NFL Week 2 betting and fantasy live updates: Latest odds and info on line moves, injuries and more

The storyline of Week 2 entering Sunday's slate has been injuries. Players ruled out ahead of gameday include a list of talented pass-catchers such as Michael Thomas, Chris Godwin, Kenny Golladay, A.J. Brown and George Kittle, plus plenty of other key players who are either out or were placed on injured reserve throughout the week. But the arrow on injuries isn't trending in the wrong direction for every team; for example, the Philadelphia Eagles are set to get multiple key players back in the starting lineup for their matchup with the Los Angeles Rams.

We're here to track all the betting and fantasy angles you need to know in the run up to kickoff of the Sunday slate, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at William Hill Sportsbook and plenty more.

Here's a look at the odds for each Week 2 game as of 12:55 p.m. ET Sunday:

Rams at Eagles (-2), O/U 46
Giants at Bears (-4.5), O/U 42.5
Jaguars at Titans (-7), O/U 44.5
Panthers at Buccaneers (-7.5), O/U 47
49ers (-7) at Jets, O/U 41.5
Bills (-5.5) at Dolphins, O/U 42.5
Broncos at Steelers (-6.5), O/U 41
Falcons at Cowboys (-3), O/U 53.5
Lions at Packers (-7), O/U 51
Vikings at Colts (-3.5), O/U 49
Washington at Cardinals (-7), O/U 46.5
Ravens (-7) at Texans, O/U 49.5
Chiefs (-8.5) at Chargers, O/U 47
Patriots at Seahawks (-4), O/U 45
Saints (-5.5) at Raiders, O/U 48.5

Before you get to the latest buzz, let's make sure you have all the right tools to dominate Week 2:

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That'll do it for our betting and fantasy live blog for Week 2. Good luck with your picks and lineups!

September 20, 2020, 5:04 PM

Lines holding steady

It appears every line is holding in place in the minutes before kickoff, with no changes since about 12:30 p.m. ET at William Hill Sportsbook. Our SportsLine experts have filed 68 picks for the Sunday/Monday NFL slate, and you can check them all out here.

September 20, 2020, 4:57 PM

Packers O-line in flux?

After Billy Turner was ruled active for today's matchup with the Lions, it was assumed he would get the start at right tackle. However, NFL Network's Tom Pelissero notes that it appears Rick Wagner could wind up at the position based on pregame warmups. Even with Turner avoiding the inactive list, it doesn't appear he's a lock to play.

September 20, 2020, 4:37 PM

SNF line resets to Seahawks -4

After dropping a half-point earlier on Sunday, the line in Patriots-Seahawks is back to Seahawks -4. Will it stay in that range, or will a late push on Bill Belichick as a clear underdog send the line to a field goal, or possibly further?

September 20, 2020, 4:34 PM

Packers continue to pick up steam

The Packers, who were sitting at -6 over the course of the weekend, were expected by some to see their line drop on gameday, but instead they've risen another half-point to -7 with about 30 minutes left to kickoff. This figures to be the ceiling for the Green Bay side of the line, and it wouldn't be surprising to see pros take +7 back on the Lions.

September 20, 2020, 4:32 PM

Bears, Bucs lines drop again

The Giants and Panthers are apparently continuing to gain steam as kickoff approaches, as both teams have knocked another half-point off the lines in their respective games. The Bears now sit at -4.5 after starting the day -5.5, while the Bucs are only -7.5 after beginning Sunday at -8.5.

September 20, 2020, 4:31 PM

Three-headed backfield for the Rams in Week 2

NFL Media's Mike Garafolo reports that Darrell Henderson should see more looks in the Rams backfield today against the Eagles. He only saw three carries in the opener against Dallas while rookie Cam Akers saw 14 rushes and Malcolm Brown carried the ball 18 times in the win. Los Angeles ideally wants to use all three backs equally today, per Garafolo. 

This seems like a headache waiting to happen for fantasy owners. Brown was a popular waiver claim this week, but if he's splitting touches with two other backs, it makes his two-touchdown performance in the opener less exciting. Akers is the guy I want to own in this backfield, but won't play him until the rookie starts to separate himself as the season progresses. 

