San Francisco 49ers Week 17 score prediction vs. Seahawks

It's time for the 2016 San Francisco 49ers season to come to an end, but not before one last date with Seattle Seahawks (9-5-1). Here's a quick look at what we expect when the Seahawks come to Levi's Stadium on Sunday. 

When the Seahawks have the ball: Seattle is coming off a tough 34-31 defeat at the hands of the Arizona Cardinals in which they lost wide receiver Tyler Lockett to a broken tibia and fibula. They'll also quite possibly be without running back Thomas Rawls this week due to a shoulder injury, and given that the Seahawks are already without rookie C.J. Prosise (fractured scapula), rookie Alex Collins may be the main man at running back this week. Even a shorthanded Seahawks team will bring some threats though as quarterback Russell Wilson will still have Doug Baldwin, Jermaine Kearse and Jimmy Graham to throw to. The Seahawks offensive line continues to search for answers as they gave up six sacks against the Cardinals, five of them in the first half. The line has been a common problem for the Seahawks over the past two seasons but performed well in Seattle's 37-18 Week 3 win over San Francisco, something the 49ers will have to switch this week.

When the 49ers have the ball: In spite of the injuries listed above, the Seahawks have nothing on the 49ers when it comes to a banged up offense. Running back Carlos Hyde, wide receivers Torrey Smith and Quinton Patton, tight end Vance McDonald, and center Daniel Kilgore are all out, and tackle Joe Staley has missed three games with a hamstring injury. The 49ers managed to rally from behind despite that and come up with a win at Los Angeles last week, but coming up with a win against the Seahawks will be another matter. The offensive line will be challenged against a tough Seahawks front, while the 49ers may struggle to run the ball without Hyde. Colin Kaepernick will have his hands full with the Seattle pass defense, even without safety Earl Thomas, who is out for the year with a leg injury.

Prediction: The Seahawks have been an inconsistent team coming down the stretch, but they should still be able to get the job done this week. The 49ers haven't been too competitive against the Seahawks the past two seasons, and on paper, things still look a little lopsided given how many injuries the 49ers have on both sides of the ball. The Seahawks won't be overlooking this game in the least either as they need to win to keep their hopes alive of having a first-round bye in the playoffs. The 49ers could make a game of it for a while if the Seahawks continue to struggle up front and can't manage to run the ball, but in the end, the 49ers won't have enough firepower to pull this one out. Pick: Seattle 24, 49ers 16.

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