We'll see more backup quarterbacks on the field in Week 6 as Lamar Jackson of the Ravens and Brock Purdy of the 49ers were both ruled out on Friday. That means backup Cooper Rush will start vs. the Rams for Baltimore while Mac Jones gets another shot for San Francisco.
Another quarterback who showed up on the injury report Wednesday was Kyler Murray of the Cardinals. He is nursing a foot injury and did not participate in Wednesday or Thursday. He was back on the practice field on Friday and listed as questionable for Sunday's game vs. the Colts. Jacoby Brissett will be the starter if Murray is unable to go.
Injuries are piling up at running back, too. Omarion Hampton (ankle) will miss at least the next four games after the Chargers placed him on injured reserve. He joins the likes of James Conner, Trey Benson, Chuba Hubbard, Jaylen Warren, Bucky Irving and Hampton's own teammate Najee Harris as notable ball carriers dealing with injuries.
Other notable injuries around the league include Steelers cornerback Jalen Ramsey (hamstring), Buffalo Bills linebacker Matt Milano (pectoral), Detroit Lions cornerback Terrion Arnold (shoulder), Dallas Cowboys linebacker Jack Sanborn (concussion), New England Patriots running back Antonio Gibson (knee) and New Orleans Saints safety Justin Reid (concussion).
A late addition to the Patriots' injury report for the Week 6 game agains the Saints. Defensive tackle Milton Williams is now questionable because of an illness. Williams has started all five games this year and has 2.5 sacks. Remember: CB Christian Gonzalez is also questionable leading into the 1 p.m. kickoff.
Jayden Daniels will once again be without his top receiver when the Commanders face the Bears on Monday Night Football. Washington ruled Terry McLaurin (quad) out for Monday's game, along with fellow receiver Noah Brown (groin), as both are nursing leg injuries that have kept them out for the past few weeks.
Deebo Samuel has been the workhorse for the Commanders of late, leading the team with 30 catches for 300 yards and 3 TDs in an otherwise thin receiving corps. Veteran tight end Zach Ertz has also been a frequent target, but without McLaurin and Brown, the Commanders passing game is lacking the kind of explosiveness they were known for last year.
Pittsburgh Steelers defensive back Jalen Ramsey has been upgraded from questionable and is expected to play against the Cleveland Browns on Sunday. Ramsey suffered the injury in Week 4 against the Minnesota Vikings in Dublin, Ireland. The veteran and three-time first team All-Pro has lined up in multiple spots in the Steelers secondary this season, totaling eight tackles, an interception and four passes defensed.
Dallas Cowboys running back Miles Sanders will miss the remainder of the season due to injury, Cowboys executive vice president Stephen Jones said Friday on 105.3 The Fan. The team will move Sanders to the season-ending injured reserve as he deals with knee and ankle issues. According to ESPN's Todd Archer, it is the knee ailment that will keep Sanders on the shelf for the rest of the year as he is set to undergo a chondral tissue graft surgery.
While Sanders' injury is a blow to the Cowboys' running back group, it does also provide an opportunity for rookie ballcarrier Jaydon Blue, who made his NFL debut last week in Sanders' absence. The Texas product and fifth-round pick handled four carries for seven yards but could see a larger role in the weeks to come.
49ers quarterback Brock Purdy (toe) is officially out for San Francisco's Week 6 game against the Buccaneers. Backup quarterback Mac Jones is listed as questionable (oblique/knee), but CBS Sports senior reporter Matt Zenitz says he will get the start on Sunday.
Purdy's toe injury was initially sustained in their Week 1 win against the Seahawks and aggravated in their Week 4 loss against the Jaguars. Jones is 3-0 as a starter and leads the league with an average of 301.7 passing yards per game this season.
The Niners and Bucs both enter the game 4-1.
The Ravens will be without star quarterback Lamar Jackson for a second street week as he nurses a hamstring injury, but tackle Ronnie Stanley, safety Kyle Hamilton and cornerback Marlon Humphrey were all off the injury report Friday and will play Sunday against the Rams.
At 1-4, Baltimore is off to its worst start since 2015. Injuries have played a big role in the rough beginning to the season. Here's the team's full injury report for Sunday:
Las Vegas Raiders star tight end Brock Bowers will likely miss his second consecutive game because of a knee injury, coach Pete Carroll confirmed on Friday. Bowers didn't play in Las Vegas' blowout loss to the Colts last weekend because of the injury. In four games this season, Bowers has caught 19 passes for 255 yards. He began the 2025 season right where he left off by catching five passes for 103 yards during a 20-13 win over the Patriots.
