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The Dallas Cowboys will be on the road for the first time this season when they visit MetLife Stadium to face the New York Giants on Monday Night Football. The Cowboys split their two home games to start the 2022 NFL season, losing 19-3 to the Tampa Bay Buccaneers before beating the Bengals 20-17 on a last-minute drive Sunday. Quarterback Dak Prescott was injured in that loss to Tampa Bay and is out after having surgery, but Cooper Rush did enough to get the victory against Carolina. The Giants are 2-0 for the first time since 2016 and bring confidence into the NFC East showdown. They started off the season with a 21-20 victory against Tennessee, the AFC's top seed in the playoffs last season. They followed that with a 19-13 victory against Carolina on Sunday, and new coach Brian Daboll seems to have instilled fight into a team that went 4-13 in 2021.

Kickoff is set for 8:15 p.m. ET at MetLife Stadium in East Rutherford, N.J. Caesars Sportsbook lists New York as a 1-point favorite in its latest Cowboys vs. Giants odds, and the over/under for total points scored is 39.5. Before you lock in any Giants vs. Cowboys picks, you have to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has broken down Monday's Cowboys vs. Giants matchup and just locked in its picks and MNF predictions. You can head to SportsLine now to see the model's picks. Here are the NFL odds and betting lines for Giants vs. Cowboys:  

  • Cowboys vs. Giants spread: New York -1 
  • Cowboys vs. Giants over/under: 39.5 points 
  • Cowboys vs. Giants money line: Dallas -105, New York -115 
  • DAL: Cowboys were 8-1 ATS on the road last season 
  • NYG: Giants were 3-5 ATS in their 2021 home games 
  • Cowboys vs. Giants picks: See picks here

Why the Giants can cover

The Giants have just been finding ways to win under Daboll, and the longtime Patriots offensive assistant is riding with a healthy Saquon Barkley. The former No. 2 overall pick led the league with 236 rushing yards entering Week 3 and has rushed for more than 70 in consecutive weeks. New York has attempted the third-fewest passes in the league (55) and is tied for fifth-most rushing attempts (65). The run and play defense model are its likeliest path to success against the Cowboys, who rank sixth in the league against the pass but 20th against the run.

The Giants' defense, and the New York crowd, will try to rattle Cooper Rush in his third start, and the QB has completed just 59 percent of his throws. The Giants have been particularly stout on third downs, allowing opponents to convert just 22 percent of the time, the best mark in the league. The Cowboys' offense is tied for the worst mark, getting a first down just 24 percent of the time. Micah Parsons, who has four sacks (and 17 sacks in 18 career games), will be after Jones all night, and Trevon Diggs had an interception in both meetings last season.

Why the Cowboys can cover

Dallas has been the best team in the NFL against the spread since the start of last season, going 14-5. They are 8-2 against the number in the past 10 meetings with the Giants, winning nine straight-up. Rush has led fourth-quarter comebacks to win both of his career starts and is surrounded by talented players. Ezekiel Elliott has scored in four straight against the Giants and averages almost 94 total yards in 10 starts against them. Noah Brown has emerged as one of Rush's favorite targets, leading the team with 10 receptions. He had a team-high 91 yards last week.

Tony Pollard also is a critical piece of the offense and had 98 total yards in Week 2. The Cowboys' pass rush was relentless last week against the Bengals, sacking Joe Burrow six times. Micah Parsons has four of the team's eight sacks (third in NFL) and will be chasing Jones all night. The Giants quarterback, who is 0-8 in his career in prime time, was sacked 22 times in 11 games last season.

How to make Cowboys vs. Giants picks

The model has broken down Monday night's Giants vs. Cowboys matchup from all angles. It is leaning Over on the point total, suggesting both teams will find success in the running game. The model also says one side has all the value. You can only get the model's MNF picks at SportsLine.

So who wins Giants vs. Cowboys on Monday Night Football? And which side of the spread has all the value? Visit SportsLine right now to find out which side of the Giants vs. Cowboys spread you should be all over Monday, all from the model on a 139-102 roll on its top-rated NFL picks, and find out.