The Buffalo Bills, fresh off their possibly season-saving win over the Arizona Cardinals on Sunday, are about to start Patriots Week. Bills coach Rex Ryan has never been one to shy away from giving quotes before, especially in the lead-up to a game against his nemesis, Bill Belichick. (We can't call him Ryan's rival because, well, you have to beat a guy almost as many times as he beats you for him to be your rival. Ryan is now 4-11 against Belichick after starting his head coaching career 3-2 against him.)

This week, Ryan has an interesting challenge on his hands, because he'll be facing a Belichick-coached Patriots team without Tom Brady for the first time. Unsurprisingly, Rex does not care.

"I can sit back and say I don't care who plays quarterback, because (Tom) Brady ain't," Ryan said Sunday, per ESPN.com. "I don't care who plays quarterback. Steve Grogan can play quarterback. If (Bill) Belichick's playing quarterback, we're coming after him, I promise you that."

Ryan has always been an aggressive defensive coordinator, blitzing more than almost any coach in the league. Getting back to that strategy helped the Bills defeat the Cardinals on Sunday. Ryan sent extra rushers on 18 of Carson Palmer's 55 drop backs after blitzing only nine times on 39 drop backs against Ryan Fitzpatrick and the Jets the week before.

Putting extra men after in Palmer's face forced him into the kind of mistakes (four interceptions) Fitzpatrick didn't make at all the prior week. We'll have to see if Belichick keeps up a similar strategy against the Patriots, whether it's Jimmy Garoppolo, Jacoby Brissett, Julian Edelman, or some street free agent that isn't on the team yet that gets the start. It would be surprising to see Rex dial things back against any of them, considering their relatively inexperience at the position.