After eight underdogs won outright in Week 1, bettors are looking at the Week 2 NFL odds and scratching their heads. In the opening week, there were no games that closed with double-digit lines, but there are four games with Week 2 NFL spreads of 10-plus points at Caesars Sportsbook. That includes Packers vs. Lions in Green Bay, with the home team favored by 11 in the latest Week 2 NFL Vegas odds.
The Lions are coming off an eight-point loss to the 49ers in which they overcame a 38-10 deficit in the final 20 minutes and had a chance to tie late, while the Packers were drilled 38-3 by the Saints. Should you back the Packers with your Week 2 NFL picks? All of the NFL lines are listed below, and before placing any NFL bets on these games or others, be sure to see the Week 2 NFL predictions from the proven computer model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Top Week 2 NFL predictions
One of the top Week 2 NFL predictions the model recommends: The Falcons (+12.5) stay within the spread against the Buccaneers. The Buccaneers began their season in style with a late Tom Brady drive culminating in a 36-yard Ryan Succop field goal as time expired to secure a 31-29 win. However, Tampa Bay was favored by nine, so they failed to cover.
The Falcons were blown out by the Eagles, but it seems unlikely that an offense with Matt Ryan, Calvin Ridley, Kyle Pitts and Mike Davis will continue to struggle this badly. The Buccaneers gave up 391 yards through the air in their Week 1 win over the Cowboys and the Falcons.
The model predicts that Falcons wide receiver Calvin Ridley has six catches for 80 yards, while Matt Ryan throws for 250 yards. The Falcons hold the Buccaneers to fewer than 100 yards rushing in the game, which helps the Falcons cover in over 50 percent of simulations. The over (52) also hits well over 50 percent of the time.
Another one of the top Week 2 NFL picks from the model: The Bears (-2.5) cover the spread at home against the Bengals. Chicago struggled to get anything going on offense against the Rams last Sunday night, finishing with just 14 points behind Andy Dalton's mediocre play. Dalton completed 27-of-38 passes for 206 yards, zero touchdowns and one interception.
The lone bright spot on Chicago's offense was running back David Montgomery, who carried the ball 16 times for 108 yards and a touchdown. Montgomery averaged 6.8 yards per carry and will likely be featured early and often against Cincinnati's defense, which gave up over 400 yards of offense last week against the Vikings.
In addition, the Bengals have been abysmal on the road in recent years, winning just one of their last 20 games away from home. The Bears, meanwhile, are 5-0 against the spread in their last five games versus the AFC North. The model says Montgomery rushes the ball 15 times and averages nearly five yards per carry against the Bengals, resulting in Chicago covering the spread in over 50 percent of simulations.
How to make Week 2 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 2 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.
So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.
Week 2 NFL odds, spreads, lines
Sunday, Sept. 19
Bengals at Bears (-2.5, 45)
49ers at Eagles (-3, 50)
Falcons at Buccaneers (-12.5, 52)
Cowboys at Chargers (-3.5, 55.5)
Monday, Sept. 20