The New Orleans Saints will try to take advantage of the Seattle Seahawks' misfortune on Monday Night Football. New Orleans (3-2) has had more than two weeks to recover and had won two of three before their bye. They beat Washington on Oct. 10 and took over second place in the NFC South when the Panthers lost to Minnesota in Week 6. The Seahawks (2-4) lost star quarterback Russell Wilson to a finger injury that required surgery and will once again rely on the arm of Geno Smith.

Kickoff is set for 8:15 p.m. ET at Seattle's Lumen Field. New Orleans is a 5.5-point favorite in the latest Saints vs. Seahawks odds from Caesars Sportsbook, and the Over-Under for total points scored is 41.5. Before locking in any Seahawks vs. Saints picks, you need to check out the NFL predictions and analysis from the red-hot SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,700 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 7 of the 2021 season on an incredible 125-85 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has broken down Saints vs. Seahawks on Monday Night Football and just released its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Seahawks vs. Saints on MNF:  

  • Saints vs. Seahawks spread: New Orleans -5.5
  • Saints vs. Seahawks over-under: 41.5 points 
  • Saints vs. Seahawks money line: New Orleans -240, Seattle +200
  • NO: Saints are 5-2 against the spread in the last seven meetings between the teams 
  • SEA: Under has hit in three of last four Seahawks games
Featured Game | Seattle Seahawks vs. New Orleans Saints

Why the Saints can cover

New Orleans has won the two most recent matchups, pulling off upsets in 2016 and 2019. It is well-rested and is 10-4 against the spread in its past 14 coming off a bye. Running back Alvin Kamara had 161 total yards and two TDs in the 2019 meeting and should be fired up to face this defense. The Seahawks rank last in the league in total yards (433 per game) and are yielding almost 141 on the ground (30th). Kamara has 482 yards and four scores this season. Quarterback Jameis Winston (892 yards, 12 TDs) also could take his shots against the 28th-ranked pass defense.

The Saints are 11-4-1 against the spread. Wide receiver Marquez Callaway is averaging 17 yards per catch, and the team will get Tre'Quan Smith back from a hamstring injury. The Saints are giving up just 18 points (fourth in NFL) and 79 rushing yards (second) per game. They have nine interceptions this season, and Cameron Jordan will harass Smith, who was sacked five times in his first start last week.

Why the Seahawks can cover

Smith has shown he can keep teams in games and is 5-1 against the spread in his career in primetime despite going 1-5 straight-up. He has excellent weapons outside, and the Saints rank 23rd against the pass, allowing 275 yards per game. DK Metcalf (441-5) and Tyler Lockett (441-3) form one of the league's best receiving duos, and tight ends Gerald Everett and Will Dissly have 10 catches apiece. The latter two could be relied on underneath as Smith faces a strong Saints front and tries to avoid an opportunistic secondary.

The underdog is 4-1 against the spread in the last five meetings and Seattle's defense should be able to focus on stopping running back Alvin Kamara. New Orleans ranks 31st in passing yards (169 per game), and QB Jameis Winston has been playing it safe so he can avoid the interceptions that plagued him in Tampa Bay. If he does throw, Seahawks safety Quandre Diggs (two interceptions) will be ready. Bobby Wagner is one of the NFL's best linebackers and shares the league lead with 72 tackles, while Jamal Adams has three tackles for loss and is always a disruptive presence.

How to make Saints vs. Seahawks picks

The model has crunched the numbers on Monday night's Seahawks vs. Saints matchup and is leaning over the point total. It also says that one side of the spread cashes in well over 50 percent of simulations. You can only see the model's Seahawks vs. Saints picks at SportsLine.

So who wins Seahawks vs. Saints on Monday Night Football? And which side of the spread cashes well over 50 percent of the time? Visit SportsLine now to see which side of the Seahawks vs. Saints spread you should be all over, all from the model on a 125-85 roll on its top-rated NFL picks, and find out.