each threw a scoring pass. Thirteen different players caught passes and the unit just received a boost from the signing of veteran Michael Crabtree, who could see action Saturday.

Cimini has broken down the depth charts of both teams and unearthed the critical X-factor that has him leaning hard to one side of the spread. You can only see what it is, and which team to back, at SportsLine.

Who wins Vikings vs. Cardinals? And what critical factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Vikings vs. Cardinals spread you should jump on Saturday, all from the seasoned NFL expert who has hit 83 percent of his picks involving these teams, and find out.