The Week 6 NFL schedule will conclude on Monday Night Football when Tennessee hosts Buffalo. Caesars Sportsbook lists Buffalo as a 5.5-point road favorite in the latest Week 6 NFL odds. The Bills will have to avoid a letdown following their impressive win at Kansas City last Sunday. Tennessee bounced back from a loss to the Jets with a 37-19 win at Jacksonville and now faces one of the larger NFL spreads of the week.

Is Monday Night Football one of the Week 6 NFL lines that you should avoid? Or will Josh Allen lead his team to a fifth straight win? Whether you're thinking of making Week 6 NFL picks on these games or others, be sure to see the Week 6 NFL predictions from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 6 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 6 NFL predictions

One of the model's strongest Week 6 NFL picks is that the Broncos (-3.5) cover the spread against the Raiders in well over 50 percent of simulations. The Raiders' injury-riddled secondary faces Broncos quarterback Teddy Bridgewater, who is throwing the ball deep more than he ever has while still maintaining the best completion rate and overall performance of his career.

SportsLine's model projects a six-point Broncos win and has Denver covering the spread in well over 50 percent of simulations. That's the same mark the model gives the over, which cashes in well over 50 percent of simulations. The point total for the game is at 44, moving slightly after opening at 44.5.

Another one of its Week 6 NFL predictions: The Ravens (-3) cover against the Chargers well over 50 percent of the time. Baltimore picked up its fourth consecutive victory when it erased a 22-3 deficit against Indianapolis on Monday. Quarterback Lamar Jackson completed 37-of-43 pass attempts for a career-best 442 yards and four touchdowns. He has turned into one of the league's top passing quarterbacks through the first five weeks of the season.

Los Angeles has struggled in its recent visits to the Eastern Time Zone, going 1-3 in its last four trips. The Chargers have allowed the most rushing yards of any team in the NFL, which does not bode well against an explosive Baltimore offense. Los Angeles allowed 230 rushing yards against Cleveland and is being gashed for 157.6 rushing yards per game.

SportsLine's model is projecting Baltimore to run for nearly 150 yards, while Jackson is expected to throw for another 250. It will be difficult for Los Angeles to match those numbers, which is why the Ravens are covering this spread in well over 50 percent of simulations. 

How to make Week 6 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 6 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.

Week 6 NFL odds, spreads, lines

Sunday, Oct. 17

Dolphins at Jaguars (+3.5, 47)

Featured Game | Jacksonville Jaguars vs. Miami Dolphins

Texans at Colts (-10, 43)

Featured Game | Indianapolis Colts vs. Houston Texans

Packers at Bears (+4.5, 44)

Featured Game | Chicago Bears vs. Green Bay Packers

Chiefs at Washington (+6.5, 55.5)

Featured Game | Washington Football Team vs. Kansas City Chiefs

Vikings at Panthers (+1, 46)

Featured Game | Carolina Panthers vs. Minnesota Vikings

Chargers at Ravens (-3, 52)

Featured Game | Baltimore Ravens vs. Los Angeles Chargers

Bengals at Lions (+3.5, 47.5)

Featured Game | Detroit Lions vs. Cincinnati Bengals

Rams at Giants (+9.5, 48.5)

Featured Game | New York Giants vs. Los Angeles Rams

Cardinals at Browns (-3.5, 49.5)

Featured Game | Cleveland Browns vs. Arizona Cardinals

Raiders at Broncos (-3.5, 44)

Featured Game | Denver Broncos vs. Las Vegas Raiders

Cowboys at Patriots (+3.5, 51)

Featured Game | New England Patriots vs. Dallas Cowboys

Seahawks at Steelers (-5, 42.5)

Featured Game | Pittsburgh Steelers vs. Seattle Seahawks

Monday, Oct. 18

Bills at Titans (+5.5, 54)

Featured Game | Tennessee Titans vs. Buffalo Bills