Two teams looking for a spark meet in Week 6 when the Detroit Lions visit the Jacksonville Jaguars. Kickoff is set for 1 p.m. ET at TIAA Bank Field. The Lions enter Sunday's showdown averaging 24.8 points per game this season. Jacksonville, meanwhile, is giving up an average of 416.8 yards per game on defense, which ranks 30th in the NFL.

Detroit is a three-point road favorite in the latest Lions vs. Jaguars odds from William Hill, up a point from the opening line. The over-under for total points expected is 54. Before making any Jaguars vs. Lions picks, be sure to see the Week 6 NFL predictions from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 10-5 roll on top-rated picks this season. The model enters Week 6 on an incredible 106-70 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Jaguars vs. Lions. You can head to SportsLine to see its picks. Here are several NFL betting lines for Lions vs. Jaguars:

  • Jaguars vs. Lions spread: Jaguars +3
  • Jaguars vs. Lions over-under: 54 points
  • Jaguars vs. Lions money line: Jacksonville +140, Detroit -160

What you need to know about the Jaguars

One could argue that Jacksonville is overdue for a victory at home, as the Jaguars have provided enough offense to win more than once this season. Riding a four-game losing streak, it requires a distant memory to remember Jacksonville's 27-20 home win against Indianapolis in Week 1. Quarterback Gardner Minshew is ninth in the NFL with 1,439 passing yards and has thrown 10 touchdowns with just four interceptions.

Minshew's best performance of the season came in that Week 1 home victory against the Colts, as he went 19-of-20 and threw three touchdowns to compile a 142.3 passer rating. The Jaguars passing game will be helped Sunday with the absence of Detroit defensive back Desmond Trufant (hamstring), and could be bolstered even more if tight end Tyler Eifert (neck) or receiver D.J. Chark Jr. (ankle) can go. 

What you need to know about the Lions

Detroit is coming off a bye week. The Lions lost 35-29 to the New Orleans Saints two weeks ago. Matthew Stafford has thrown for two-plus TD passes in his last three road games. He has 2,435 pass yards (304.4 per game) and 10 TDs vs. two INTs in eight career starts vs. AFC South teams. After missing the first two games of the season, Kenny Golladay scored in Weeks 3 and 4. He has caught a TD pass in his last three road games. 

Adrian Peterson had his first rushing TD of the season in Week 4. He ranks fourth in NFL history in rushing TDs (112) and fifth in rushing yards (14,461). D'Andre Swift had his first career receiving TD in Week 4. He has 50-plus scrimmage yards in two of his past three games. T.J. Hockenson caught his second TD pass of the season in Week 4. 

How to make Jaguars vs. Lions picks

The model has simulated Jaguars vs. Lions 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Jaguars vs. Lions? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Lions vs. Jaguars spread to jump on Sunday, all from the model that enters Week 6 of the NFL season on an incredible 106-70 roll.