Well, this isn't good. Not only has Sammy Watkins been ruled out ahead of Sunday's game against the Patriots, but coach Rex Ryan said Friday that there's a "major concern" over Watkins' availability moving forward this season, according to ESPN.com.

Ryan added: "If this is something that is hurting this young man in any way, shape or form, then absolutely, I don't want him out there."

Watkins missed last week's game against the Cardinals -- incidentally, it was the Bills' first win of the season -- and in two previous appearances, the 2014 first-round pick managed just six receptions for 63 yards. He's yet to score a touchdown in 2016.

Following the Bills' Week 1 loss to the Ravens, CBS Sports NFL Insider Jason La Canfora reported that doctors had advised the wideout that there was no procedure he could undergo, but that it was simply a pain-threshold issue related to the screws that had been inserted in his foot.

Meanwhile, Watkins continues to fall short of his lofty draft pedigree. The Bills traded up from ninth to fourth to take him, even though they could have stayed put and landed Odell Beckham Jr.

We wrote about the decision at the time, and noted that Pro-Football-Reference.com's Career Average Value metric (CarAV) for the ninth pick and the fourth pick was virtually identical after the first few seasons, reinforcing the notion that the Bills were, well, flat out wrong to think that Watkins was worth it. The stats bear this out.

As it stands, Beckham is No. 2 among all 2014 draft picks in CarAV (behind only the Rams' Aaron Donald), while Watkins is ninth, tied with Buccaneers wideout Mike Evans, the 7th overall pick that year.

For now, the Bills' passing game will rely on Robert Woods and LeSean McCoy, who lead the team with 11 receptions each.