The 2021 NFL schedule started with eight underdogs winning outright in Week 1. NFL pick'em players who took chances and hit those NFL picks likely moved toward the top of their pool's standings. The Week 2 NFL odds could offer a chance to hone your NFL office pool picks, but overcorrecting too much or being too discrediting of Week 1 results could lead to problems. Which NFL office pool picks should you make?

The Bills underperformed coming off their 13-3 season with a loss to the Steelers, while the Dolphins won as underdogs in New England. Now, the two AFC East rivals will go head-to-head in a surprisingly important Week 2 divisional matchup, but after what we saw last week, should you play a correction or ride the hot hand with your Week 2 NFL confidence pool picks? Before you make your NFL predictions, you need to see the Week 2 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 2 2021 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them.

Top Week 2 NFL office pool predictions

One of the top Week 2 NFL pick'em predictions from the model: Arizona cruises past Minnesota and gets a comfortable win at home as a 4.5-point favorite.

It has been two years of slow but steady progress with Kliff Kingsbury guiding former No. 1 overall pick Kyler Murray, but after dismantling an 11-win team in Week 1 fans are hopeful the Cardinals are among the league's top contenders.

Murray used his incredible mobility to extend plays in a 38-13 win over the Titans last week, completing 21 of 32 passes for 289 yards and four touchdowns while adding 20 rushing yards and another score on the ground. Wide receiver DeAndre Hopkins was the human-highlight reel they traded for him to be, making an incredible catch in the back of the end zone for his first score and turning a defender inside out by sticking his foot in the ground and changing direction after catching a slant for his second.

The model predicts that Murray piles up over 300 yards of total offense and three touchdowns on average, while Hopkins catches eight passes for just under 100 yards and a touchdown. That's helps the Cardinals win in well over 60 percent of simulations and cover in nearly 60 percent of projections as well.

How to make Week 2 NFL office pool picks

The model also made the call on every other Week 2 game and has strong picks for potentially close matchups like Chiefs vs. Ravens and Rams vs. Colts. It's also calling for a Super Bowl contender to go down hard. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 2 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 121-79 on top-ranked picks since 2017 .