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Kim Klement-USA TODAY Sports

The Los Angeles Chargers look for a huge upset when they make their debut at SoFi Stadium against the Kansas City Chiefs on Sunday afternoon. The Chargers escaped with a 16-13 victory at Cincinnati in the season opener last Sunday, watching as the Bengals' Randy Bullock missed a 31-yard field goal that would have tied it with two seconds left. The home-field advantage will be tempered with no fans in attendance, but the glistening new venue should provide a spark for Los Angeles. The defending Super Bowl champion Chiefs kicked off their season with a 34-20 victory against the Texans

Kickoff is set for 4:25 p.m. ET at SoFi Stadium in Los Angeles. Kansas City is an 8.5-point favorite in the latest Chiefs vs. Chargers odds at William Hill, while the over-under is 47. Before you make any Chargers vs. Chiefs picks of your own, be sure to check out the latest NFL predictions from the SportsLine Projection Model.

The SportsLine Projection Model, which simulates every NFL game 10,000 times, is up over $7,400 for $100 players on its top-rated NFL picks since its inception five years ago. It went a perfect 4-0 on top-rated NFL picks in Week 1, including calling easy covers by the Ravens and Bills. The model enters Week 2 on an incredible 100-65 roll on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Chiefs vs. Chargers. You can visit SportsLine now to see the picks. Here are the NFL odds from William Hill and trends for Chargers vs. Chiefs:

  • Chiefs vs. Chargers spread: Kansas City: -8.5
  • Chiefs vs. Chargers over-under: 47
  • Chiefs vs. Chargers money line: Kansas City -410, Los Angeles +330 
  • KC: TE Travis Kelce had at least three receptions in all 19 games last season
  • LAC: RB Austin Ekeler topped 60 receiving yards eight times last season.

Why the Chiefs can cover

The road team is 12-3-1 against the spread in the last 16 meetings between the teams. Edwards-Helaire ran for 138 yards and a touchdown in his debut, while Kelce, Sammy Watkins and Tyreek Hill also scored in the victory. Mahomes threw for just 211 yards, but had three TD passes and no interceptions, completed 75 percent of his attempts and was sacked just once.

The Chiefs are 8-3-1 against the spread in division games since 2018, and the defense made major strides late last season. The unit allowed 10.4 points per game over its last five in 2019, and the front can cause plenty of trouble for quarterbacks. Safety Tyrann Mathieu is the soul of the unit, and he had eight tackles to lead the team in the opener.

Why the Chargers can cover

Los Angeles is 7-4-2 against the spread as an underdog since 2018, and the Chargers' defense could make things tough for Patrick Mahomes. The unit is stout up front, with Joey Bosa and Melvin Ingram leading the way. Bosa had one of the team's three sacks in the opener after posting 11.5 last season, and Ingram had an interception last Sunday. The unit also has depth at linebacker, led by Denzel Perryman, who forced a critical fumble in Los Angeles' 16-13 victory in Week 1.  

The Chargers are 2-2 against the spread as a home underdog since moving back to L.A. in 2017, and quarterback Tyrod Taylor has talent to work with. Receivers Keenan Allen and Mike Williams both eclipsed 1,000 yards in 2019, and running back Austin Ekeler had 92 receptions for 993 yards. Tight end Hunter Henry is a valuable outlet, and he had a team-high 73 yards in Week 1. Ekeler rushed for 84 yards, and rookie Joshua Kelley had 60 and scored the only touchdown last week.

How to make Chiefs vs. Chargers picks

SportsLine's model is leaning over on the total, as Mahomes throws for more than 275 yards and Ekeler approaches 100 total yards. It also says one side of the spread cashes in nearly 60 percent of simulations. You can only get the pick at SportsLine

So who wins Chargers vs. Chiefs? And which side of the spread is hitting almost 60 percent of the time? Visit SportsLine now to see which side of the Chiefs vs. Chargers spread to jump on, all from the advanced model that is up more than $7,400 on its top-rated NFL picks, and find out.