The Los Angeles Rams (3-1) and Seattle Seahawks (2-2) will meet up for an NFC West showdown on Thursday Night Football. Both offenses are electric and have plenty of dynamic playmakers like Cooper Kupp, DK Metcalf, and Tyler Lockett. The Rams' offense has found plenty of success early in the year, averaging 398.5 yards and 28.8 points per game. Seattle is averaging 368 yards of total offense and 25.8 points per game. 

Kickoff from Lumen Field is at 8:20 p.m. ET. Los Angeles is a 2.5-point favorite in the latest Rams vs. Seahawks odds from Caesars Sportsbook, while the Over-Under is 53.5. Before locking in your Rams vs. Seahawks picks and NFL Week 5 predictions, make sure you check out the NFL analysis and insight from the proven SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated Rams vs. Seahawks 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see the model's picks. Here are several Week 5 NFL odds and betting lines for Rams vs. Seahawks:

  • Rams vs. Seahawks spread: Seattle +2.5 
  • Rams vs. Seahawks over-under: 53.5 points 
  • Rams vs. Seahawks money line: Los Angeles -135, Seattle +115 
  • LAR: Under is 7-1 in Rams' last eight games in October  
  • SEA: Seahawks are 8-1-2 against the spread in their last 11 Thursday games
Featured Game | Seattle Seahawks vs. Los Angeles Rams

Why the Rams can cover 

Quarterback Matthew Stafford has immediately played well for the Rams. Stafford is averaging 305.5 yards per game this season and has thrown for 1,222 yards with 11 touchdowns. The Georgia product has instantly clicked with receiver Cooper Kupp, who is one of the best pass-catchers in the NFL, hauling in 30 receptions for 431 yards with a league-high five touchdowns.

In the Wild Card matchup against Seattle, Kupp led the Rams with four catches for 78 yards and a touchdown. He also averaged 19.5 yards per reception. Kupp and Stafford are one of the top duos in the NFL and will attack Seattle's secondary, which is in the bottom five of the league against the pass (292.5 yards per game). 

Why the Seahawks can cover

Russell Wilson and the Seahawks have owned Thursday Night Football. Seattle has won nine straight on Thursday, and the Seahawks also have an astonishing 7-1-2 mark against the spread in this slot since Wilson joined the team. Wilson thrives on the challenge of the short week and should have the Seahawks ready to go.

Carson's status is a concern, but Seattle has a very capable backup in Alex Collins, who is averaging 5.9 yards per carry this season. Although Seattle's season-long defensive numbers aren't stellar, the Seahawks have played well in stretches. They gave up just 16 points against Indianapolis in Week 1 and held the 49ers to 2-of-14 on third down last week.

How to make Rams vs. Seahawks picks 

SportsLine's model is leaning under on the total, projecting the teams to combine for 49 points. It has also locked in a Seahawks vs. Rams against the spread pick that hits in well over 50 percent of simulations. You can only see the model's Rams vs. Seahawks picks at SportsLine.

So, who wins Rams vs. Seahawks on Thursday Night Football? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to see which side of the Rams vs. Seahawks spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and find out.