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The first matchup of the Week 5 NFL schedule will take place in London, England. The New York Jets and Atlanta Falcons will face off in an interconference matchup between 1-3 teams on Sunday. Rookie quarterback Zach Wilson and the Jets are looking to build on their first win of the season, while the Matt Ryan and the Falcons will hope to rebound from a close loss to the Washington Football Team. Falcons star wide receiver Calvin Ridley is out with a personal issue.

Kickoff is set for 9:30 a.m. ET. Atlanta is a 2.5-point favorite in the latest Jets vs. Falcons odds from Caesars Sportsbook, while the Over-Under is 45. Before locking in your Jets vs. Falcons picks and NFL Week 5 predictions, make sure you check out the NFL analysis and betting insight from the SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick 'em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated Jets vs. Falcons 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Jets vs. Falcons:

  • Jets vs. Falcons spread: Atlanta -2.5
  • Jets vs. Falcons over-under: 45
  • Jets vs. Falcons money line: Atlanta -145, New York +125 
  • NYJ: Jets are 2-1 against the spread in their last three games against the Falcons  
  • ATL: Falcons are 5-2 straight-up in their last seven games against the Jets 

Why the Jets can cover 

New York is only 1-3 against the spread this year, but could take a step in the right direction on Sunday. The Jets covered as six-point underdogs with a 27-24 win over the banged-up Tennessee Titans in Week 4 to gain momentum. Playing on a neutral field could help them against a Falcons team that's struggling to stop opposing squads from scoring.

The Falcons' offense has started to bounce back, but they have the worst scoring defense in the NFL through Week 4. They've given up a league-high 128 points, and only nine teams have given up more yards per game. New York could stay close if it builds upon its Week 4 performance.

Why the Falcons can cover

The Falcons are 1-3 against the spread and straight-up, and their defense has a lot to do with that. They've given up more points than any team in the NFL through Week 4. However, the Jets have the NFL's lowest-scoring offense and could struggle to put points on the board.

New York has tallied a league-low 47 points in 2021 and ranks 29th in total yards. Wilson's questionable decision-making has led to a league-high eight interceptions. His lack of a go-to guy could lead to his downfall against a much more experienced Falcons side.

Ryan has amassed 526 yards and six touchdowns without a pick since Week 3. He's benefited from having touchdown machine Cordarrelle Patterson at his disposal. The wideout-running back hybrid has racked up 354 yards from scrimmage and five touchdowns.

How to make Jets vs. Falcons picks 

SportsLine's model is leaning under on the total, projecting the teams to combine for 41 points. It has also locked in a Jets vs. Falcons against the spread pick that hits in almost 60 percent of simulations. You can only see the model's Jets vs. Falcons picks at SportsLine.

So, who wins Jets vs. Falcons in London? And which side of the spread cashes in nearly 60 percent of simulations? Visit SportsLine now to see which side of the Jets vs. Falcons spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and find out.