The 2022 NFL season is already more than a quarter of the way complete, but don't you dare avert your gaze, because things are just starting to get good. This weekend's Week 6 slate is chock-full of spicy -- and unpredictable -- matchups, perhaps none more intriguing than the heavyweight clash that is Bills versus Chiefs.
As we do every week, we've collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them all in one place, so you can get picks against the spread from our CBS Sports experts, as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.
All NFL odds via Caesars Sportsbook.
Which picks can you make with confidence in Week 6? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up almost $7,000 for $100 players on top-rated NFL picks since its inception.
Panthers at Rams
Time: Sunday, 4:05 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Rams -9.5
"Carolina pulled the plug on the Matt Rhule era, firing the head coach after just two and a half seasons. Despite the coaching turnover (defensive coordinator Phil Snow and assistant special teams coach Ed Foley were also fired), this could be a nice rebound spot for the Panthers. In these situations, teams do get a little boost the following game and Carolina now faces a Rams team that has struggled mightily to begin the season. Offensively, L.A.'s 4.8 yards-per-play average is tied for the lowest in the NFL and they are pressuring the QB on just 24% of plays, which ranks 31st in the NFL. ... This is a good spot to take the points."
CBS Sports' Tyler Sullivan is picking the Rams to win but the Panthers to cover in this potentially ugly slugfest between two desperate teams. Catch more of Sully's analysis, and predictions for every other Week 6 game, right here.
Cardinals at Seahawks
Time: Sunday, 4:05 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Cardinals -2.5
Geno Smith is, statistically, one of the most efficient QBs in the NFL right now. Kyler Murray, despite all his talent, is most definitely not. And yet the Cardinals are favored on the road in this divisional matchup. Don't buy it, says SportsLine expert R.J. White, who's tabbed Seattle as one of his SuperContest picks for Week 6. R.J. knows his stuff -- he's 329-250-21 all-time in SuperContest predictions, and once for tied for 17th out of almost 2,800 contestants in the Westgate Las Vegas competition -- so you've got plenty of reason to trust him leaning the Seahawks' way.
R.J. has more on Seattle, plus four other SuperContest picks for Week 6, at SportsLine right here.
Bills at Chiefs
Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open: PK
"I can't say this for sure, but I feel like the Bills' entire offseason plan revolved around one thing: Adding players who could help them beat the Chiefs. Their biggest signing was Von Miller, who was brought in for this exact type of game. He's someone who should be able to get some pressure on Patrick Mahomes, which is something the Bills didn't do a good job of in January. To me, this feels like a revenge game. ... All the Bills have been thinking about all offseason is 13 seconds. They were 13 seconds away from an AFC title game appearance, they were 13 seconds away from finally beating Patrick Mahomes in the playoffs and now, I'm 13 seconds away from making my prediction for the game. The Bills are an unstoppable freight train right now."
CBS Sports NFL analyst John Breech knows Mahomes probably deserves more credit, being a home underdog in such a big spot, but he's all over Buffalo in this rematch of last year's Divisional Round shootout. Check out all of his Week 6 picks here.
Cowboys at Eagles
Time: Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)
Open: Eagles -5.5
NFL expert Emory Hunt Jr., founder of Football Gameplan and former Louisiana-Lafayette running back, knows exactly how to read the Eagles, who enter "Sunday Night Football" looking to stay unbeaten. He's 36-21-1 in his last 58 picks involving Philly, returning $1,271 to bettors. He knows the Birds have one of the most balanced offenses in the game, but he's also not shortchanging the Dallas defense in this one. We can tell you Hunt is leaning Over for this prime-time NFC East brawl, but he's got a full forecast for the matchup, including an exclusive ATS projection, right here at SportsLine.
Broncos at Chargers
Time: Monday, 8:15 p.m. ET (ESPN), stream on fuboTV (try for free)
Open: Chargers -4
It's hard to know exactly what to make of the Chargers at any given time. Justin Herbert and Austin Ekeler are constant producers, but Brandon Staley's decision-making, no matter how analytically sound, has left plenty of fans scratching their heads during a 3-2 start. One guy who does have a solid handle on Los Angeles: SportsLine expert R.J. White, who is 17-6-1 in his last 24 ATS picks featuring the Chargers. The No. 1 ATS NFL expert on picks from 2017-2021, when he returned over $2,500 to $100 players, he's got a full breakdown of Monday night's matchup with Russell Wilson and the Broncos over at SportsLine. Check out his Over/Under call, plus a detailed ATS pick you'll wanna lock in, right here.
