NFL Week 3 betting, fantasy updates: Latest news on Justin Herbert, odds, line moves, injuries, lineup advice

We're keeping you locked into the betting and fantasy angles leading up to Sunday kickoff for Week 3

The third Sunday of the NFL season is about to get underway, and there's plenty of reasons to be excited heading into this slate. Points could be coming in bunches, as there are a few contests that have totals of 50 points or higher, headlined by the huge AFC East showdown between the Bills and Dolphins. Home dogs are at a premium this week as well, which should only add to the drama that's about to unfold.

We're here to track all the betting and fantasy angles you need to know as we rocket toward kickoff in Week 3, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at Caesars Sportsbook and plenty more.

Here's a look at the odds (as of 10:40 a.m. ET on Sunday) for the Week 3 slate:

Kansas City Chiefs (-5) at Indianapolis Colts, O/U 51
Detroit Lions at Minnesota Vikings (-6), O/U 52
Cincinnati Bengals (-6) at New York Jets, O/U 45.5
Baltimore Ravens (-2.5) at New England Patriots, O/U 44.5
Houston Texans at Chicago Bears (-3), O/U 39
New Orleans Saints (-2) at Carolina Panthers, O/U 41
Buffalo Bills (-4.5) at Miami Dolphins, O/U 53.5
Philadelphia Eagles (-6.5) at Washington Commanders, O/U 47.5
Las Vegas Raiders (-2) at Tennessee Titans, O/U 45.5
Jacksonville Jaguars at Los Angeles Chargers (-3.5), O/U 42.5
Atlanta Falcons at Seattle Seahawks (-1), O/U 43.5
Los Angeles Rams (-3.5) at Arizona Cardinals, O/U 48.5
Green Bay Packers at Tampa Bay Buccaneers (-1.5), O/U 42
San Francisco 49ers (-1.5) at Denver Broncos, O/U 44.5
Dallas Cowboys at New York Giants (-1), O/U 39 (Monday) 

Get the latest odds from Caesars Sportsbook and others for each Week 3 game, here.  

[Sep 25, 2022 at 12:48 pm ET · Tyler Sullivan]

Big Colts bet. A Nevada bettor put $100k on Colts ML vs. Chiefs at +200, according to Caesars Sportsbook.

Potential payout: $200k 

[Sep 25, 2022 at 12:26 pm ET · Tyler Sullivan]

Some New Yorker is bored. 

[Sep 25, 2022 at 12:03 pm ET · Tyler Sullivan]

No faith in Carson Wentz. As he gears up for a matchup against his former Eagles team, the public is banking on the Commanders QB to have at least one mishap. At Caesars Sportsbook, 97% of the bets on his INT prop are on him throwing an interception. 

[Sep 25, 2022 at 11:44 am ET · Tyler Sullivan]

Saints inactives: QB Jameis Winston and RB Alvin Kamara are both ACTIVE

[Sep 25, 2022 at 11:42 am ET · Tyler Sullivan]

Bengals inactives: RT La'el Collins and TE Hayden Hurts are both ACTIVE

[Sep 25, 2022 at 11:41 am ET · Tyler Sullivan]

Ravens inactives: Ravens rookie NT Travis Jones will make his NFL debut in Week 3. Tight end Nick Boyle is also active.

[Sep 25, 2022 at 11:40 am ET · Tyler Sullivan]

Patriots inactives: WR Jakobi Meyers and S Kyle Dugger officially OUT 

[Sep 25, 2022 at 11:38 am ET · Tyler Sullivan]

Lions inactives: RB D'Andre Swift (ankle), TE T.J. Hockenson (hip), C Frank Ragnow (foot) and DE Aidan Hutchinson (thigh) – all listed as questionable – are ACTIVE for Week 3 at Minnesota. 

[Sep 25, 2022 at 11:36 am ET · Tyler Sullivan]

Raiders inactives: Josh Jacobs officially ACTIVE.

[Sep 25, 2022 at 11:34 am ET · Tyler Sullivan]

Bills inactives: Jordan Poyer will not play in Buffalo's road matchup vs. Miami.

[Sep 25, 2022 at 11:31 am ET · Tyler Sullivan]

Big bet on New England. A bettor from Arizona put $110k on Patriots ML (+130) against the Ravens today, per Caesars Sportsbook. 

[Sep 25, 2022 at 11:29 am ET · Tyler Sullivan]

After digesting some of the Sunday morning splits at Caesars, here are a couple of contrarian same-game parlays I find interesting if you want to fade the public. 

Chiefs at Colts
Colts ML + Michael Pittman Jr. Over 70.5 receiving yards + Jonathan Taylor Over 88.5 rushing yards = +575

Bengals at Jets
Under 45 + Joe Mixon Over 75.5 rushing yards + Michael Carter Over 2.5 receptions = +580

[Sep 25, 2022 at 11:18 am ET · Tyler Sullivan]

Justin Herbert knee-jerk reaction? A Michigan bettor put $240 on the Chargers to be the lowest scoring team of the week at +8000, according to Caesars Sportsbook. 

Potential win: $19,200

[Sep 25, 2022 at 11:16 am ET · Tyler Sullivan]

Some splits on the totals from Caesars Sportsbook: 

81% of tickets and 87% of dollars wagered on the Bills-Dolphins 52 total is on the OVER
77% of tickets are on the OVER 52.5 total in Lions-Vikings, but 63% of the dollars wagered are on the UNDER
51% of tickets are on the UNDER 50 total in Chiefs-Colts, but 70% of the dollars wagered are on the OVER
73% of tickets and 96% of dollars wagered on the Bengals-Jets 45 total is on the OVER
52% of tickets and 81% of dollars wagered on the Jaguars-Chargers 47.5 total is on the UNDER