Three lines tighten toward 'dogs

We also saw three lines move a half-point toward the underdog with about an hour left until kickoff. The Giants are now +5 in their road matchup against the Bears, the Panthers fell to +8 for their road matchup against the Bucs and the Jaguars, a team that opened as 11-point underdogs after their upset win in Week 1, are now all the way down to +7 in their meeting with the Titans in Nashville.

Two totals also saw a half-point swing, with Falcons-Cowboys falling to 53.5 and Bills-Dolphins rising to 42.5.

September 20, 2020, 4:08 PM

Packers gain a half-point vs. Lions

The late movement in Lions-Packers seems to be for the home team despite the slight split the other way earlier, as the Packers have moved up a half-point and are now 6.5-point favorites against Detroit. While most O-line injuries don't move the market, it's worth noting that both right tackles in this game entered the day questionable, yet only Green Bay's was made active.

September 20, 2020, 4:05 PM

Giants inactives: Jones gets all weapons back

Inactives: RB Wayne Gallman, DB Adrian Colbert, LB TJ Brunson, LB Carter Coughlin, OT Jackson Barton, TE Eric Tomlinson, DL RJ McIntosh

For the first time in his career, Daniel Jones will get to play with the full slate of Giants weapons now that Golden Tate (hamstring) will return to the lineup. That's right, there wasn't a single game last season where all of Saquon Barkley, Sterling Shepard, Darius Slayton, Evan Engram and Tate were on the field together at once. This is good news for Jones, of course, but the Giants face another difficult defense in Week 2.

September 20, 2020, 4:03 PM

Eagles gaining steam as favorites

After opening the week as three-point favorites, the Eagles saw the market plunge, with the Rams briefly favorites early in the week. But the home team settled as one-point favorites later in the week before beginning to pick up steam in the run up to kickoff. The Eagles are now two-point favorites in their matchup against the Rams and also -130 on the moneyline.

September 20, 2020, 4:03 PM

Colts inactives: Rock Ya-Sin a surprise inactive

Inactives TE Jack Doyle, QB Jacob Eason, DT Eli Ankou, WR Dezmon Patmon, LB E.J. Speed, and CB Rock Ya-Sin.

The NFL Network is reporting that Rock Ya-Sin has an illness and won't play today. He was not listed on the injury report so this is something that developed rather quickly. He played 92% of Indy's defensive snaps in the opener. Receiver Michael Pittman (toe) and  safety Julian Blackmon (knee) are active.

Panthers inactives: Already bad defense is shorthanded

Inactives: QB Will Grier, CB Stantley Thomas-Oliver, DE Shareef Miller, OG Dennis Daley, DE Yetur Gross-Matos, DT Kawann Short

The big news here is that the defense will be without key players including arguably their best defender overall -- Kawann Short. This defense already looked like one of -- if not -- the NFL's worst in Week 1. This is the game to get your Bucs skill players rolling and Tom Brady back in all lineups.

September 20, 2020, 3:58 PM

Dolphins inactives: Parker active

Inactives: RB/WR Malcolm Perry, OT Adam Pankey, DE Jason Strowbridge, LB Elandon Roberts, S Clayton Fejedelem

DeVante Parker is ready to roll after being listed as questionable with a hamstring injury, while Roberts remains in the concussion protocol.

September 20, 2020, 3:58 PM

Cowboys inactives: No Tyron Smith

Inactives: OT Tyron Smith, S Reggie Robinson, QB Ben DiNucci, OT Alex Light, and LB Rashad Smith.

The injuries just keep coming for Dallas and Tyron Smith (neck) is the latest to be sidelined. Now, the Cowboy will be down both starting tackles with RT La'el Collins (hip) on injured reserve. 

Falcons inactives: Matthews a go

Inactives: RB Qadree Ollison, OT John Wetzel, DE Charles Harris, DT Marlon Davidson, CB Kendall Sheffield

Left tackle Jake Matthews is active after being listed as questionable with a knee injury, but second-round rookie Marlon Davidson is sidelined as expected after drawing a questionable tag.

