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Geno Smith and the Seattle Seahawks (1-2) travel east to take on Jared Goff and the Detroit Lions (1-2) in a NFL Week 4 matchup at Ford Field on Sunday. Both teams are looking to bounce back from tough Week 3 losses. The Seahawks fell short at home, losing 27-23 to the Atlanta Falcons, while the Lions lost 28-24 to the Minnesota Vikings. The Lions will be without their two most explosive offensive players, as running back D'Andre Swift (shoulder) and wide receiver Amon-Ra St. Brown (ankle) have both ruled out for this matchup.

Detroit is favored by 3.5 points in the latest Lions vs. Seahawks odds from Caesars Sportsbook, and the over/under is set at 47.5. Before making any Seahawks vs. Lions picks, you need to see the NFL predictions and betting advice from the red-hot simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Lions vs. Seahawks and just locked in its picks and NFL Week 4 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Lions vs. Seahawks:

  • Lions vs. Seahawks spread: Lions -3.5
  • Lions vs. Seahawks over/under: 47.5 points
  • Lions vs. Seahawks picks: See picks here
Featured Game | Detroit Lions vs. Seattle Seahawks

What you need to know about the Lions

The Lions will be extremely short-handed on the offensive side of the ball without Swift and St. Brown on Sunday. Both players are Pro Bowl talents, and their production will be difficult for Detroit to replace. Jamaal Williams has proven to be a capable NFL running back, and he will have the added benefit of running behind arguably the NFL's best offensive line.

Defensively, the Lions have been inconsistent, but they appear to have struck gold with rookie defensive end Aidan Hutchinson, the No. 2 overall pick in the 2022 NFL Draft. The former Michigan standout has three sacks, four QB hits, two tackles for loss, and seven total tackles through three games in 2022.

What you need to know about the Seahawks

Meanwhile, Seattle was within a late touchdown of stealing the win, but ultimately took a loss against the Atlanta Falcons 27-23. No one had a standout game offensively for the Seahawks, but they got scores from WR DK Metcalf and TE Will Dissly. Smith ended up with a passer rating of 145.2.

The Seahawks have had major issues defending the run in 2022, allowing 157 yards per game on the ground -- the third worst figure in the NFL. Likewise, Seattle has had some issues establishing its ground game on the offensive side of the ball, averaging a paltry 74.7 rushing yards per game (fourth worst in the league). For the Seahawks to pull off a road win over Detroit in Week 4, they will need to reverse these trends.

How to make Lions vs. Seahawks picks

The model has simulated Lions vs. Seahawks 10,000 times and the results are in. The model is leaning Under on the point total, and it also says one side of the spread hits in over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Seahawks vs. Lions? And which side of the spread hits over 50% of the time? Visit SportsLine right now to find out which side of the Lions vs. Seahawks spread you should be all over, all from the model on a 139-103 roll on its top-rated NFL picks, and find out.