Christian Gonzalez was a limited participant at Patriots practice for the second day in a row and is now questionable to play against the Saints. The team indicated that this is part of managing the hamstring issue that held him out for the first three weeks of the season. Gonzalez, according to the staff, is on a training room plan that eases him into practice.
"It's kind of a warm-up, the early portion of practice," cornerbacks coach Justin Hamilton said. "Just to do more because some of the stuff is special teams or different things where it's a jog-through, walk-through. It's for him to just be able to get to the pace that he can go at to be able to get out there when we are in the speed periods of practice."
Gonzalez is an All-Pro cornerback and one of the top players on the Patriots roster. He returned from a three-week absence to play in each of the last two games.
Will it be another big week for Panthers running back Rico Dowdle? With Chuba Hubbard ruled out once again, Dowdle is in line for the bulk of the carries for Carolina as the Cowboys -- Dowdle's former team -- visit Charlotte. Dowdle exploded for a career-high 206 yards on 23 carries in last week's win over the Dolphins and he could be in for a similar workload against Dallas.
Bengals wide receiver Ja'Marr Chase will be listed as questionable for Sunday's game against the Packers, coach Zac Taylor said on Friday. Taylor said Chase missed Friday's practice with an illness. He is listed as "not injury related/rest" on the injury report.
Chase was limited in practice on Wednesday and was a full participant on Thursday.
After missing Wednesday and Thursday's practice with a foot injury, Cardinals quarterback Kyler Murray will return to practice on Friday, coach Jonathan Gannon said. Gannon added Murray's status for Sunday's game against the Colts will be dependent on how the next few days go.
His foot injury was sustained in the second half of Arizona's Week 5 loss against the Titans.
If Murray is sidelined, veteran Jacoby Brissett is expected to get the start.
Ravens quarterback Lamar Jackson missed practice on Friday as he continues to deal to a hamstring injury. The missed practice means Cooper Rush will get the start against the Rams, per CBS Sports lead NFL insider Jonathan Jones.
The Ravens have a bye week for Week 7, which means Jackson will have some extra time for recovery.
Jackson missed last week's game against the Texans due to the injury.
The Buccaneers offense will likely be without one of their weapons when they face the 49ers on Sunday. Wide receiver Chris Godwin is not expected to play as he deals with a fibula injury, according to ESPN. Godwin did not practice on Wednesday or Thursday this week, leading up to the Week 6 home game.
Godwin has 52 yards on 14 receptions in two games played this season, coming in Week 4 and Week 5.
Standout cornerback Christian Gonzalez missed the Patriots' first three games with a hamstring issue but was a full go in Weeks 4 and 5 when he contributed to back-to-back wins. The reigning All-Pro defender is back on the injury report, however, ahead of Sunday's matchup against the Saints. It's a hamstring issue for Gonzalez again, and it made him a limited participant in practice on Thursday. That is especially notable because he participated in full for Wednesday's practice.
Gonzalez, a former first-round pick, has three career interceptions and broke up 11 passes last year in a breakout campaign.
Dean was officially activated from the Eagles' reserve/physically unable to perform list on Thursday afternoon. He is expected to make his season debut tonight against the New York Giants, according to CBS Sports senior reporter Matt Zenitz. The Philadelphia Eagles linebacker sustained a serious knee injury during Philadelphia's 2024 playoff run but was a full participant in practices both Tuesday and Wednesday.
Quarterbacks Lamar Jackson and Kyler Murray did not practice for their respective teams on Thursday. Jackson is dealing with a hamstring issue that sidelined him during Baltimore's Week 5 loss to the Texans. Murray has been hampered by a foot injury that was sustained during the second half of Arizona's Week 5 loss against the Titans.
If Murray can't go, the Cardinals have a veteran quarterback ready to go in Jacoby Brissett. A 10-year veteran, Brissett has played in 89 regular season games with 53 starts. He has a 19-34 record as an NFL starter.
