Every team in the NFC North opened its 2021 NFL schedule with a loss. The same could have been true in the AFC East and AFC South had those divisions not had two of their teams playing each other in Week 1. All four AFC South teams will play outside of the division in Week 2 and all are underdogs again in the latest Week 2 NFL odds at Caesars Sportsbook. New England is the biggest favorite in the AFC East according to the latest NFL spreads at -6. The Patriots' opponent, the Jets, were outgained on offense by Carolina in Week 1 to the tune of 129 yards, but only lost 19-14.

Can you trust the Patriots and rookie quarterback Mac Jones in your NFL picks and NFL bets? All of the NFL lines are listed below, and before placing any NFL bets on these games or others, be sure to see the Week 2 NFL predictions from the proven computer model at SportsLine

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 2 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 2 NFL predictions

One of the top Week 2 NFL predictions the model recommends: The Falcons (+12.5) stay within the spread against the Buccaneers. The defending champs looked sloppy in their opener, as Tampa had four giveaways while allowing 29 points to the Cowboys. Dallas should have had even more points and possibly a win, but kicker Greg Zuerlein left seven points on the board by missing three attempts.

While Atlanta's dreadful Week 1 performance is a big reason for the 12.5-point spread, quarterback Matt Ryan usually rises to the occasion in these types of games. He is 6-2 against the spread in his career as a double-digit underdog and has gone 3-0 since 2019. This is the largest spread Ryan and the Falcons have gotten since being 14-point underdogs in 2019 against the Saints, a game Atlanta won outright.

The model has Ryan throwing for 250 yards. It projects Tampa to win straight-up almost 80 percent of the time, but Atlanta covers the 12.5-point spread in over 50 percent of simulations.

Another one of the top Week 2 NFL picks from the model: The Bears (-1.5) cover the spread at home against the Bengals. At this point, too much time has passed for Bears quarterback Andy Dalton to have any insight on the Bengals' defense, but that won't stop the mentions about his tenure in Cincinnati and how this is a personal game for him.

Even in a pedestrian game against the Rams last week, Dalton still completed nearly 73 percent of his passes. The Bengals were steady against the run last week, but they allowed Minnesota's Kirk Cousins to throw for more than 350 yards with two scores. SportsLine's model shows Dalton threatening for two touchdowns on Sunday, while running back David Montgomery will push for 15 carries. The Bears' potential to control the pace of the game makes them the pick to cover in well over 50 percent of simulations.

How to make Week 2 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 2 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.

Week 2 NFL odds, spreads, lines

Sunday, Sept. 19

Saints at Panthers (+3, 44.5)

Featured Game | Carolina Panthers vs. New Orleans Saints

Bengals at Bears (-1.5, 44.5)

Featured Game | Chicago Bears vs. Cincinnati Bengals

Texans at Browns (-13.5, 48)

Featured Game | Cleveland Browns vs. Houston Texans

Rams at Colts (+3.5, 48)

Featured Game | Indianapolis Colts vs. Los Angeles Rams

Broncos at Jaguars (+6, 45)

Featured Game | Jacksonville Jaguars vs. Denver Broncos

Bills at Dolphins (+3.5, 47.5)

Featured Game | Miami Dolphins vs. Buffalo Bills

Patriots at Jets (+6, 43)

Featured Game | New York Jets vs. New England Patriots

49ers at Eagles (-3, 49)

Featured Game | Philadelphia Eagles vs. San Francisco 49ers

Raiders at Steelers (-6, 46.5)

Featured Game | Pittsburgh Steelers vs. Las Vegas Raiders

Vikings at Cardinals (-3.5, 50.5)

Featured Game | Arizona Cardinals vs. Minnesota Vikings

Falcons at Buccaneers (-12.5, 51.5)

Featured Game | Tampa Bay Buccaneers vs. Atlanta Falcons

Titans at Seahawks (-6.5, 54)

Featured Game | Seattle Seahawks vs. Tennessee Titans

Cowboys at Chargers (-3, 55)

Featured Game | Los Angeles Chargers vs. Dallas Cowboys

Chiefs at Ravens (+3.5, 53.5)

Featured Game | Baltimore Ravens vs. Kansas City Chiefs

Monday, Sept. 20

Lions at Packers (-11.5, 48.5)

Featured Game | Green Bay Packers vs. Detroit Lions