A wildly unpredictable NFL season surges on. Sunday of Week 5 will begin with the return of Tom Brady, who is set to make his season debut for the Patriots after serving his four-game Deflategate suspension, and it will end Monday with the likely absence of Cam Newton, who's still dealing with a concussion.
And so, the second quarter of the NFL season begins, when we find out which of the current favorites are nothing more than hot starters that will flame out in the weeks to come, when we find out which of the current underperforming teams still has some fight left in them to make a run at the postseason.
Earlier in the week, CBS Sports' John Breech took a look at the early odds for this week's slate of games. Now, let's get to the updated odds heading into the weekend.
Reminder: You can check all our NFL expert picks right here. Source for all odds: VegasInsider.com
Texans at Vikings (Opening line: Vikings -6; Monday line: Vikings -6).
Current line: Vikings -6.5. Feel confident about the Vikings, who should ride their dominant defense inside their own stadium against a turnover prone offense. Texans quarterback Brock Osweiler has thrown at least one pick in each of his four games with his new team. The Vikings' defense has totaled 11 takeaways to this point.
Plus, as Breech pointed out: "Minnesota is an NFC-best 10-3 ATS vs. AFC teams since 2013. The Texans are 4-9 straight-up against the NFC since the beginning of 2013."
Feel confident in the Vikings.
Titans at Dolphins (Opening line: Dolphins -4; Monday line: Dolphins -3.5).
Current line: Dolphins -3.5. No movement since Monday and, really, this is a crapshoot of a game. Both teams are 1-3. Both teams stink. I wouldn't feel confident betting on either team.
It's worth noting that the Titans are 5-13 ATS as a road underdog since 2013. That's the worst record in the AFC in that span.
Patriots at Browns (Opening line: Patriots -7.5; Monday line: Patriots -10).
Current line: Patriots -10.5. Wow, bettors are certainly expecting the Patriots to rout the Browns in Cleveland. The line is now at -10.5.
They're likely feeling confident because Tom Brady is returning from his four-game ban and is set to begin his Deflategate revenge tour. But it is Brady's first game back after a month-long break. The Patriots pass-catchers are also banged up. And nobody really has any idea which version of Gronk we'll get.
The Browns run the ball well (first in yards per game) and the Patriots aren't great at stopping the run (15th). Of course, the Browns running game won't matter if Brady is back in full force, because he's Tom freakin' Brady.
Jets at Steelers (Opening line: Steelers -6; Monday line: Steelers -6.5).
Current line: Steelers -7.5. It's not hard to see the logic in the Steelers winning by more than a touchdown at home. They're facing a 1-3 Jets team led by Ryan Fitzpatrick, who's been so bad that he's actually making Geno Smith look like a decent option. Fitzpatrick has thrown nine interceptions in his past two games and he'll be forced to keep pace with a Steelers team that just dropped 43 on the Chiefs defense -- the same defense that picked off Fitzpatrick six times two weeks ago.
Redskins at Ravens (Opening line: Ravens -4; Monday line: Ravens -3.5).
Current line: Ravens -3.5. The line stays put at -3.5 after some early movement. So, I'll leave you with what Breech wrote earlier this week:
Since the beginning of 2015, the Ravens are just 1-5-1 ATS as home favorites, a record that includes their Week 4 loss to the Raiders. On the other hand, the Redskins aren't exactly a road team you want to bet on. Since the beginning of 2013, Washington is just 10-15 ATS in all road games. This will be the Redskins' first trip to Baltimore since 2008, a city where they've never beaten the Ravens there (0-3).
With that being said, Cousins has looked much better in the past two weeks, posting 100-plus passer ratings in both of the Redskins' wins.
Eagles at Lions (Opening line: Lions -2.5; Monday line: Eagles -2.5).
Current line: Eagles -3. The line continued to move in the Eagles' favor after the 1-3 Lions were initially favored at home against the unbeaten Eagles, who are fresh off their bye week. Jim Schwartz, the architect of this dominant Eagles defense, gets a chance to take some revenge against his former team.
Remember when his Bills defense beat the Lions a couple seasons ago? He ended up getting carried off the field.
14-point lead blown and Jim Schwartz carried off the field like a hero. How gross is that, #Lions fans...? #Billspic.twitter.com/gWD6TOBnjW— Kevin Gehl (@KevinGehlTV) October 5, 2014
Bears at Colts (Opening line: Colts -5; Monday line: Colts -4.5).
Current line: Colts -4.5. A quick injury update that will have an impact on the game: Jay Cutler, who is still dealing with a sprained thumb, is listed as doubtful. So, that means the Bears will likely trot out Brian Hoyer as their starter again.
