NFL DFS for 49ers vs. Seahawks: Best DraftKings, FanDuel daily Fantasy football picks, lineups for Week 10

The Week 10 NFL schedule concludes with Monday Night Football featuring the undefeated San Francisco 49ers (8-0) and the Seattle Seahawks (6-2) in an 8:15 p.m. ET kickoff from Levi's Stadium. NFL DFS players will have plenty of tough decisions to make. Russell Wilson has been the top-scoring Fantasy quarterback this season, but now faces a stiff challenge against a top-ranked Niners defense that gives up just 12.8 points and 241 yards per game. Should he still be part of your NFL DFS strategy for Monday Night Football? Before setting your NFL DFS strategy for tournaments like the $1.2M Monday Night Showdown on DraftKings and the $800K NFL Monday Night Special on FanDuel, be sure to see the latest NFL DFS advice from SportsLine's Mike McClure. He's a daily Fantasy pro who has won almost $2 million in his career, and his top Monday Night Football DFS picks for 49ers vs. Seahawks can help you make all the right calls for this single-game slate. 

McClure is also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account. This allows him to find the best NFL DFS values and create optimal lineups that he shares only over at SportsLine. They're a must-see for any NFL DFS player.

McClure had some eye-popping results during the 2018 NFL season, cashing in the top 5 percent of tournaments on FanDuel and DraftKings multiple times. His optimal lineups cashed as high as the top 0.1 percent on FanDuel and as high as the top 1 percent on DraftKings.

He's rolling through 2019 as well, including a strong 3x return on DraftKings in the Week 3 main slate. On Sunday of Week 5, his optimal lineup finished in the top 1 percent of tournaments on DraftKings, with his four core players -- Deshaun Watson, Michael Thomas, Christian McCaffrey and Will Fuller -- combining for a whopping 196.34 points, enough to cash in tournaments by themselves. He followed that up by cashing his FanDuel and DraftKings lineups on Sunday Night Football and Monday Night Football in Week 6 and then cashed everywhere on his SNF lineups yet again in Week 7. He continued his roll with wins on both sites on the main slate, SNF and MNF in Week 8, and then followed that up with huge 5x returns on his optimal lineups on both sites in Week 9. Anyone who has been following him has seen huge returns.

Now, he has turned his attention to 49ers vs. Seahawks on Monday Night Football and locked in his top daily Fantasy football picks over at SportsLine. 

For Monday's 49ers vs. Seahawks DFS slate, we can tell you McClure is banking on San Francisco quarterback Jimmy Garoppolo. The sixth-year pro out of Eastern Illinois has thrown for 1,806 yards and 13 touchdowns this season and is coming off a slate-breaking performance against the Cardinals in which he threw for 317 yards and four touchdowns. With a completion percentage of 75.7, no interceptions and just one sack taken, it was perhaps the most complete performance of his career. 

Now, Garoppolo gets a juicy matchup against a Seattle defense that ranks 29th in the league in passing defense (278.1 yards per game). The Seahawks have already conceded head-turning days to quarterbacks like Andy Dalton (418-2), Jared Goff (395-1) and Matt Schaub (460-1) this season, so confidently lock in Garoppolo as one of your top NFL DFS picks for Monday Night Football. 

Part of his optimal Seahawks vs. 49ers DFS strategy also includes rostering Seattle running back Chris Carson. He's seen one of the heaviest workloads in the NFL recently, taking at least 20 touches in five of his last six games. On the season, he's now rushed 175 times for 764 yards and three touchdowns, while adding 177 yards and two scores as a receiver. 

Carson draws a tough matchup against the Niners, one of the league's best defenses. But if San Francisco has a weakness on that side of the ball, it's against the run, because the 49ers are allowing over 100 yards per game on the ground. McClure's model projects enough work for Carson, who has gone off for at least 3x on DraftKings four times this season, to return plenty of value.

McClure is also targeting a player who could go off for massive numbers on Monday Night Football because of a dream matchup. This pick could be the difference between winning your tournaments and cash games or going home with nothing.

So who is DFS pro Mike McClure putting in his optimal NFL DFS lineup on Monday night? Visit SportsLine now to see the full optimal tournament lineups for 49ers vs. Seahawks from a professional DFS player who has almost $2 million in career winnings, and find out.

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