Tom Brady's return home to New England was a success for the quarterback, his team and anyone who backed the Buccaneers in their NFL office pool picks. Brady and the Bucs should have an easier time in Week 5 as big favorites against the Dolphins. Tampa Bay is favored by 10 points in Miami, according to the NFL odds at Caesars Sportsbook. They'll find an opponent starting a backup quarterback with losses in its three games since defeating the Patriots in Week 1.

Should you select the Buccaneers in your NFL pick'em pool? What about in your NFL confidence pool picks? Before you make your NFL predictions, you need to see the Week 5 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 5 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them.

Top Week 5 NFL office pool predictions

One of the top Week 5 NFL pick'em predictions from the model: The Cowboys cruise past the Giants for a comfortable nine-point win. The Cowboys played close games against the two of the NFL's best teams in the Buccaneers and Chargers, losing the first and winning the second, then won by double-digits against the Eagles and Panthers. Their passing attack with Dak Prescott throwing to Amari Cooper, CeeDee Lamb and Dalton Schultz has been one of the league's best, helping the Cowboys rank fourth in offensive efficiency.

SportsLine's model sees this game as a 31-23 Cowboys win, with Dallas winning and covering the spread in more than 50 percent of simulations. The model projects Prescott to have almost 300 yards passing and at least two touchdowns, with Cooper, Lamb and Schultz combining for nearly 200 yards.

How to make Week 5 NFL office pool picks

The model also made the call on every other Week 5 game and has strong picks for potentially close matchups like Bills vs. Chiefs and Packers vs. Bengals. It's also calling for multiple underdogs to win outright. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 5 NFL game? And which underdogs win outright? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 124-82 on top-ranked picks since 2017 .