AFC West Division rivals will meet on Monday Night Football when the Las Vegas Raiders take on the Los Angeles Chargers. The Raiders (3-0), tied for first with the Denver Broncos at 3-0, will try to win their fourth road game in a row dating back to last season. The Chargers (2-1), who are third in the AFC West, were 4-4 at home last season and are 16-17 there since moving back to Los Angeles in 2017. The Raiders have won two consecutive games against the Chargers in Los Angeles.

Kickoff from SoFi Stadium in Inglewood, Calif., was set for 8:15 p.m. ET, but kickoff was moved to 8:50 p.m. ET due to lightning. Los Angeles is a three-point favorite in the latest Raiders vs. Chargers odds from Caesars Sportsbook, while the over-under for total points scored is 51.5. Before you make any Chargers vs. Raiders bets or Week 4 predictions, make sure you check out what SportsLine NFL expert Mike Tierney has to say.

A national sportswriter whose work appears in The New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. He's used his experience to crush the NFL, going 187-147 against the spread the past three seasons. In addition, Tierney is 25-13-1 on his last 39 against the spread picks involving the Chargers. Anyone who has followed him is way up.

Now, Tierney has zoned in on Raiders vs. Chargers and just released his NFL picks and predictions. You can head to SportsLine now to see Tierney's Week 4 NFL picks. Here are the Vegas NFL odds and betting lines for Raiders vs. Chargers:

  • Raiders vs. Chargers spread: Los Angeles -3 
  • Raiders vs. Chargers over-under: 51.5 points 
  • Raiders vs. Chargers money line: Las Vegas +145, Los Angeles -170 
  • LV: Raiders are 4-0 against the spread in their last four Monday games 
  • LAC: Chargers are 4-0 ATS in their last four games against AFC West opponents
Featured Game | Los Angeles Chargers vs. Las Vegas Raiders

Why the Chargers can cover

Los Angeles' secondary is among the best in the NFL and has held opponents to just five completions of 20 or more yards, third-fewest in the league. Cornerback Asante Samuel Jr. will look for his third game in a row with an interception. He leads rookies with two picks this season. He has also registered nine tackles, including six solo, with one tackle for loss and four pass breakups.

Cornerback Tevaughn Campbell had two pass breakups and two forced fumbles in Week 3. For the season, Campbell has five tackles, including three solo. Safety Alohi Gilman, who registered his first career interception last week, has 16 tackles, including 11 solo, with one pass breakup in 2021. Gilman had a season-high seven tackles, all solo, in last week's win over the Chiefs.

Why the Raiders can cover 

Las Vegas has a potent trio at running back with Peyton Barber, Josh Jacobs (questionable, ankle) and Kenyan Drake. Barber led the team with 142 yards from scrimmage, including a career-high 111 rushing yards and a touchdown, in last week's win over Miami. For the season, he has carried 36 times for 143 yards (4.0 average) and one touchdown. He has converted nine first downs. In 81 career games spanning parts of six seasons, he has carried 681 times for 2,388 yards (3.5 average) and 20 touchdowns.

In his last game against the Chargers, Jacobs rushed for 76 yards and a touchdown and had 114 yards from scrimmage. He has two rushing touchdowns in three career games on Monday Night Football. Drake is looking for his sixth consecutive game with 50 or more yards from scrimmage. He has had 150 or more yards from scrimmage in two of his past three games on Monday night.

How to make Raiders vs. Chargers picks

For Monday Night Football, Tierney is leaning over on the point total, but he also says a critical X-factor makes one side of the spread a must-back. He's sharing his Raiders vs. Chargers picks only at SportsLine.

So who wins Chargers vs. Raiders on Monday Night Football? And what critical X-factor makes one side of the Raiders vs. Chargers spread a must-back? Visit SportsLine now to see which side of the Chargers vs. Raiders spread you need to jump on Monday night, all from the expert who's 25-13 on Chargers picks, and find out.