The Dallas Cowboys will try to build on last week's success when they host the Arizona Cardinals on Monday Night Football. Despite losing quarterback Dak Prescott (ankle) for the year, the Cowboys (2-3) were able to rally behind veteran Andy Dalton to defeat the New York Giants, 27-24. Dallas is playing under the leadership of coach Mike McCarthy, who took over during the offseason after posting a 135-85-2 record in more than 12 seasons with the Green Bay Packers. Arizona is led by second-year coach Kliff Kingsbury, who was 5-10-1 in 2019.

Kickoff from AT&T Stadium is set for 8:15 p.m. ET, and Dallas leads the all-time series 56-31-1. The Cowboys are one-point favorites in the latest Cowboys vs. Cardinals odds from William Hill after the line opened at -3, while the over-under is 55. Before making any Cardinals vs. Cowboys picks, check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up. 

Now, the model has set its sights on Cardinals vs. Cowboys. You can visit SportsLine now to see the picks. Here are the NFL lines and trends for Cowboys vs. Cardinals:

  • Cowboys vs. Cardinals spread: Cowboys -1
  • Cowboys vs. Cardinals over-under: 55 points
  • Cowboys vs. Cardinals money line: Cowboys -120, Cardinals +100
  • ARI: 16th in the NFL in points per game at 25.6
  • DAL: 0-5 against the spread this season

Why the Cardinals can cover

Kyler Murray continues to hone his skills and is fast becoming one of the top quarterbacks in the game. For the season, Murray has been sharp, completing 126 of 181 passes for 1,299 yards and eight touchdowns. He has been picked off six times, but still has a rating of 90.9. He has been red-hot in October, completing 75 percent of his passes for 513 yards and four touchdowns and a 109.5 rating.

Also making an impact is running back Chase Edmonds, who had 92 yards from scrimmage, including 56 receiving, and a rushing touchdown last week against the Jets. He is looking for his third road game in a row with five or more catches and a TD. For the season, he has carried 19 times for 95 yards and one touchdown with two explosive plays and seven first-down conversions. He also has 18 receptions out of the backfield for 129 yards and two more scores.

Why the Cowboys can cover

Wide receiver Michael Gallup is coming off a strong game against the New York Giants and will look to duplicate that success this week. He now has 50-plus receiving yards in six of his past seven games after a 4-73 performance. For the season, Gallup has 17 receptions for 348 yards and one touchdown. He has six explosive plays of 20 or more yards and has converted 14 first downs.

Also playing a key role is tight end Dalton Schultz, who is fourth on the team in receptions with 19 for 225 yards and two TDs after the departure of longtime Cowboy Jason Witten, who is now with the Las Vegas Raiders. Schultz has three explosive plays with 13 first-down conversions.

How to make Cowboys vs. Cardinals picks

SportsLine's model is leaning under the total. In fact, it says Murray will pass for fewer than 250 yards, while Elliott won't eclipse the 100-yard rushing mark. It has also generated a very strong against-the-spread pick that cashes in over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Cardinals vs. Cowboys on Monday Night Football? And which side of the spread cashes in more than 60 percent of simulations? Visit SportsLine now to see which side of the Cardinals vs. Cowboys spread to jump on, all from the advanced model that is up well over $7,500 on its NFL picks, and find out.