If Jackson can't go for Baltimore, the Ravens will likely again turn to veteran Cooper Rush, who threw three picks during last week's blowout loss vs. Houston. The Ravens, could, however, turn to Tyler Huntley, who has extensive experience running Baltimore's offense. A former Pro Bowler, Huntley has made 10 starts for Baltimore that includes one playoff game back in 2022.
The Green Bay Packers have serious concerns over Brandon McManus' health. The Packers are preparing a contingency plan after the kicker injured his right quadracep this week.
McManus was listed as a limited participant for Wednesday's practice, and the team is unsure if he'll make it to Sunday's game against the Cincinnati Bengals.
"That's a major concern right now," coach Matt LaFleur told reporters at Thursday's press conference. "We'll see how he's doing today and tomorrow. We'll have a plan ready to go."
Initially, it was believed McManus suffered the injury while making a tackle in Dallas. LaFleur, however, stated the injury happened during Wednesday's practice. Should McManus' condition prevent him from playing this weekend, rookie Mark McNamee is on the practice squad as a second kicker. LaFleur did not confirm that McNamee, who has never kicked in a regular-season NFL game, would replace McManus.
"It's never the situation you want to be, in regards to the first time you go out there," LaFleur said. "But Mark has shown some good progress."
Raiders star tight end Brock Bowers (knee) didn't practice on Wednesday. Bowers didn't play in Las Vegas' blowout loss to the Colts last weekend because of the injury. In four games this season, Bowers has caught 19 passes for 255 yards. He began the 2025 season right where he left off by catching five passes for 103 yards during a 20-13 win over the Patriots.
Las Vegas hosts the Tennessee Titans on Sunday.
The Eagles will be without guard Landon Dickerson and tight end Grant Calcaterra for their "Thursday Night Football" matchup against the New York Giants. Both were injured in the loss to the Broncos on Sunday. Dickerson entered the season with a knee injury and is now dealing with an ankle injury. Calcaterra, the team's No. 2 tight end, has an oblique injury. Saquon Barkley (knee) was a full participant and will play.
On the defense, star defensive tackle Jalen Carter popped up on Wednesday's injury report as a limited participant and is currently considered questionable to play Thursday. Nakobe Dean is also listed as questionable but is expected to make his season debut, according to CBS Sports' Matt Zenitz. Dean, a starter at linebacker, injured his knee during last year's run to the Super Bowl and may not be ready for a full workload on Thursday, but he'll be involved.
On the heels of a game in Ireland and an off week, the Steelers are getting healthier with standouts like running back Jaylen Warren and cornerback Joey Porter Jr. trending toward a return to the field, per Mike Tomlin.
The Cardinals are still licking their wounds from the embarrassing 22-21 loss to the Tennessee Titans on Sunday, and coach Jonathan Gannon confirmed they won't have QB Kyler Murray at practice due to a foot injury.
Murray missed a few plays of the Titans game after diving on a loose ball following an errant snap. He visited the injury tent but was able to finish out the game. He completed 23 of 31 passes for 220 yards (T-season high), and had 25 rushing yards with a rushing TD vs. the Titans.
If Murray cannot play, the Cardinals will turn to veteran backup Jacoby Brissett for Sunday's road game against the 4-1 Indianapolis Colts. The Cardinals are looking to snap a three-game losing streak after opening the season with two wins. Those three losses have come by a combined five points.
Heading into a key matchup with the Tampa Bay Buccaneers this weekend, the San Francisco 49ers could be without several key players on offense once again. Quarterback Brock Purdy (toe) and receivers Ricky Pearsall and Jauan Jennings (ribs/ankle) won't practice on Wednesday. 49ers coach Kyle Shanahan told reporters that the team isn't "counting on" Pearsall being available for Week 6 vs. Tampa. Pearsall exited Week 4 vs. the Jacksonville Jaguars with the knee injury and did not return to the game.
Pearsall, Jennings and Purdy all didn't play during a Week 5 26-23 overtime win over the Los Angeles Rams.
If Purdy doesn't play this week, Mac Jones will be in line to make his fourth start with the 49ers. Jones was limited in practice due to a knee injury.
Ravens quarterback Lamar Jackson is once again not participating in practice due to a hamstring injury he suffered in Week 4 against the Chiefs. Wednesday marks the fourth straight practice he has missed with the injury.
His no practice status is not good news for their Week 6 game against the Rams and his official injury designation will come later this week.
