Panthers vs. Buccaneers odds, line: Thursday Night Football picks, predictions from top model on 79-49 run

The Carolina Panthers host the Tampa Bay Buccaneers in a key Week 2 matchup on Thursday Night Football. Each team looks to rebound from Week 1 losses, as the Panthers dropped a 30-27 home decision to the Rams and the Buccaneers fell 31-17 against the 49ers. Tampa Bay's game was more of a defensive battle that included three interception returns for touchdowns and neither team generating 300 yards of offense. Carolina's game was a shootout, led by a 200-yard, two-touchdown performance from running back Christian McCaffrey. Kickoff is set for 8:20 p.m. from Bank of America Stadium. Carolina opened as a five-point favorite, but the latest Panthers vs. Buccaneers odds have pushed the home team to -6.5. The over-under is 48 after early action on the under pushed it down from 50. You'll want to see what the SportsLine Projection Model has to say about the game before locking in any Buccaneers vs. Panthers picks.

This model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on its top-rated NFL picks since its inception four years ago. It has nailed its recent top-rated NFL picks, entering Week 2 of the 2019 NFL season on a sizzling 17-6 run that dates back to last season. It's also on a strong 79-49 roll on top-rated NFL picks that dates back to the 2017 season.

The model ranked inside the top 10 on NFLPickWatch for the third straight year on straight-up NFL picks and beat over 96 percent of CBS Sports office pool players. Anyone who has followed it is way up. 

Now, the model has honed in on Panthers vs. Bucs on Thursday Night Football. We can tell you it's leaning over, and it also says one side of the spread hits in almost 60 percent of simulations. That pick is available only at SportsLine. 

The model knows Newton didn't have his best game in Week 1, completing 65 percent of his passes for 239 yards, no touchdowns and one interception. However, a date with the Buccaneers' defense could be just what the doctor ordered. Last year, the unit allowed opposing quarterbacks to complete a league-high 72.5 percent of attempts. 49ers quarterback Jimmy Garoppolo completed 67 percent against the Bucs last Sunday. In last year's home game with the Buccaneers, Newton threw for 247 yards and two touchdowns, recording a QB rating of 133.3, his best mark all season.

Tampa Bay has failed to cover in five-straight Thursday Night Football games. The Buccaneers have not fared well on the road either, winning just one game each of the past two seasons.

But just because McCaffrey is poised for a big night doesn't mean Carolina will cover the Panthers vs. Buccaneers spread on Thursday Night Football.

Jameis Winston passed for only 194 yards with one touchdown and three interceptions in Week 1, but seven different players caught at least two receptions as he spread the ball around. Arians, who in five seasons in Arizona became the franchises' all-time winning coach, is known for his work with quarterbacks. Had two of Winston's picks not been returned for scores, the game's outcome may have been completely different, so look for a more-focused Winston against the Panthers.

Carolina has not fared well on Thursday Night Football, failing to cover in its last four appearances. The Panthers also haven't covered in their last four games against teams with a losing record. The road team has covered the spread in seven of the last 10 matchups between Carolina and Tampa Bay.

So who wins Buccaneers vs. Panthers? And which side of the spread hits in nearly 60 percent of simulations? Visit SportsLine now to see which side of the Buccaneers vs. Panthers spread to jump on Thursday night, all from the advanced model that is up more than $7,000 on its top-rated NFL picks.

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