Arizona has been the best team to back in NFL pick'em pools this season, winning all six of its games. The Cardinals are coming off a 37-14 blowout win at Cleveland last week despite entering the game as three-point underdogs. They are the largest favorite on the board in Week 7, laying 18.5 points to Houston in the latest NFL odds at Caesars Sportsbook. Arizona could be one of your NFL office pool picks this week, but should they also be among your top NFL confidence pool picks?

The Cardinals will have competition from the Rams (-16) and Buccaneers (-11.5) for one of the top NFL knockout pool picks. The only way to know you are making the right decision is to look at Week 7 NFL predictions from a proven source. Before you make your NFL predictions, you need to see the Week 7 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 7 of the 2021 season on an incredible 125-85 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 7 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them.

Top Week 7 NFL office pool predictions

One of the top Week 7 NFL pick'em predictions from the model: The Raiders cruise past the Eagles for a comfortable seven-point win. Philadelphia's hopes of competing for the NFC East crown are slipping away following a fourth loss in five games. The Eagles have been unable to compete with strong offenses, coming up short against Dallas, Kansas City and Tampa Bay. They will now be without tight end Zach Ertz after he was traded to Arizona last week.

Las Vegas snapped a two-game losing streak with its win at Denver in Week 6. The Raiders have put the Jon Gruden situation behind them and are prepared to compete for the AFC West crown. Quarterback Derek Carr has completed 64.2 percent of his passes for 1,946 yards and 10 touchdowns.

SportsLine's model is projecting Carr to throw for 293 yards and two touchdowns against Philadelphia on Sunday. The Raiders are winning in over 60 percent of simulations and covering the spread more than 50 percent of the time. 

How to make Week 7 NFL office pool picks

The model also made the call on every other Week 7 game and has strong picks for potentially close matchups like Chiefs vs. Titans and 49ers vs. Colts. It's also calling for an underdog to win outright. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 7 NFL game? And which underdog wins outright? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 125-85 on top-ranked picks since 2017.