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The New Orleans Saints (6-7) and the Tampa Bay Buccaneers (10-3) will duel it out in a NFC South clash on Sunday Night Football. Tampa Bay is looking to win its fifth consecutive game as they inch closer to winning the NFC South for the second consecutive year. New Orleans, meanwhile, will look to sweep the season series as the Saints fight for a playoff spot in the competitive NFC. 

Kickoff from Raymond James Stadium is set for 8:20 p.m. ET. Tampa Bay is favored by 11-points in the latest Saints vs. Buccaneers odds from Caesars Sportsbook, while the over-under is 45. Before locking in any Buccaneers vs. Saints picks, make sure you check out the NFL predictions and betting advice from the SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Saints vs. Buccaneers 10,000 times and revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Saints vs. Buccaneers:

  • Saints vs. Buccaneers spread: Tampa Bay -11
  • Saints vs. Buccaneers over-under: 45 points 
  • Saints vs. Buccaneers money line: Tampa Bay -600, New Orleans +425
  • TB: The Buccaneers are 5-0 against the spread in their last five home games 
  • NO: The Saints are 6-1 against the spread in their last seven meetings
Featured Game | Tampa Bay Buccaneers vs. New Orleans Saints

Why the Buccaneers can cover

Tampa Bay's run defense has been stout all season long. The Buccaneers are currently ranked third and allow 91.2 rushing yards per game. This unit has allowed fewer than 100 yards rushing in seven games. Linebackers Devin White and Lavonte David have been superb in the middle of the defense. White leads the team with 110 total tackles, including 85 solo. 

The LSU product has also registered five tackles for loss with 3.5 sacks. The Louisiana native has logged double-digit stops in six games. In Week 10 against the Washington Football Team, White tallied a season-high 18 total tackles. Despite missing two games, David is second on the team with 86 total tackles. The Nebraska product has finished with at least seven total tackles in eight games thus far. 

Why the Saints can cover

New Orleans ended their five-game skid with a road victory against the New York Jets. The Saints' run game paid dividends in their win and the team finished with 203 rushing yards and 4.6 yards per rush. Running back Alvin Kamara returned to the starting lineup after missing four games with a knee injury. Kamara didn't miss a beat and ran for a team-high 120 yards on 27 carries with a score. 

The Tennessee product is one of the top backs in the game with lighting-quick speed and sure hands coming out of the backfield. Kamara leads the team with 173 carries for 650 yards and four scores. He has also reeled in 36 passes for 335 yards and another four touchdowns. The four-time Pro Bowl selection is averaging 109.4 scrimmage yards per game. 

How to make Saints vs. Buccaneers picks 

SportsLine's model is leaning over on the point total, projecting the teams to combine for 49 points. The model also says one side of the spread hits in 60 percent of simulations. You can only see the model's Saints vs. Buccaneers picks at SportsLine

So who wins Buccaneers vs. Saints on Sunday Night Football? And which side of the spread hits in 60 percent of simulations? Visit SportsLine now to see which side of the Buccaneers vs. Saints spread to jump on, all from the advanced model that is up almost $7,000 on its NFL picks, and find out.