We're only five weeks into the 2022 NFL schedule, but the Philadelphia Eagles have been the only safe bet for two weeks in NFL office pool picks. The Eagles are 5-0 heading into a matchup with the 4-1 Cowboys on Sunday Night Football and will have the benefit of taking on backup quarterback Cooper Rush with Dak Prescott (thumb) beginning his throwing program after surgery. However, Rush is 4-0 as a starter and Dallas' defense looks like one of the best in the NFL with Micah Parsons leading the way.
The Eagles are 6.5-point favorites in the Week 6 NFL odds from Caesars Sportsbook and might be a compelling selection as you make your Week 6 NFL confidence pool picks. Before you make your Week 6 NFL pick'em predictions, you need to see the Week 6 NFL football pool picks from SportsLine's proven model.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.
More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated the entire Week 6 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them now.
Top Week 6 NFL office pool predictions
One of the top Week 6 NFL predictions from the model: The San Francisco 49ers earn a comfortable nine-point win on the road against the Atlanta Falcons. Mike Tomlin's 16th season at the helm of the Steelers is looking like it could be his first with a losing record with Pittsburgh off to a 1-4 start. Ben Roethlisberger retired during the offseason and now the franchise has turned to first-round pick Kenny Pickett after a failed month with Mitchell Trubisky as the starter.
However, Pickett and the Steelers were blown out 38-3 by the Bills in his first career start last week and Tomlin's squad ranks 27th in DVOA through five weeks with four consecutive losses under their belt. Pittsburgh has turned the ball over nine times during that losing streak and the Buccaneers rank fifth in the NFL with nine takeaways through their first five games.
Tom Brady has thrown for 736 yards and four touchdowns without an interception in his last two games and the model is predicting that reaches the 300-yard mark yet again on Sunday. That helps the Buccaneers win outright in nearly 70 percent of simulations and makes them one of the model's safest Week 6 NFL pool picks. See the rest of the model's Week 6 NFL pool picks here.
How to make Week 6 NFL office pool picks
The model also made the call on every other Week 6 NFL game and has strong picks for potentially close matchups like Bills vs. Chiefs and Seahawks vs. Cardinals. It's also calling for several big favorites to struggle more than expected and several surprising teams to hang tough. You can only see all of the model's NFL pool picks here.
So who should you pick in every Week 6 NFL game? And which underdogs should you back? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the top 10 on straight-up picks four of the last six years and went an outstanding 146-106 on top-ranked picks against the spread since 2017.
