NFL Week 1 betting and fantasy live updates: Latest odds, info on line moves, injuries, advice and more

Week 1 is finally here and we couldn't be more excited here at CBS Sports! Optimism is everywhere as teams begin their quest for a Super Bowl title and fantasy owners everywhere think their team has what it takes to take home a title. And of course, daily fantasy contests go on all year long, so needless to say, there's a lot to break down.

We're here to track all the betting and fantasy angles you need to know in the run up to kickoff of the Sunday slate, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at Caesars Sportsbook and plenty more.

Here's a look at the NFL odds for each Week 1 game as of Saturday evening (6 p.m. ET):

Before you get to the latest buzz, let's make sure you have all the right tools to dominate Week 1:

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49ers bump up a full point vs. Lions. 

There's a lot of confidence building in the 49ers as they take on the Lions. On Sunday, they've shot up a full point to -9.5 just 30 minutes prior to kickoff. This comes after they jumped up from -8 to -8.5 on Saturday, so there's certainly some money coming in to juice that number. San Francisco is 5-2 ATS in their last seven games in September and is 7-3 ATS in their last 10 games in Week 1. 


Falcons move to over a field-goal favorite vs. Eagles

Atlanta began the week as a 3.5-point favorite, but that slipped down to -3 on Tuesday and held at that number throughout the week. With about 30 minutes until kickoff, however, the line has bumped back up to Falcons -3.5. Philadelphia is 1-9 ATS in their last 10 games in September and 0-4 ATS in their last four games as a road dog. As for the Falcons, they are 0-5 ATS in their last five games in Week 1. 


Texans inactives: Watson a healthy scratch, Miller ruled out
Inactives: QB Deshaun Watson (non-injury reasons), DB Lonnie Johnson Jr. (quadriceps) LB Kevin Pierre-Louis (thigh), DB Jimmy Moreland, RB Scottie Phillips, DL Jon Greenard (ankle), WR Anthony Miller (shoulder)

As expected, the Houston Texans will make quarterback Deshaun Watson a healthy scratch to begin the year as he continues to deal with his off-the-field legal issues along with his trade request. Meanwhile, wide receiver Anthony Miller -- who was acquired via trade this summer -- is inactive. He wasn't listed on the injury report this week, but he did suffer a shoulder injury during the preseason in mid-August. It's possible the Texans are easing him back into the offense before putting him in a game. 


Jaguars inactives: No surprises
Inactives: S Daniel Thomas, CB Tre Herndon, OL Walker Little, TE Jacob Hollister, DE/OLB Jordan Smith, DL Adam Gotsis, DL Jay Tufele

The Jaguars roll into Week 1 healthy on offense. Expect them to lean on James Robinson in the run game. The target pecking order in the pass game is harder to decipher at this time but Trevor Lawrence showed an excellent rapport with Laviska Shenault in the preseason. 

September 12, 2021, 4:17 PM

Panthers inactive: Carolina largely healthy heading into Week 1
Inactives: OL Deonte Brown, DT Phil Hoskins, DE Darryl Johnson, LB Clay Johnston, OL Michael Jordan, WR Shi Smith

The Panthers had no real injury concerns heading into the opener, making five players a healthy scratch to begin the year. Rookie receiver Shi Smith didn't practice all week due to a shoulder injury and was ruled out on Friday. 


Jets inactives: No Cole, No Perine
Inactives: RB Josh Adams RB La'Mical Perine LB Quincy Williams CB Jason Pinnock DL Jonathan Marshall WR Keelan Cole

It might not be a major surprise, but at one point this offseason the expectation was both Perine and Cole would be a component of the Jets offense in 2021. At least in Week 1, that won't be the case. This should give rookies RB Michael Carter and WR Eli Moore an opportunity to get involved in the offense as soon as the first week. 

September 12, 2021, 4:13 PM

Chargers inactives: Austin Ekeler good to go
Inactives: TE Tre' McKitty, QB Easton Stick, RB Joshua Kelley, LB Amen Ogbongbemiga, DB Trey Marshall

After battling a hamstring injury this week, star running back Austin Ekeler is active for the Chargers. Ekeler returned to practice on Friday and the coaching staff was optimistic that he'd be able to go for the opener. Now, he should be looked at as a clear RB1, albeit while facing a tough Washington front-seven. Elsewhere on t in the Chargers backfield, rookie Larry Rountree III is active over Joshua Kelley. 


Washington inactives: No Samuel, but no surprise
Inactives: TE Sammis Reyes, OT Saahdiq Charles, QB Kyle Allen, DE Shaka Toney, CB Darryl Roberts

The biggest bit of injury news for the Football Team came earlier this week when Washington placed free agent acquisition WR Curtis Samuel on the IR. Samuel was expected to make a major impact having already known OC Scott Turner's system from their days together in Carolina. In his absence, Washington could lean more heavily on Terry McLaurin and get rookie WR Dyami Brown involved in the offense sooner than anticipated. 

