NFL Week 6 betting and fantasy live updates: Latest odds and info on line moves, injuries and more

Week 6 is here, the first week of the season without a Thursday night game after Chiefs-Bills was pushed back to Monday to accommodate the Bills' delayed Week 5 game. Another delayed game is also on the slate for Sunday in Broncos-Patriots, with the two teams set to make up their postponed matchup from Week 5. That rescheduling has allowed both teams to welcome back their starting quarterbacks this week, with Cam Newton and Drew Lock set to square off rather than Brett Rypien(?) and Jarrett Stidham(?) or Brian Hoyer(?).

Other key games on the slate include a big AFC North battle when the Browns face the Steelers, a pair of big NFC battles in Packers-Buccaneers and Bears-Panthers, and a nightcap that has big implications for the NFC West with the Rams battling the 49ers.

We're here to track all the betting and fantasy angles you need to know in the run up to kickoff of the Sunday slate, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at William Hill Sportsbook and plenty more.

Here's a look at the odds for each Week 6 game as of Sunday at 12:55 p.m. ET:

Lions (-3) at Jaguars, O/U 53
Falcons at Vikings (-3.5), O/U 53.5
Washington at Giants (-1.5), O/U 42
Broncos at Patriots (-7), O/U 44
Texans at Titans (-3.5), O/U 52
Bears at Panthers (-2), O/U 45
Bengals at Colts (-7.5), O/U 46
Ravens (-10) at Eagles, O/U 46.5
Browns at Steelers (-3), O/U 50
Jets at Dolphins (-8.5), O/U 46.5
Packers (-2) at Buccaneers, O/U 54.5
Rams (-2.5) at 49ers, O/U 51
Chiefs (-5) at Bills, O/U 57
Cardinals (-1) at Cowboys, O/U 55.5

Before you get to the latest buzz, let's make sure you have all the right tools to dominate Week 6:

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That's going to do it for our pregame coverage of the fantasy and betting angles to know for Week 6. Thanks for joining us!

October 18, 2020, 5:02 PM

Line shifts towards Giants late

With only a few minutes left before kickoff, the line in Washington-Giants has moved back toward the favorite a half-point, with the Giants checking in at -1.5. They had been as high as -3 earlier in the week and sat at -2.5 for much of the week before dropping to -1 on Sunday. However, that looks to be as low as the market was willing to go in this matchup.

October 18, 2020, 4:56 PM

Packers gaining steam on Sunday

While the Packers-Bucs line got as low as a pick 'em earlier in the week, it's been on the rise toward the road team on Sunday. The Packers went from -1 to -1.5 about an hour ago and now have jumped another half-point to sit at -2. The Bucs will welcome Chris Godwin back to the lineup, setting Tom Brady up with the weapons he needs to keep pace with Aaron Rodgers and the Packers, but the market isn't buying it.

October 18, 2020, 4:34 PM

Patriots line continues to dip

The market has shifted the Patriots down to -7 with about 60 minutes left to kick, which could be an indication the books are desperate to get some New England money. If so, it's a stark contrast to the pre-2020 seasons where Patriots lines often appeared to be a point or two inflated, daring bettors to fade Bill Belichick's team.

October 18, 2020, 4:12 PM

Rams-49ers line dips under three

The line for the Sunday Night Football matchup has been Rams -3 or -3.5 all week, but on Sunday around noon ET it finally dipped lower, with the Rams sitting as 2.5-point favorites. The lookahead line for the matchup was actually 49ers -3 before they got blown out at home by the Dolphins, but it appears the market is finding value in the home 'dog after the massive adjustment.

October 18, 2020, 4:03 PM

Texans inactives: No Coutee or Akins

Inactives: WR Keke Coutee, RB Buddy Howell, TE Jordan Akins, CB Cornell Armstrong, OL Charlie Heck, LB Peter Kalambayi

The Texans remain without TE Jordan Akins so that means Darren Fells should be more involved in the passing game. He's still more of a desperation play at TE. Keke Coutee continues to miss time -- a story that has become too familiar in this career.

October 18, 2020, 4:00 PM

Washington inactives: Anderson active

Inactives: DE Nate Orchard, LB Thomas Davis Sr., QB Dwayne Haskins Jr., G Joshua Garnett, T David Sharpe, TE Marcus Baugh

Ryan Anderson is good to go after being listed as questionable, but the big news is that Washington is getting back guard Brandon Scherff after he was activated from injured reserve this week.

October 18, 2020, 3:58 PM

Panthers inactives: No Curtis Samuel

Inactives: QB Will Grier, WR Curtis Samuel, CB Eli Apple, G Dennis Daley, DT Woodrow Hamilton

Curtis Samuel was originally listed as questionable for this matchup after being a limited participant in practice all week, but a knee injury will sideline him for Week 6. In his absence, look for Seth Roberts to see an increased workload in the passing game. Corner Eli Apple, meanwhile, is out for the second-straight week with a hamstring injury. 