September 20, 2020, 3:54 PM

Titans inactives: Brown, Beasley out

Inactives: WR A.J. Brown, RB, Darrynton Evans, OLB Vic Beasley Jr., OLB Derrick Roberson, OG/C Jamil Douglas, TE Geoff Swaim, DT Isaiah Mack

The Titans will be down No. 1 WR A.J. Brown in this one. In Week 1, Brown was outtargeted and outproduced by WR Corey Davis. Although Davis is dealing with a minor hamstring injury that limited him in practice this week, he is expected to play on a full snap count this week and should garner a lot of passing game targets. Rookie RB Darrynton Evans was supposed to carve out a role behind Derrick Henry this season but injuries have hampered that. Beasley's absence is a slight knock on TEN pass rush.

September 20, 2020, 3:52 PM

Lions inactives: Vaitai out

Inactives: WR Kenny Golladay, CB Desmond Trufant, CB Chris Jones, OT Halapoulivaati Vaitai, TE Hunter Bryant, DT Nick Williams, DE Julian Okwara

While the absence of Golladay and Trufant, two key starters, was a given after both were ruled out heading into gameday, the Lions still held out hope that Vaitai would be able to play despite a questionable tag. However, the right tackle will take a seat for a key divisional matchup against the Packers.

September 20, 2020, 3:52 PM

Steelers inactives: First active game for Anthony McFarland

Steelers inactives: G David DeCastro, QB Joshua Dobbs, ILB Ulysees Gilbert III, DL Carlos Davis, and TE Zach Gentry.

A lot has been made about the Steelers backfield as the club is set to split the carries between James Conner and Benny Snell, but there may be another running back to add into this mix. 2020 fourth-round pick Anthony McFarland Jr. is active for the first time this season today. It's unlikely that he'll have a sizable role out of the gate, but it will be interesting to see if he's able to steal some carries at any point in this contest. If any injuries pop up above him on the depth chart, he could be a hot waiver add next week. 

Packers inactives: Turner a go

Inactives: QB Jordan Love, CB Parry Nickerson, LB Randy Ramsey, G Lane Taylor, TE Josiah Deguara, DL Kenny Clark 

Offensive lineman Billy Turner gets the green light after being listed as questionable on the final injury report, and he should line up on the right side of the O-line for Green Bay. 

September 20, 2020, 3:49 PM

Rams inactives: Offense at full strength

Inactives: RB Raymond Calais, WR Trishton Jackson, TE Bryce Hopkins, C Brian Allen, OL Tremayne Ancrhum, DL Eric Banks

These are the exact six inactives the Rams had in Week 1 vs. Dallas -- an excellent sign they came out of Week 1 looking great on the injury front. The offense will be at full strength again.

September 20, 2020, 3:48 PM

Eagles inactives: Welcome to 2020, Miles Sanders

Eagles inactives: QB Nate Sudfeld, WR Alshon Jeffery, RB Jason Huntley, DE Genard Avery, G Jamon Brown, and G Sua Opeta. 

While Miles Sanders and Lane Johnson returning are a bigger deal for the Eagles in Week 2, it's noteworthy that we may be on the doorstep of rookie quarterback Jalen Hurts' debut as he is active for this matchup against the Rams. Didn't take long for him to earn the backup role behind Carson Wentz. Sanders is a must-start now that he's back in the fold and he noted this week that he is "100 percent, ready to go." Lane Johnson adding stability to Philly's O-line cannot be overstated. 

Broncos inactives: Sutton a go

Inactives: RB Phillip Lindsay, WR Tyrie Cleveland, TE Albert Okwuegbunam, G Netane Muti, DT McTelvin Agim, OLB Anthony Chickillo, ILB Mark Barron

The big news for the Broncos is that Courtland Sutton is active as the No. 1 receiver tries to tough out a shoulder injury. Left tackle Garett Bolles is also active after being listed as questionable on Friday due to an elbow injury. 