September 12, 2021, 4:09 PM

Cardinals inactives: No surprises
Inactives: RB Eno Benjamin, QB Chris Streveler, CB Luq Barcoo, CB Tay Gowan, OL Josh Miles

The Cardinals roll into Week 1 fully healthy and with a plan to move forward with a two-headed RB attack featuring Chase Edmonds and James Conner. 

September 12, 2021, 4:06 PM

Lions inactives: No surprises
Inactives: DE Levi Onwuzurike, OLB Julian Okwara, RB Jermar Jefferson, WR KhaDarel Hodge, WR Tom Kennedy, G Tommy Kraemer

Left tackle Taylor Decker is not on this list because he's already been placed on injured reserve due to a hand injury. Onwuzurike was the only injury-related inactive as the rookie defensive end was officially listed as questionable with a hip injury. 


Eagles inactives: Davion Taylor to miss opener
Inactives: C Landon Dickerson, CB Mac McCain, S Rodney McLeod, QB Gardner Minshew, LB Davion Taylor

McLeod and Dickerson were ruled out on Friday, so the most notable Eagles player ruled out on Sunday is linebacker Davion Tayor. He entered the weekend with a questionable designation due to a calf injury. After dealing with a knee ailment that limited him throughout the week of practice, guard Brandon Brooks will play and start for Philadelphia. 


Falcons inactives: No Gallman means more Davis
Inactives: RB Wayne Gallman, WR Frank Darby, QB Feleipe Franks, CB Darren Hall, DL Ta'Quon Graham

The big scratch here is recently-signed RB Wayne Gallman. The Falcons scooped him off waivers after final cuts to be the No. 2 behind Mike Davis but it looks like it might take him some time to get up to speed with the new offensive system. This means we'll be seeing the Falcons lean heavily on Davis and he could have one of the highest snap shares of any RB in Week 1.

September 12, 2021, 4:01 PM

Vikings inactives: Dantzler a healthy scratch
Inactives: QB Kellen Mond, CB Cameron Dantzler, LB Anthony Barr, T Christian Darrisaw, TE Ben Ellefson,  DT James Lynch, DE Patrick Jones II

The most notable name that's inactive for Minnesota is corner Cameron Dantzler. After starting in 10 of his 11 regular season games last season, he's a healthy scratch s the Vikings open up the 2021 season. Anthony Barr (knee) and Christian Darrisaw (groin) were ruled out on Friday. 


49ers inactives: Rookie Trey Sermon down
Inactives: DT Javon Kinlaw (knee), CB Emmanuel Moseley (knee), RB Trey Sermon, G Aaron Banks, CB Josh Norman

Rookie running back Trey Sermon will not make his regular-season debut today against the Lions with the 49ers electing to hold him out of Sunday's opener. Sermon was not listed on the Niners injury report at any point this week, which means he's a healthy scratch for Week 1. 


Colts inactives: Wentz, Nelson officially active
Inactives: OL Eric Fisher, OL Will Fries, OL Danny Pinter, CB Xavier Rhodes, DL Isaac Rochell, DL Kemoko Turay, CB Chris Wilcox

The Colts had already ruled out Fisher, Rhodes and Turay for this matchup. The good news is that both quarterback Carson Wentz and star guard Quenton Nelson are both officially active for this opener after they both missed the bulk of the summer due to foot injuries. 


Seahawks inactives: Collier to miss opener
Inactives: QB Jake Luton, CB Bless Austin, RB Alex Collins, C Dakoda Shepley, T Stone Forsythe,  DE L.J. Collier

The notable inactive for Seattle is defensive end L.J. Collier. The 26-year-old -- who started all 16 games for the Seahawks in 2020 -- was not on the injury report this week, meaning he's a healthy scratch for their opener against the Colts. 


Steelers inactives: Pittsburgh fully healthy heading into the opener
Inactives: QB Dwayne Haskins, CB Ahkello Witherspoon, LB Robert Spillane, OL Rashaad Coward, DE Isaiahh Loudermilk

Linebacker Alex Highsmith was taken off the injury report on Saturday, meaning the Steelers have their full complement of players heading into the opener. Cornerback Ahkello Witherspoon was acquired in a trade with the Seahawks back in early September and just took the practice field for the first time this week, so it's not too surprising to see him as a healthy scratch. 


Titans inactives: No surprises
Inactives: WR Cam Batson, WR Josh Reynolds, DB Chris Jackson, LB David Long, Jr OL Dillon Radunz, TE Tommy Hudson, OLB Rashad Weaver

No real surprises here for Tennessee as they gear up for their matchup against the Cardinals. Jackson, Hudson and Reynolds were all questionable for the contest after being limited this week in practice so their statuses aren't a total shock. Meanwhile, A.J. Brown -- who did not practice Wednesday of this week -- carried no injury designation heading into the opener and is a full go to begin the season. 


