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The Philadelphia Eagles took care of business when they faced the Detroit Lions last season, notching a 44-6 blowout win. Philadelphia rushed for 236 yards, which was eight more than Detroit's offense generated overall. The Eagles will look for another dominant performance when the teams square off in a rematch on Sunday during the Week 1 NFL schedule. Detroit is a 5.5-point underdog in the latest Week 1 NFL odds at Caesars Sportsbook, one of the larger NFL spreads this week. Philadelphia bolstered its offense by acquiring star wide receiver A.J. Brown from Tennessee during the offseason, but does the addition of Brown create value on the Eagles in the Week 1 NFL Vegas odds? All of the Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. 

Now, it has turned its attention to the latest Week 1 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 1 NFL predictions

One of the top Week 1 NFL predictions the model recommends: The Vikings (-1.5) cover against the Packers in well over 50 percent of simulations. Minnesota also both won and covered in last year's home game against the Packers.

Much has been made about Green Bay losing Davante Adams, but it also lost its best pass-rusher, Za'Darius Smith. He had 26 sacks from 2019-20 before missing all but one game in 2021, and he ended up, in all places, with the rival Vikings. He knows Green Bay's scheme as well as anyone and will only add to a pass rush which accumulated the second-most sacks (51) last year. The model has the Vikings (+1.5) covering as home underdogs in well over 50 percent of simulations. See who else to back here.

Another one of its Week 1 NFL predictions: The Colts (-7) cover the spread on the road versus the Texans. Veteran quarterback Matt Ryan will make his debut with Indianapolis after spending the previous 14 years of his career in Atlanta. Ryan, who has made 222 career starts, is trying to help the Colts snap a streak of eight consecutive losses in season-openers.

He has an ideal matchup in Week 1, as Houston's secondary features two rookie starters. The Texans were unable to compete with the Colts last season, getting outscored 62-3 in the two meetings. They are going to struggle to slow down the defending NFL rushing champion, Jonathan Taylor, again this season.

Taylor tallied a league-leading 1,811 yards and also led the NFL in rushing touchdowns (18) while tying with Austin Ekeler for the most total touchdowns (20). The Colts are a strong defensive team as well, ranking second in takeaways and ninth in points allowed last year. They have covered the spread in seven of the last eight meetings between these teams, and SportsLine's model has them covering almost 60% of the time in the latest simulations for Sunday's game. See which other teams to pick here.

How to make Week 1 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 1 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,500 since its inception, and find out.

Week 1 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Sept. 11

Ravens at Jets (+6.5, 44)

Featured Game | New York Jets vs. Baltimore Ravens

Browns at Panthers (PK, 42)

Featured Game | Carolina Panthers vs. Cleveland Browns

Colts at Texans (+7, 45.5)

Featured Game | Houston Texans vs. Indianapolis Colts

Jaguars at Commanders (-3. 44)

Featured Game | Washington Commanders vs. Jacksonville Jaguars

Patriots at Dolphins (-3.5, 46)

Featured Game | Miami Dolphins vs. New England Patriots

Saints at Falcons (+5.5, 43.5)

Featured Game | Atlanta Falcons vs. New Orleans Saints

Eagles at Lions (+5.5, 48.5)

Featured Game | Detroit Lions vs. Philadelphia Eagles

Steelers at Bengals (-7, 44.5)

Featured Game | Cincinnati Bengals vs. Pittsburgh Steelers

49ers at Bears (+6.5, 40.5)

Featured Game | Chicago Bears vs. San Francisco 49ers

Packers at Vikings (-1.5, 46.5)

Featured Game | Minnesota Vikings vs. Green Bay Packers

Chiefs at Cardinals (+6.5, 54)

Featured Game | Arizona Cardinals vs. Kansas City Chiefs

Raiders at Chargers (-3.5, 52)

Featured Game | Los Angeles Chargers vs. Las Vegas Raiders

Giants at Titans (-5.5, 44)

Featured Game | Tennessee Titans vs. New York Giants

Buccaneers at Cowboys (+2.5, 50.5)

Featured Game | Dallas Cowboys vs. Tampa Bay Buccaneers

Monday, Sept. 12

Broncos at Seahawks (+6.5, 44)

Featured Game | Seattle Seahawks vs. Denver Broncos