There are still three NFL teams with no wins entering Week 4, and according to the latest NFL odds, each has a strong chance of a victory on Sunday. The Texans battle the Colts in an AFC South matchup at 1 p.m. ET. Indianapolis is a one-point home favorite in the current NFL odds after opening at -1.5. Meanwhile, Jon Gruden and the Raiders are 3-point favorites over the Browns. That line has moved half-a-point in Oakland's favor, and the over-under has seen slight movement from 44.5 to 45. And Josh Rosen will make his first start for the Cardinals, who are underdogs by a field goal to the Seahawks. With NFL odds and spreads constantly shifting, be sure to check out the NFL picks and predictions from SportsLine's advanced computer model.
SportsLine's proprietary computer model went 176-80 last season and beat over 95 percent of CBS Office Pool players in 2016 and '17. It also performed better than 98 percent of experts tracked by NFLPickWatch.com during that span. Additionally, it went 48-34 on A-rated picks against the spread last season, and $100 bettors who followed it the past two seasons are up nearly $4,000.
Now it has simulated every snap 10,000 times and its Week 4 NFL picks are in.
New Orleans has recovered well from a season-opening loss to the Buccaneers, pulling off back-to-back wins against the Browns and Falcons that came down to the wire. New York got on the board with a win over the Texans in Week 3, but the model is projecting the Giants' defense to struggle against a New Orleans team that is averaging 34.7 points and 442 yards.
The model projects Drew Brees to top 300 yards through the air and throw at least two touchdowns as the Saints cover the spread in almost 60 percent of simulations. Alvin Kamara goes for almost 150 yards from scrimmage and a touchdown in the Saints' last game before getting Mark Ingram back from suspension. Kamara had 15 receptions last Sunday in the Saints' overtime win against the Falcons. You can back the Under (52) as well because SportsLine's model says it hits in 58 percent of simulations.
Another one of the Week 4 NFL picks the model is extremely high on: the Seahawks (-3) cover with plenty of room to spare in Phoenix against the Cardinals.
The Cardinals are turning to rookie quarterback Josh Rosen after Sam Bradford produced just 400 yards, two touchdowns and four interceptions in three consecutive losses. Arizona ranks dead last in the NFL in passing yards and rushing yards and is averaging just 6.7 points per game. The Cardinals were shut out by the Rams in Week 2.
Meanwhile, Seattle is coming off an impressive home victory over the Cowboys. Seahawks quarterback Russell Wilson is projected to throw for well over 250 yards and a touchdown in Arizona, according to the model, while Doug Baldwin and Tyler Lockett combine for over 100 yards on eight receptions. The model projects Seattle to cover in almost 60 percent of simulations, while the Under (39) is a strong value as well because that also hits almost 60 percent of the time.
The model also has a strong pick you need to see for the AFC East showdown between the undefeated Dolphins and the Patriots, and is calling for a favored Super Bowl contender to get a huge scare at home.
What NFL picks can you make with confidence in Week 4? And what Super Bowl contender gets a huge scare? Check out the latest NFL odds below and then visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that has beaten 98 percent of experts over the past two years.
Philadelphia Eagles at Tennessee Titans (+3, 41)
Houston Texans at Indianapolis Colts (-1, 47.5)
Buffalo Bills at Green Bay Packers (-9.5, 44)
Detroit Lions at Dallas Cowboys (-3, 44)
New York Jets at Jacksonville Jaguars (-7.5, 39)
Miami Dolphins at New England Patriots (-6.5, 49)
Cincinnati Bengals at Atlanta Falcons (-3.5, 53)
Tampa Bay Buccaneers at Chicago Bears (-3, 46.5)
Seattle Seahawks at Arizona Cardinals (+3, 39)
Cleveland Browns at Oakland Raiders (-3, 44)
San Francisco 49ers at Los Angeles Chargers (-10, 46)
New Orleans Saints at New York Giants (+3, 52)
Baltimore Ravens at Pittsburgh Steelers (-3, 51)
Kansas City Chiefs at Denver Broncos (+4.5, 54.5)