Bears inactives: Questionables cleared

Inactives: WR Riley Ridley, G Arlington Hambright, OLB Trevis Gipson, CB Duke Shelley, S Deon Bush

The Bears come into the matchup pretty healthy, with all three of their questionable players active for the game in OL Alex Bars (shoulder), DB Sherrick McManis (hamstring) and DE Brent Urban (knee).

October 18, 2020, 3:55 PM

Lions inactives: No surprises after the bye

Inactives: QB David Blough, CB Desmond Trufant, LB Elijah Lee, OL Logan Stenberg, OG Kenny Wiggins, WR Quintez Cephus

The Lions come out of their bye week relatively healthy with the exception of their CB situation -- an area Jacksonville will attack. On offense, there aren't any surprises.

October 18, 2020, 3:53 PM

Steelers inactives: No Johnson or DeCastro

Inactives: QB Josh Dobbs, WR Diontae Johnson, LB Ulysees Gilbert III, G David DeCastro, DT Carlos Davis, TE Zach Gentry

Both Johnson and DeCastro were ruled out for Week 6 on Friday so there really aren't that many surprises here. With Johnson out, however, that opens up even more opportunity for rookie receiver Chase Claypool to build off of his four-touchdown performance in Week 5. 

Vikings inactives: No surprises

Inactives: RB Dalvin Cook, WR K.J. Osborn, G Dru Samia, CB Kris Boyd, CB Holton Hill

The Vikings listed four players as out and one as doubtful on their final injury report, and all five make their way to the inactive list. Alexander Mattison with handle lead back duties with Cook sidelined.

October 18, 2020, 3:52 PM

Bengals inactives: Tate out as expected

Inactives: WR Auden Tate, RB Trayveon Williams, G Keaton Sutherland, LB Markus Bailey, K Austin Seibert

The Bengals will be without Tate after the receiver was listed as doubtful on the team's final injury report, but corner Mackensie Alexander is good to go after earning a questionable tag.

October 18, 2020, 3:49 PM

Browns inactives: Mayfield, Beckham and Landry good to go

Inactives: S Ronnie Harrison Jr., S Karl Joseph, LB Jacob Phillips, G Wyatt Teller, DE Joe Jackson, DE Vincent Taylor

Cleveland will have three key pieces to its offense ready to roll on Sunday against Pittsburgh as Baker Mayfield, Odell Beckham Jr. and Jarvis Landry are officially active for Week 6. All three of those players were originally listed as questionable. The Browns also noted that they are expected to start Sheldrick Redwine at safety and Chris Hubbard at guard. 

Colts inactives: Castonzo back

Inactives: QB Jacob Eason, WR Daurice Fountain, WR Dezmon Patmon, TE Mo Alie-Cox, OT Chaz Green, DE Ron'Dell Carter, LB Darius Leonard

The Colts will have left tackle Anthony Castonzo back on the blind side protecting Philip Rivers after he missed last week's loss to the Browns. Other questionable players active for Sunday include edge rusher Justin Houston, running back Jordan Wilkins and defensive lineman Denico Autry. Star linebacker Darius Leonard, who was doubtful to play, remains out.

October 18, 2020, 3:46 PM

Titans inactives: Still no Wilson

Inactives: OL Daniel Munyer, OL Isaiah Wilson, DB Chris Jackson, DL Matt Dickerson, LB Will Compton

Despite playing on a short week, there are no major surprise inactives for the Titans. Having said that, they are still without their first-round pick offensive tackle Isaiah Wilson. He was expected to replace Jack Conklin right away. The Titans run game has not reached 2019 levels of efficiency yet this season and a post-Bill O'Brien Texans matchup isn't exactly the best-case scenario for Derrick Henry.

October 18, 2020, 3:46 PM

Ravens inactives: Miles Boykin to play

Inactives: QB Trace McSorley, WR Chris Moore, DB Anthony Levine, OL Trystan Colon-Castillo, OL Ben Bredeson, DE Derek Wolfe.

After being a limited participant in practice on Friday due to a thigh injury, receiver Miles Boykin will play on today vs. Philadelphia. Starting tackle Ronnie Stanley -- who was officially listed as questionable due to a shoulder injury -- is also good to go for Baltimore. 

Broncos inactives: Drew Lock returns

Inactives: QB Jeff Driskel, RB Melvin Gordon, WR KJ Hamler, TE Noah Fant, G Netane Muti, DL McTelvin Agim, Jeremiah Attaochu

The Broncos will have Drew Lock back under center as expected after the quarterback was questionable on the final injury report. He'll be backed up by Brett Rypien, as the TNF starter has beaten out Driskel for the No. 2 job. Running back Phillip Lindsay also returns, and he could be in line for a big role with Gordon out. 

October 18, 2020, 3:42 PM

Giants inactives: Shuffle in the secondary

Inactives: FS Adrian Colbert, ILB TJ Brunson, OT Jackson Barton, TE Eric Tomlinson, DE RJ McIntosh, OLB Lorenzo Carter

The Giants don't have any inactive surprises on the offensive side of the ball, but they will once again have to shuffle things in the secondary. Adrian Colbert has been a near every-snap safety for the Giants since taking over and he won't play this week. This means Julian Love (who was benched earlier this season) will return to replace Colbert. Chalk this one up as a positive for the Washington passing game.