September 20, 2020, 3:45 PM

Jets inactives: Jamison Crowder out

Inactives: WR Jamison Crowder, QB Joe Flacco, QB James Morgan, DL Bryce Huff, DL Jordan Willis, CB Nate Hairston

Crowder was just about the only source of offense for the Jets in Week 1 and now he's out and they get to face another elite defense in San Francisco. While this should mean more volume for the likes of Breshad Perriman and Chris Hogan, it's hard to trust any Jets WRs in fantasy right now -- or Sam Darnold for that matter.

September 20, 2020, 3:44 PM

Vikings inactives: Dantzler out

Inactives: WR Chad Beebe, OT Oli Udoh, DE Eddie Yarbrough, DT James Lynch, CB Cameron Dantzler, CB Harrison Hand

The Vikings ruled third-round rookie Cameron Dantzler out on Friday's injury report, but his absence wasn't enough for fifth-round rookie Harrison Hand to see the gameday active roster. Mike Hughes, Holton Hill and first-round rookie Jeff Gladney should serve as the team's top three corners in their matchup against the Colts.

September 20, 2020, 3:42 PM

49ers inactives: Hello Brandon Aiyuk and Mohamed Sanu

49ers inactives: TE George Kittle (knee), DE Dee Ford (neck), CB Jason Verrett (hamstring), OL Tom Compton, LB Demetrius Flannigan-Fowles, and QB C.J. Beathard. 

Not real surprises here on the actual inactive list. This means, however, that rookie receiver Brandon Aiyuk and Mohamed Sanu -- who recently signed with San Francisco -- will play today. Both are fascinating fantasy options and worth a look today in DFS. Aiyuk may have a bit more upside for season-long FLEX spots thanks to his familiarity with Jimmy Garoppolo and the 49ers offense. Sanu has familiarity with head coach Kyle Shanahan, but he'll need to gain a quick rapport with Garoppolo. 

Jaguars inactives: Westbrook sits

Inactives: QB Jake Luton, WR Dede Westbrook, TE Tyler Davis, DT Doug Costin, CB Josiah Scott, CB Luq Barcoo

Westbrook is inactive for a second straight week after starting 11 games for the Jaguars in 2019.

September 20, 2020, 3:39 PM

Bears inactives: No surprises here

Inactives: WR Ted Ginn Jr, CB Duke Shelley, LB Josh Woods, OG Arlington Hambright, WR Riley Ridley, LB Trevis Gibson

The big news here is that both Robert Quinn and Khalil Mack will play for the Bears after having injury designations this week in practice. Quinn is making his Chicago debut. This makes Chicago a very attractive D/ST against turnover-prone Giants QB Daniel Jones and another disastrous looking offensive line in New York. Ginn's absence could make for a heavier dosage of Anthony Miller.

September 20, 2020, 3:38 PM

Bills inactives: Short at linebacker

Inactives: QB Jake Fromm, RB T.J. Yeldon, TE Lee Smith, OL Ike Boettger, LB Tremaine Edmunds, LB Matt Milano, LB Delshawn Phillips

The Bills are operating without their top two linebackers after Edmunds and Milano were ruled out on Friday. Ryan Fitzpatrick and the Dolphins offense will look to take advantage of those absences in the middle of a strong Buffalo defense.

September 20, 2020, 3:36 PM

Bucs inactives: Tyler Johnson will not make NFL debut

Buccaneers inactives: DL Khalil Davis, OLB Cam Gill, WR Chris Godwin, QB Ryan Griffin, WR Tyler Johnson, CB Parnell Motley, and G Aaron Stinnie

With Chris Godwin already being ruled out, there was some question as to whether or not we'd see Tyler Johnson make his NFL debut. That won't happen as the rookie pass-catcher is inactive today. This makes Tampa Bay wideout Scotty Miller a really intriguing fantasy play today. Would absolutely find a spot for him in DFS and is an intriguing FLEX play as well. Had five receptions for 73 yards in the opener against New Orleans. 

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