Bills inactives: Zach Moss to miss opener
LB Andre Smith, OL Tommy Doyle, DL Star Lotulelei, RB Zack Moss, DE Boogie Basham

The big news for Buffalo is that running back Zack Moss will not be suiting up for the opener against Pittsburgh. Moss was not on the injury report this week, meaning he's a healthy scratch for this contest. With him sidelined, Devin Singletary should see plenty of work in the Buffalo backfield. 


Bengals inactive: OT Fred Johnson down
CB Trae Waynes, CB Nick McCloud, OL D'Ante Smith, DT Tyler Shelvin, OT Fred Johnson

Cincinnati will be without swing tackle Fred Johnson today when they take on the Vikings. The Bengals backup offensive linemen include tackle Isaiah Price, guard Jackson Carman and center Trey Hill. 


Titans-Cardinals spread falls under field-goal

The Titans opened as a 2.5-point favorite back in the spring but bumped up to a field-goal favorite at -3 in early June and that mark held throughout the summer and the week leading up to their opener with Arizona. In the hours prior to kickoff, however, that mark has dipped back below a field goal at Titans -2.5. In their last five Week 1 games, Tennessee is 1-4 ATS and are also 1-5 ATS in their last six games in September. As for the Cardinals, they are 8-3-2 ATS in their last 13 games as a road underdog. 


Patriots-Dolphins line crosses key mark

The Patriots are now over a field-goal favorite against the Dolphins as these AFC East rivals open up their seasons at Gillette Stadium. New England moved to -3 at the time Mac Jones was named the starter back in early September and, just hours before he takes his first regular-season snap, the line has moved to Patriots -3.5. New England is 4-1 ATS in heir last five Week 1 games, but are 1-6 ATS in their last six games as a favorite. Meanwhile, the Dolphins are 5-2 ATS in their last seven Week 1 games and 4-1 ATS in their last five contests as a road dog. 


Austin Jackson cleared to play vs. Patriots

Dolphins starting left tackle Austin Jackson is at Gillette Stadium and is cleared to play today vs. Patriots, per Adam Beasley of Pro Football Network. Jackson had been sidelined this week due to COVID-19 but has crossed the necessary hurdles to suit up for the opener. 


Giants-Broncos total jumps back up

After taking a quick dip down to 41.5 on Saturday, the total for Giants-Broncos has jumped back to 42 on Sunday morning. That 42-point total is where this line opened back in the spring. It did tick up to 42.5 in August, but September has primarily seen it hold at 42 as it does just hours before kickoff. The Over is 8-3 in the Broncos last 11 games in Week 1. As for the Giants, the Under is 4-1 in their last five Week 1 games. 


Washington's momentum builds

We've officially reached a full swing in the odds in the Week 1 opener between the Los Angeles Chargers and Washington Football Team. Back when this line first opened in May, the Chargers stood as the favorites at -2. Fast forward to the first NFL Sunday of the season and Washington has bumped up to a -2 favorite. That surge in favor of Washington really began this week when the line was moved to a pick'em last Sunday. From there, Washington continued to see this line move in their favor, becoming a one-point favorite by mid-week and jumped up a full point on game day. 

In their last five meetings, the favorite is 4-0-1 ATS. Meanwhile, the Chargers are coming into this game 4-0 ATS in their last four games overall. As for Washington, they are 6-2 ATS in their last eight overall. 


Eagles-Falcons total rises 

After sitting at 48.5 since Thursday, the total for Eagles-Falcons jumped up a half-point to 49 on Sunday morning. This marks a pretty consistent rise for this Over/Under mark throughout the summer. Back in May it opened at 47.5 and held at 48 for the bulk of the summer before gaining steam this week. The Over is 4-1 in both the Eagles and Falcons last five games in September. In their last five meetings, however, the Under is 5-0. 


No COVID-19 issues for Week 1

Ian Rapoport of the NFL Network relays that there are no COVID-19 related issues for the Week 1 opener and all games are set to be played today. Full speed ahead! 


Need fantasy advice for Week 1? Well, we've got you covered on CBS Sports HQ! Just watch the video above for all the latest fantasy news, injuries and advice.

September 12, 2021, 1:57 PM

Odell Beckham Jr. to test knee prior to Browns vs. Chiefs

Adam Schefter of ESPN reports that Odell Beckham looked good at practice this week as the star receiver continues to recover from a torn ACL that knocked him out of last season. That said, Beckham has yet to take any full reps and hasn't had any contact throughout the summer, so the Browns want to see how he feels pre-game prior to making a decision on his playing status for this opener against the Chiefs. 


Week 1 is here and #AskFFT is back, as the Fantasy Football Today crew will be answering start/sit questions on Twitter until kickoff. Just use the hashtag #AskFFT.

September 12, 2021, 1:55 PM
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