The New York Giants will play host to the Los Angeles Rams at MetLife Stadium with these two NFC squads going toe to toe in Week 6. New York is coming into this matchup reeling following a loss to the Cowboys in Week 5 that saw a number of key players suffer injuries. Running back Saquon Barkley is set to miss this matchup due to an ankle injury. However, quarterback Daniel Jones, who departed due to a concussion, is slated to be ready to suit up. As for the Rams, they are well-rested after playing against the Seahawks last Thursday and walking away with a 26-17 win. 

In this space, we're going to dive into all the different betting angles that this game has to offer. We'll take a look at how the lines have shifted throughout the week, make our picks for Sunday's matchup and, of course, give you a few player props that catch our eye. 

All NFL odds via Caesars Sportsbook.

How to watch

Date: Sunday, Oct. 17 | Time: 1 p.m. ET
Location: MetLife Stadium (East Rutherford, New Jersey)
Fox | Stream: fuboTV (try for free)
Follow: CBS Sports App
Odds: Rams -9.5, O/U 48.5

Line movement

Latest Odds: New York Giants +7.5

Prior to the events of Week 5, this line opened at Rams -6.5, but quickly shot up to double-digits following the injuries that started to plague the Giants. This spread grew as high as Rams -10.5, but has since ticked down to Rams -9 as more positive news has continued to come out with Jones. 

The pick: Giants +9.5. This number is still inflated due to Jones' injury status so it's worth jumping on it sooner rather than later as I expect it to fall a bit once it's clear he'll suit up, which is expected. When healthy, Jones has played well this season, completing a career-high 64.3 percent of his passes. In the four full games he's played, he's 296 passing yards per game and has a passer rating of 98.3. Now that he's expected to play Sunday, getting a near double-digit cushion is a nice place to be against a Rams defense that even Geno Smith was able to throw on. L.A. is giving up 5.7 yards per play, which is middle of the road in the NFL

Key trend: Rams are 0-4 ATS vs. teams with a losing record. 

Over/Under total

The total has also rode the wave of the Giants' injuries. Originally, this total opened at 50, but sunk to 48 and dipped as low as 47.5 before climbing back up once Jones' status for Sunday became a bit clearer. The total rose as high as 49 midweek, but now sits at 48.5. 

The pick: Over 48.5. Both the Rams and Giants are inside the top 10 in the NFL in terms of pace, meaning they are quick to get to the line and, in theory, open up more scoring windows. While the Giants will in all likelihood have Jones in the fold, they will still be without some key weapons like Barkley. That said, rookie Kadarius Toney was extremely impressive in Week 5 and should be able to help the offense move the ball effectively for New York. Of course, we know the type of offense that is on the other side of the field in the Rams, who are averaging 28.2 points per game this season. 

Key trend: The Over is 6-1 in the Rams last seven games. 

Player props to consider

Robert Woods total receiving yards: Over 61.5 (-115). Woods is coming off a breakout game in Week 5 where Matthew Stafford targeted him 14 times and he rewarded him with 150 yards receiving. While it's unlikely that Woods will be force-fed in the same style as last week, that performance certainly warrants consistent looks going forward. 

Sony Michel total rushing yards; Over 25.5 (-115). You'll be rooting for Michel to get double-digit carries this week. In the three games this season where he's had 10 or more carries, he's gone over this number, including last week against the Seahawks. New York is also giving up 138.4 rushing yards per game this season. 

Devontae Booker total rushing yards: Over 46.5 (-115). He'll see a ton of work with Barkley out and doesn't have as bad of a matchup as you may think. L.A. is allowing 4.5 yards per carry this season, which is tied for sixth-most in the NFL.