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The Arizona Cardinals will take on the Detroit Lions at 4:25 p.m. ET on Sunday at State Farm Stadium. The Cardinals are 2-0 and Detroit is 0-2. Arizona is favored by 5.5 points in the latest Cardinals vs. Lions odds from William Hill, and the over-under is set at 55.5. Before entering any Lions vs. Cardinals picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,300 for $100 players on its top-rated NFL picks since its inception five-plus years ago. It's off to a strong 5-2 roll on top-rated NFL picks this season. The model enters Week 3 on an incredible 101-67 roll on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Lions. You can head to SportsLine to see its picks. Here are several NFL betting lines for Lions vs. Cardinals:

  • Cardinals vs. Lions spread: Cardinals -5.5
  • Cardinals vs. Lions over-under: 55.5 points
  • Cardinals vs. Lions money line: Arizona -240, Detroit +200

What you need to know about the Cardinals

Arizona scored a 30-15 victory over the Washington Football Team. Kyler Murray passed for 286 yards and a touchdown and had 67 rushing yards and two scores last week. He is the first QB with 500-plus passing yards and 150-plus rushing yards in his first two games in the Super Bowl era. DeAndre Hopkins led the team with eight receptions for 68 yards and TD catch last week. His 22 catches in the first two weeks are the most by any player in his first two games with a new team in NFL history. 

Kenyan Drake has five rushing TDs in five home games with Arizona. Jordan Hicks had 10 tackles in Week 2. He had 14 tackles in the last meeting in 2019.  

What you need to know about the Lions

Meanwhile, the Lions took a 42-21 loss to the Green Bay Packers last Sunday. Detroit was down 34-14 at the end of the third quarter. The Lions played the Cardinals to a 27-27 tie in early September of 2019. Matthew Stafford passed for 385 yards and three touchdowns with no interceptions in that game. Since 2018, he has 21 TDs vs. four INTs in 13 road starts.

Kenny Golladay has not played this season because of a hamstring injury and is questionable for Week 3. T.J. Hockenson had six catches for 131 yards and TD in his NFL debut when the teams met last year. Jeff Okudah led the team with seven tackles in his NFL debut last week.

How to make Lions vs. Cardinals picks

The model has simulated Cardinals vs. Lions 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Lions vs. Cardinals? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Lions vs. Cardinals spread to jump on Sunday, all from the model that enters Week 3 of the NFL season on an incredible 101-67 roll.