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Fanatics Sportsbook has upgraded its Fanatics Sportsbook promo code yet again with the 2025 NFL season underway. The latest Fanatics Sportsbook promo code allows new users to take advantage of two offers at once, first earning $100 in Fan Cash with a $10 bet, while also earning up to $100 in back in FanCash every football gameday. Sports bettors can use part or all of their initial $100 in FanCash on the Sunday NFL slate, as well as make a daily wager to earn up to $100 back in FanCash if that bet loses. 

The Sunday NFL schedule is packed with a 13-game slate, and one of the SportsLine's model best bets that showcases better value on Fanatics Sportsbook than other betting sites is the Packers to defeat the Lions at -130 odds in the latest Week 1 NFL odds. The Packers are 1.5-point favorites, while the over/under is 45.5 points. Before locking in your Week 1 NFL picks on your favorite online sports betting sites like Fanatics, you'll also want to be sure to check out the top NFL betting picks from SportsLine's proven computer model. Use the latest Fanatics Sportsbook promo code to claim your $100 in bonus FanCash each football Game Day. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns. Now, the model has revealed its top Week 1 NFL best bets at Fanatics Sportsbook: 

Best Week 1 NFL picks at Fanatics Sportsbook: 

  • Packers money line vs. Lions (-130) 
  • Seahawks money line vs. 49ers (+115)
  • Commanders (-6) vs. Giants (-110)

Parlay these picks for +626 odds at Fanatics Sportsbook (odds subject to change). Claim your $100 in bonus FanCash each football Game Day now:

Packers money line vs. Lions (-130)

The Packers are clearly going all-in this year, as evidenced by trading for and signing Micah Parsons to a massive contract. Jordan Love enters his third NFL season as a starter, and Green Bay added another playmaker after drafting Matthew Golden in the first round of the 2025 NFL Draft. The Lions also lost both offensive coordinator Ben Johnson and defensive coordinator Aaron Glenn to head coaching positions this season, so there's no guarantee Detroit will duplicate its No. 1 seed in the NFC results from last year. The Packers have home-field advantage on Sunday, and Green Bay went 6-3 at Lambeau Field last year.

The model has the Packers over the Lions as one of its top top values, and that's being calculated at a price closer to -140 than -130. Fanatics Sportsbook offers one of the best numbers for the Packers among sportsbooks at -130 odds, making this an even stronger play at Fanatics than at other betting sites. Pick it at Fanatics, where new users can take advantage of multiple bonus offers, including $100 in FanCash with your first $10 bet:

Seahawks money line vs. 49ers (+115)

Similar to the Packers pick, this offers a play the model likes at a price better than many other sportsbooks. However, the most obvious difference is that the model is seeing better value in the underdog upsetting the favorite, which the oddsmakers would say is less likely to happen. The model's simulations have the Seahawks winning 58% of the time though, compared to the implied odds at +115 odds being 46.51%.

Sam Darnold makes his Seahawks debut, and he's been doubted before. Many expected the Vikings to struggle last season due to Darnold being the team's QB1, but Darnold made the Pro Bowl while throwing for 4,319 yards, finishing 10th in MVP voting and leading Minnesota to a 14-3 record. Seattle is home against the 49ers, who still aren't at full strength due to injuries. Fanatics Sportsbook is offering the Seahawks money line at one of the longest prices among sportsbooks, making Fanatics the place to make this wager with the latest Fanatics Sportsbook promo code, where you can get $100 in FanCash every football gameday. 

Commanders (-6) vs. Giants (-110)

The Commanders were one win away from reaching last year's Super Bowl, going from the No. 2 overall pick to the No. 2 team in the NFC. Jayden Daniels quickly adjusted to the NFL game as a rookie quarterback and excelled throughout the season, including two victories over the Giants. New York went 3-14 last season, and although it made improvements on the defense through the draft and at quarterback with Russell Wilson, the Giants still have one of the lowest over/under projections in the league this season at 5.5 wins. The model projects the Commanders to cover the spread in 60% of simulations, making it a strong option at Fanatics Sportsbook to capitalize on two different promotions to earn $100 in FanCash. 

Want more Week 1 NFL picks?

You've seen the model's Week 1 NFL best bets at Fanatics. Now, get against the spread, total and money-line picks for every Week 1 NFL game here, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:

You can also see Week 1 NFL picks from expert Mike Tierney, who is 61-37-3 (+2007) over his last 101 NFL ATS picks, has locked in his top Week 1 NFL picks. Visit SportsLine to see his best bets.