The New Orleans Saints and the Carolina Panthers are set to square off in an NFC South matchup at 1 p.m. ET on Sunday at Bank of America Stadium. The Saints rolled to a 38-3 win over Green Bay in their season opener. The Panthers beat the Jets in Week 1, 19-14. 

The Saints have won the last four meetings between the teams. New Orleans is favored by three points in the latest Panthers vs. Saints odds from Caesars Sportsbook, and the over-under is set at 44.5. Before entering any Saints vs. Panthers picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP..

Now, the model has set its sights on Panthers vs. Saints. You can head to SportsLine to see its picks. Here are several NFL betting lines for Saints vs. Panthers:

  • Panthers vs. Saints spread: Saints -3
  • Panthers vs. Saints over-under: 44.5 points
Featured Game | Carolina Panthers vs. New Orleans Saints

What you need to know about the Panthers

Sam Darnold completed 24 of 35 attempts for 279 yards and passed for one TD with a rushing score in his Carolina debut, a win vs. his former team. Christian McCaffrey had nine receptions and 187 scrimmage yards, his 14th-career game with nine-plus receptions. He has 335 scrimmage yards in three career home games vs. the Saints. McCaffrey has averaged 103.9 scrimmage yards per game in his career in NFC South matchups. 

D.J. Moore has two-plus receiving TDs in two of his last three games vs, the Saints. Robby Anderson has averaged 5.1 catches per game as a Panther. Shaq Thompson has 10-plus tackles in his last two games vs. the Saints. 

What you need to know about the Saints

Jameis Winston passed for five TDs and 148 yards on 20 attempts in his first game as a Saint. It was the second time in his career he had five TD passes in a game. Winston threw a 55-yard TD pass to Deonte Harris in the fourth quarter. He has not thrown an interception in his last three games vs. the Panthers. 

Alvin Kamara has 16 receiving TDs since 2017, tied for first among running backs. He has four rushing TDs in three career games at Carolina. Sean Payton is 17-12 vs, the Panthers. 

How to make Saints vs. Panthers picks

The model has simulated Panthers vs. Saints 10,000 times and the results are in. The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Panthers vs. Saints? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.