The Detroit Lions came within a few plays of a miraculous comeback win in Week 1. Detroit ultimately fell short, however, losing to the San Francisco 49ers to begin their 2021 season with a record of 0-1. On Monday Night Football, the Lions will seek their first victory, but they will face a challenge with a road trip to Green Bay. Detroit takes on the Packers, with Green Bay coming off to a season-opening loss at the hands of the New Orleans Saints.

Kickoff is at 8:15 p.m. ET at Lambeau Field. Caesars Sportsbook lists the Packers as 11.5-point favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 48.5 in the latest Packers vs. Lions odds. Before you make any Lions vs. Packers picks and NFL predictions, make sure you see what SportsLine NFL expert R.J. White has to say.

CBS Sports' Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White has gone an astounding 43-13 on his last 56 picks involving Green Bay, returning more than $2,800. Anyone who has followed him is way up.

Now, White has set his sights on Lions vs. Packers. You can head to SportsLine to see his picks. Now, here are several NFL betting lines and trends for Lions vs. Packers:

  • Packers vs. Lions spread: Packers -11.5
  • Packers vs. Lions over-under: 48.5 points
  • Packers vs. Lions money line: Packers -550, Lions +400
  • DET: Lions are 4-4 against the spread in the last eight road games
  • GB: Packers are 6-4 against the spread in the last 10 home games

Why the Lions can cover

Detroit was fairly impressive offensively in Week 1, including a strong effort from new quarterback Jared Goff. He finished in the top five of the NFL in completions (38), passing yards (338) and passing touchdowns (three) last week and has a Super Bowl trip on his profile.

The Lions also have a top-flight pass-catching weapon at tight end in T.J. Hockenson. The former first-round pick caught eight passes for 97 yards and a touchdown last week. Detroit's running game wasn't dominant, but the Lions have a pair of intriguing pass-catchers out of the backfield in D'Andre Swift and Jamaal Williams. Each had eight receptions in the opener to provide Goff with safety valve options. Green Bay's defense struggled to the tune of 38 points allowed in Week 1 and, with the Packers struggling offensively in the opener, this is a very large point spread given Detroit's talent.

Why the Packers can cover

The Lions overhauled their offense in the offseason and, despite gaudy counting stats, Detroit averaged just 5.2 net yards per pass attempt in the opener. Defensively, the Lions allowed more points (41) than any other NFL team in Week 1 and gave up 442 total yards to San Francisco.

That comes on the heels of a 2020 season in which the Lions ranked dead-last in both total defense and scoring defense in the league. Detroit allowed 2.98 points and 39.8 yards per drive, both last in the NFL, and forced only 12 turnovers while allowing 38 touchdown passes. With that defensive uncertainty facing an offense keyed by Aaron Rodgers and top-flight skill players, the Packers should be able to maintain efficiency while also incorporating explosiveness.

How to make Packers vs. Lions picks

White has analyzed this matchup and while we can tell you he's leaning over the total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and who to back, at SportsLine.

So who wins Lions vs. Packers on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see White's Lions vs. Packers pick, all from the NFL expert who's 43-13 on picks involving Green Bay, and find out.