The Jacksonville Jaguars are 0-2 in Urban Meyer's first season with the team, and their Week 3 matchup doesn't look promising. The Jaguars are 7.5-point underdogs in the latest NFL odds from Caesars Sportsbook against the Arizona Cardinals, a team that has lit up scoreboards in its first two games of the season. The Jaguars are a hot candidate for the "just pick whoever's playing this team" strategy in NFL confidence pool picks, and for good reason.

Bettors and SportsLine's proven model both like the Cardinals' chances this weekend. Even with top quarterback prospect Trevor Lawrence, the Jags have a tough road ahead. The Cardinals, meanwhile, seem to be hitting their stride with quarterback Kyler Murray, who is second in total passing yards and passing touchdowns in the young season. Should you select the Cardinals in your NFL office pool picks? Before you make your NFL predictions, you need to see the Week 3 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 122-81 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 3 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them.

Top Week 3 NFL office pool predictions

One of the top Week 3 NFL pick'em predictions from the model: Las Vegas cruises past Miami and gets a comfortable win at home as a four-point favorite.

The Raiders are 2-0 after wins over the Ravens and Steelers, while the Dolphins are 1-1 after beating the Patriots and getting steamrolled by the Bills. Miami won't have quarterback Tua Tagovailoa as he recovers from an injury, while Derek Carr has been piling up stats for the Raiders.

Carr is the NFL's leader in total passing yardage by over 100 yards in 2021. The Raiders are favored to win this one at home for a reason. SportsLine's simulations have the Raiders covering 50 percent of the time, while you should also back the over.

How to make Week 3 NFL office pool picks

The model also made the call on every other Week 3 game and has strong picks for potentially close matchups like Rams vs. Buccaneers and Seahawks vs. Vikings. It's also calling for a Super Bowl contender to go down hard. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 3 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 122-81 on top-ranked picks since 2017 .