It's also worth noting that the Colts went to London just last weekend. Most teams get a bye week after that trip, but the Colts aren't so lucky.
Falcons at Broncos (Opening line: Broncos -7; Monday line: Broncos -4.5).
Current line: Broncos -4.5. This might be the intriguing game of the week. Matt Ryan, the league's leading passer, helms the Falcons' top-ranked offense, but he'll go up against the vaunted Broncos defense in Denver. I'd expect the Broncos to get after Ryan and make him uncomfortable in the pocket. Ryan's at least been human under pressure so far this season. According to Pro Football Focus, Ryan's passer rating is 136.4 when he's well protected but it drops to 93.5 when he is pressured.
As Breech pointed out,"the Broncos are 15-3 straight-up against NFC teams since 2012 and are on a nine-game winning streak straight-up dating back to last season."
Bills at Rams (Opening line: Rams -1.5; Monday line: Rams -3).
Current line: Pick 'em. After the Rams got a slight bump at the beginning of the week, this is now a pick 'em game, with bettors piling on the Bills. So, who do you got?
The Bills have life after a 0-2 start, beating the Cardinals and Patriots in consecutive weeks. And the Rams are surprisingly sitting at 3-1 with Case Keenum as their quarterback. They've also been outscored by 13 points this season.
Adding to the Bills' momentum is the fact that three of the Rams' defensive linemen -- Robert Quinn, Will Hayes and Michael Brockers -- are all questionable for the game.
Chargers at Raiders (Opening line: Raiders -3.5; Monday line: Raiders -4.5).
Current line: Raiders -3.5. The Chargers are 1-3, but they should be 4-0. They've blown fourth-quarter leads in all three of their losses. Adding to their miserable season is the loss of No. 1 cornerback Jason Verrett, who landed on IR with a partially torn ACL this week.
The Raiders have been the Chargers' polar opposite so far, winning crazy close games.
The @RAIDERS are 1st team with to win two road games by exactly 1 point in their first 4 games since the merger— ESPN Stats & Info (@ESPNStatsInfo) October 2, 2016
So, expect a tight game and expect the Raiders to win it.
Bengals at Cowboys (Opening line: Bengals -1; Monday line: Pick 'em).
Current line: Bengals -2. Breech is our official Bengals' expert here at CBSSports.com, so allow him to explain why Andy Dalton might be money Sunday:
Since his rookie year in 2011, Dalton is 14-4-1 straight up against NFC teams. The Bengals have also been pretty strong ATS during Dalton's career, going 13-4-3 ATS, which is the best mark in the NFL since 2011.
But as Breech also pointed out, the Cowboys are 12-7-1 ATS against the AFC since 2011.
One aspect that's changed since the Monday line shifted to a pick 'em: Bengals tight end Tyler Eifert, who reached the end zone 13 times last season, will not play. He was expected to make his season debut this week after recovering from an ankle injury, but he ended up hurting his back.
Giants at Packers (Opening line: Packers -6.5; Monday line: Packers -7).
Current line: Packers -7. The Packers are coming off a bye week and the last time we saw them, they actually looked like a powerhouse -- for a half, at least. After jumping out to a huge lead over the Lions, the Packers had to hang on for a seven-point win. All three of the Packers' games (they're 2-1) have come down to a single score.
The Giants, on the other hand, are facing some adversity after their 2-0 start. They're 2-2 now and are dealing with the never-ending Odell Beckham Jr. drama. This week, it included Beckham owning up to his actions and coach Ben McAdoo getting into an argument during a radio appearance.
Buccaneers at Panthers (Opening line: Panthers -6; Monday line: Panthers -6).
Current line: Panthers -4.5. This is the important update: Cam Newton is reportedly not expected to play after suffering a concussion a week ago. So, it'll be Derek Anderson under center for the Panthers.
In relief of Newton last week, Anderson completed 17 of his 23 pass attempts for 172 yards and two touchdowns. He also tossed two interceptions.
Obviously, he's no Cam Newton, but he's been around for a while and has proved to be viable replacement in previous years. In 2014, Anderson started two games and led the Panthers to two wins. Funnily enough, both of those starts came against the Buccaneers. So, he'll at least be familiar with his foe.
The Buccaneers have lost three straight games. If not for Fitzpatrick's interception woes, more talk would be centered around Jameis Winston's own interception problems. He's thrown eight this season, which might be what end up dooming the Buccaneers on the road.
Still, it's worth noting: The Falcons just torched the Panthers defense for 48 points and 571 yards. So, he'll have a chance to tee off. And if he does, don't expect Anderson to keep pace.