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Week 10 of the 2021 NFL schedule culminates with a Monday Night Football game between the Los Angeles Rams and San Francisco 49ers at Levi's Stadium. The Rams (7-2) are looking to join Arizona and Green Bay (8-2) atop the NFC with a win and are coming off a loss to Tennessee. Meanwhile, the 49ers (3-5) have lost five of their last six games and are just a half-game ahead of last place Seattle in the NFC West. San Francisco has lost eight straight games, including three that were played in Glendale, Ariz., last year due to COVID-19 restrictions.

Kickoff is set for 8:15 p.m. ET. Los Angeles is a 3.5-point favorite in the latest Rams vs. 49ers odds from Caesars Sportsbook, while the Over-Under for total points scored is 50.5. Before you make any 49ers vs. Rams picks of your own, you need to see what NFL expert R.J. White has to say.

White, a CBS Sports fantasy and gambling editor, ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White is an amazing 37-19-1 on his last 57 against-the-spread picks involving the Rams, returning $1,576 to $100 players. Anyone who has followed him is way up.

Now, he has locked in on Rams vs. 49ers and released a confident against-the-spread pick. Go here to see it. Here are the NFL lines and trends for 49ers vs. Rams:

  • Rams vs. 49ers spread: Los Angeles -3.5
  • Rams vs. 49ers Over-Under: 50.5 points
  • Rams vs. 49ers money line: Los Angeles -190, San Francisco +160
  • LAR: QB Matthew Stafford leads the league in passing yards (2,771)
  • SF: WR Deebo Samuel ranks second in the NFL in receiving yards (882)

Why the Rams can cover

Los Angeles has a significant edge in turnovers entering the game. The Rams are tied for sixth in the NFL in turnover margin, having forced 14 takeaways while turning the ball over just five times themselves. The 49ers have committed 14 turnovers while forcing just five, and their minus-nine turnover margin is the third worst in the league. Only the Jaguars and Jets are worse.

In addition, quarterback Matthew Stafford has been stellar in his first season in L.A. The former Detroit quarterback leads the NFL in passer rating (111.0) and ranks third in passing yards per game (307.9) and passing touchdowns (23). His 68.2 completion percentage is the best of his career.

Why the 49ers can cover

San Francisco has dominated the series against the Rams recently. The 49ers have won the past four meetings between the teams and the past two in Santa Clara. San Francisco's average margin of victory in those games is 6.8 points.

In addition, the 49ers face Rams quarterback Matthew Stafford, who is coming off his worst game of the season. In the Sunday night loss to the Titans, Stafford was sacked a season-high five times. He also had his first multi-interception game of the season and averaged 6.1 yards per attempt, his fewest in a game this season.

How to make Rams vs. 49ers picks

White has analyzed this matchup and while we can tell you he's leaning Under the total, he has discovered a crucial x-factor that makes one side of the spread a must-back. He's sharing it only at SportsLine.

Who wins 49ers vs. Rams on Monday Night Football? And what critical factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the 49ers vs. Rams spread you should jump on, all from the top NFL expert who is 37-19 on against-the-spread picks involving the Rams, and find out.