October 18, 2020, 3:41 PM

Patriots inactives: Brian Hoyer demoted

Inactives: DL Carl Davis, DB Myles Bryant, RB J.J. Taylor, TE Dalton Keene, QB Brian Hoyer

There has officially been a change at quarterback behind Cam Newton as Jarrett Stidham will now be New England's backup while Brian Hoyer has been demoted to QB3. This comes after Hoyer was less than stellar against the Chiefs, which forced Bill Belichick to bench him in the second half for Stidham, who played solid under duress. 

Falcons inactives: Cominsky active

Inactives: RB Qadree Ollison, OT John Wetzel, DE Takk McKinley, CB Jordan Miller, S Jaylinn Hawkins

The Falcons will be without one of their edge rushers with McKinley out, but John Cominsky is good to go after being listed as questionable on the team's final injury report. Julio Jones is also back in action to give the passing game a boost.

October 18, 2020, 3:38 PM

Jaguars inactives: Chark will play

Inactives: DE Josh Allen, DT Abry Jones, CB Luq Barcooo, DT Daniel Ekuale, WR Dede Westbrook, QB Jake Luton

After suffering an injury that limited him in Week 5, DJ Chark Jr. is ready to roll for Week 6 against a Lions secondary where first-round pick Jeff Okudah has struggled. On paper, this is a great matchup for Chark, but it's important to note the risk of re-injury when considering him for your fantasy lineups.

October 18, 2020, 3:37 PM

Eagles inactives: DeSean Jackson out

Inactives: QB Nate Sudfeld, WR DeSean Jackson, WR Alshon Jeffery, S Marcus Epps, CB Avonte Maddox, LB Duke Riley, T Lane Johnson. 

While Jackson is ruled out for Sunday's matchup against the Ravens, the veteran receiver -- who has missed the previous three games due to a hamstring injury -- is reportedly eyeing a Week 7 return. Carson Wentz will continue to be without not only Jackson and Jeffery for this matchup, but starting tackle Lane Johnson. 

Panthers line gains full point

After opening at Panthers -2.5, the line for Bears-Panthers dropped gradually throughout the week until it was all the way down to Panthers -1 on Sunday morning. However, we've now seen some buyback on Carolina, as the line was back up to Panthers -2 with about 90 minutes left until kickoff.

October 18, 2020, 3:34 PM

Vikings dip back to opening line

After the line for Falcons-Vikings opened at Vikings -3.5, the market pushed it up to -4 by Wednesday, where it sat for the rest of the week. But on Sunday, the line was back to -3.5 as late action has presumably come in on the Falcons. The total is also continuing to decline, shedding another half-point after falling a full point earlier to now sit at 52.5

October 18, 2020, 3:05 PM

Washington-Giants line still moving

After already dipping from Giants -2.5 to Giants -1.5 earlier this morning, the line for Washington-Giants is on the move again, with Washington picking up another half point to sit as just one-point underdogs. Could this game fall to a pick 'em by kickoff? The total also rebounded slightly in this matchup, gaining a half-point to move to 42.5.

October 18, 2020, 3:03 PM

Totals falling back to earth

Including the Washington-Giants game discussed earlier, four Sunday totals have fallen a full point from where they sat on Saturday evening. Texans-Titans is down to 52.5, Falcons-Vikings is down to 53 and Lions-Jaguars is down to 53.5. Is this an indication that some sharp bettors are banking on this being the week scoring begins to normalize, finally slowing down from the point frenzy that's been the first five weeks of the season?

October 18, 2020, 2:59 PM

Market continues to buy Chiefs

Turning our attention to Monday, the Chiefs opened as 3.5-point favorites on the road against the Bills, but that line has been on the rise, getting to Chiefs -4.5 by Thursday. On Sunday, the line moved again, with the Chiefs now five-point favorites. At some point the market will decide a good Bills team represents some value in the matchup, but we'll see if the line has to balloon further for that to happen.

October 18, 2020, 2:57 PM

Patriots line continues to drop

The line for the rescheduled Broncos-Patriots was as high as Pats -10 earlier in the week with the news Cam Newton would be back under center, but since then it's been steadily falling, including moving from Pats -8 to -7.5 on Sunday morning. As of now, the Broncos are also the juiced side at -115 over at William Hill, though it would be surprising to see this line dip all the way to -7 and open up a nice window for bettors who got down on Broncos +10.

October 18, 2020, 2:54 PM

Healthy Browns push line down

With news that key Browns such as Baker Mayfield, Odell Beckham and Jarvis Landry are expected to face the Steelers on Sunday, the line for that matchup has dropped back down to Steelers -3 from -3.5. Cleveland will be looking for its first win in Pittsburgh since 2003, when Tim Couch outplayed Tommy Maddox in a 20-point win. The Browns are 5-10-1 ATS since that game, including a loss as one-point favorites last year.

October 18, 2020, 2:51 PM
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