Nine games kick off at 1 p.m. ET on Sunday as part of the Week 8 NFL schedule, including the Rams playing the winless Bengals in London and the surprising Bills hosting the underachieving Eagles in an intriguing inter-conference matchup. In the compelling late afternoon slate, the undefeated 49ers host the surging Panthers. Should San Francisco or Carolina be among your top NFL confidence picks for Week 8? Favorites went 11-3 straight-up last week, beginning to re-establish themselves after NFL underdogs thrived for the first six weeks. That lends hope to Buffalo backers, as the Bills are laying 1.5 points. But will the Eagles, a trendy preseason Super Bowl pick, drop a third straight game? And which team should you back with your NFL office pool picks? Before you make your NFL predictions, look at the Week 8 NFL picks from the proven computer model at SportsLine. 

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on its top-rated NFL picks since its inception four years ago. It has nailed its recent top-rated NFL picks, entering Week 8 of the 2019 NFL schedule on a strong 24-17 run that dates back to last season. It's also on an incredible 86-60 roll on top-rated NFL picks that dates back to the 2017 season. And in Week 7, it nailed the Chiefs (-3) covering with plenty of room to spare against the Broncos and the Ravens (+3) covering against the Seahawks in a game Baltimore won outright by 14.

The model also ranked in the Top 10 on NFLPickWatch for the third year in a row on straight-up NFL picks and beat more than 96 percent of CBS Sports office pool players. It went a sparkling 10-4 last week. Anyone who has followed it is way up.

Now, the model has simulated the entire slate of Week 8 NFL games 10,000 times and generated its optimal NFL pick'em plays. We can tell you the model likes the 5-1 Bills, who are winning 57 percent of simulations against the visiting Eagles. 

Buffalo ranks third in total defense (292.7 yards) and points allowed per game (15.2). The Bills have not allowed any opponent to score more than 21 points this season.

The Bills' only loss came to the mighty Patriots, and Buffalo had a chance to win that game late before falling 16-10. Philly, meanwhile, is playing its third straight road game and struggling to find enough healthy defensive linemen. Lock in the Bills as one of your top NFL pool picks in Week 8. 

The model also has made the call on 49ers vs. Panthers, Packers vs. Chiefs, Buccaneers vs. Titans and the rest of the Week 8 NFL schedule. In fact, the model says one team the public loves goes down in flames. You can only see all of the model's NFL pool picks at SportsLine. 

So who should you pick in every Week 8 NFL game? And which public darling gets stunned? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that beat over 96 percent of CBS Sports office pool players last year.