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The Cardinals and the Rams will meet on Sunday in a matchup of two undefeated teams that have been top choices in NFL confidence pool picks. Both teams are 3-0, but barring the unlikely event of a tie, only one will finish the week undefeated. The Rams are 4.5-point favorites at home, according to the Week 4 NFL odds at Caesars Sportsbook. Who should you target in your NFL office pool picks?

Should you select one of them in your NFL pick'em pool, or should you go with a team that's a bigger favorite? In the Week 4 NFL spreads at Caesars, the Bills are -16 against the Texans, the Bengals are -7.5 against the Jaguars and the Buccaneers are -7 against the Patriots. Before you make your NFL predictions, you need to see the Week 4 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 123-81 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 4 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them.

Top Week 4 NFL office pool predictions

One of the top Week 4 NFL pick'em predictions from the model: Tennessee cruises past the New York Jets and gets a comfortable win as a six-point favorite.

Tennessee is 2-1 on the season, with its only loss coming to the undefeated Cardinals. After running back Derrick Henry and the rest of the Titans' offense failed to get going in Week 1, they've produced at a steady rate since.

After the Cardinals bottled him up for 58 yards in Week 1, Henry has rushed for 182 and 113 yards his last two times out. The Jets have yet to allow an opposing team to rush for under 100 yards this season. That's why SportsLine's projections have Henry rushing for at least 100 yards for the third straight game. SportsLine's simulations see the Titans winning 60 percent of the time. The point total, which sits at 44, goes under in well over 50 percent of simulations.

How to make Week 4 NFL office pool picks

The model also made the call on every other Week 4 game and has strong picks for potentially close matchups like Broncos vs. Ravens and 49ers vs. Seahawks. It's also calling for a Super Bowl contender to go down hard. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 4 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 123-81 on top-ranked picks since 2017 .