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The San Francisco 49ers look to keep their hot start going when they match up against the Green Bay Packers on Sunday Night Football. The 49ers (2-0) entered Week 3 of the 2021 NFL season tied with the Los Angeles Rams and Arizona Cardinals atop the NFC West. Green Bay (1-1), meanwhile, sits atop the NFC North standings heading into Sunday's star-studded showdown. 

Kickoff from Levi's Stadium is set for 8:20 p.m. ET. The latest Packers vs. 49ers odds from Caesars Sportsbook lists San Francisco as three-point favorites, while the over-under sits at 50.5. Before locking in your 49ers vs. Packers picks, make sure you check out the NFL predictions and analysis from the proven SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,800 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 3 of the 2021 season on an incredible 122-81 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated Packers vs. 49ers 10,000 times and just revealed its NFL Week 3 picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Packers vs. 49ers:

  • Packers vs. 49ers spread: Packers +3
  • Packers vs. 49ers over-under: 50.5 points 
  • Packers vs. 49ers money line: Green Bay +145, San Francisco -170 
  • GB: The Packers are 8-2 against the spread in their last 10 games in September  
  • SF: The over is 5-1 in 49ers' last six games in Week 3 
Featured Game | San Francisco 49ers vs. Green Bay Packers

Why the Packers can cover

Green Bay's offense redeemed itself after a pitiful Week 1 performance. The Packers only recorded 229 yards of total offense in their season opening loss against the Saints. In Week 2, the Packers had 323 total yards of offense. The Packers also struggled on third down against the Saints, going 1-10. 

Quarterback Aaron Rodgers made sure that didn't happen two weeks in a row. Green Bay went 5-9 on third down against the Lions, helping keep the offense on the field. Running back Aaron Jones had 115 yards from scrimmage, getting it done on the ground and through the air. Jones scored four total touchdowns in Green Bay's 35-17 win over Detroit and he'll certainly be featured early and often against a San Francisco defense that's giving up 133.5 rushing yards per game this season.  

Why the 49ers can cover

Deebo Samuel is off to a strong start to the season. Samuel currently leads the league in receiving yards with 282 yards on 15 receptions with one score. In the season-opener, Samuel torched the Lions' secondary, reeling in nine catches for 182 yards. The 2019 second-round pick appears well on his way to establishing himself as one of the NFL's elite wide receivers.

Samuel has caught four passes of 20 or more yards, which is tied for second in the league. The former South Carolina Gamecock is averaging a league-high 141 receiving yards a game with a whopping 18.8 yards per reception. Samuel has the quickness and agility to make defenders miss in open space and could give Green Bay's secondary fits. 

How to make Packers vs 49ers picks 

SportsLine's model is leaning over on the point total, projecting the teams to combine for 49.5 points. In fact, it says Green Bay's Aaron Rodgers will throw for 230 yards and two touchdowns, while San Francisco quarterback Jimmy Garoppolo will throw for more than 200 yards with two touchdowns. The model also says one side of the spread has all the value. You can only see the model's Green Bay vs. San Francisco picks at SportsLine.

So who wins 49ers vs. Packers on Sunday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the 49ers vs. Packers spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and find out.