Jackson was sidelined for Baltimore's Week 5 41-10 loss against the Texans. It was his first missed game due to injury since 2022. According to reports, he could miss two to three weeks total with the strained hamstring.
If Jackson misses another game, expect Cooper Rush to be the starter for a second straight week.
The New York Giants released their injury report ahead of their Thursday Night Football matchup with the Eagles, and there is a bit of good and bad news when it comes to the availability of key offensive players. The good news is they will have their backfield at full strength, as Tyrone Tracy Jr. is not listed on the injury report after missing the last two games with a shoulder injury and will be a full go alongside Cam Skattebo. Tracy has accounted for 122 combined rushing and receiving yards in his three appearances this season, and will be back in the lineup to give New York some added juice in the backfield.
The bad news is the wide receiving corps took another hit as Darius Slayton is officially listed as OUT this week due to a hamstring injury. With Malik Nabers already out after suffering a season-ending knee injury in Week 4, Jaxson Dart will have to go up against the defending champs without two of the team's top three receivers. With Slayton out, Wan'Dale Robinson, Jalin Hyatt and Beaux Collins will be Dart's top three options on the outside this week.
Detroit Lions cornerback Terrion Arnold looks like he will be coming back a lot sooner than expected. Arnold, who is dealing with a shoulder injury, was first feared to be out for a significant amount of time, but a second opinion revealed positive news for the 2024 first-round pick.
The second opinion revealed the injury is "not as bad as feared," according to ESPN, and he is expected to return "sooner than expected," possibly this month. He is still expected to miss some time, but an October return is significantly better for Dan Campbell's defense than they first thought.
That's especially good news for Detroit, which had recently placed DJ Reed (hamstring) on IR and did the same with Khalil Dorsey on Wednesday.
Broncos left guard Ben Powers tore his biceps on the final drive of the Broncos' Week 5 win against the Eagles according to ESPN's Jeff Legwold, and will significant time after undergoing surgery. He did not travel with the team to London for its Week 6 game against the Jets and is reportedly headed to IR.
The Broncos' unofficial depth chart lists Alex Palczewski as the backup left guard, though coach Sean Payton declined to name Powers' replacement. Powers, 28, is Pro Football Focus' 19th-ranked guard out of 64 who have played at least 150 snaps this season. He had not missed a single game with Denver since arriving from Baltimore ahead of the 2023 season.
The Colts announced Wednesday that they placed Joe Bachie on IR with an undisclosed injury. He will miss at least four weeks. Indianapolis signed Germaine Pratt, who was recently released by the Raiders, in a corresponding move.
Bachie has started all five of Indianapolis' games this season, and is a key member of the Colts' special teams units as well. He has 26 total tackles this season, fourth on the team. Austin Ajiake and, eventually, Pratt will likely take the lion's share of the defensive reps Bachie vacates.
The Jacksonville Jaguars are placing tight end Brenton Strange on injured reserve, meaning he will be out for at least the next four weeks. Strange exited "Monday Night Football" in the second quarter during his team's eventual 31-28 win over the Kansas City Chiefs with a hip injury and did not return.
NFL Media's Mike Garafolo reported that Strange is expected to miss about a month with the quad injury, which means he will be able to return at some point during the 2025 season.
Strange caught one pass for 22 yards in the first quarter against Kansas City and is viewed as one of the best run-blocking tight ends in the NFL. He was seen on Jacksonville's sideline during the game in the third and fourth quarters with a towel over his head and without his helmet.
A surprise addition to the injury report, Eagles star Saquon Barkley missed practice Monday with a knee issue. However, NFL Network reports that Barkley is dealing with "general soreness" and is expected to play Thursday vs. the Giants.
The Eagles are coming off their first loss of the season, a 21-17 defeat by the hands of the Denver Broncos in which Barkley broke off a 47-yard catch-and-run touchdown.
Commanders coach Dan Quinn said he's "optimistic" about Terry McLaurin's chances to return for Week 6 against the Bears. McLaurin has missed the past two games with a quad injury.
"We're optimistic, and we'll have more information as the week goes on to see where they're at with [him] and Noah [Brown] and Sam Cosmi and a few other guys that are kind of trending in the right way," Quinn said. "We'll make sure we take all the right steps, just like we do with all the guys."
Quinn said having an extra day of rest -- the Commanders play on Monday Night Football -- "never hurts," but a decision won't come for another few days.
