The Seattle Seahawks open the 2025 season at home against NFC West rivals, the San Francisco 49ers, on Sunday. Seattle finished 10-7 and just missed the playoffs in coach Mike Macdonald's first season, while the 49ers were a disappointing 6-11 a year after making a Super Bowl appearance. Sunday's game marks a potential return to action for San Francisco's star running back, Christian McCaffrey, while quarterback Sam Darnold makes his regular season debut for Seattle. The 49ers have won six of the last seven meetings, but fell most recently in a 20-17 final at home last November. Christian McCaffrey's name popped up on the injury report this week with a calf injury, but the superstar running back is active for San Francisco on Sunday.
Kickoff from Lumen Field in Seattle is set for 4:05 p.m. ET. San Francisco is a 1.5-point favorite in the latest 49ers vs. Seahawks odds from SportsLine consensus, while the over/under for total points scored is 43. The 49ers are -135 money line favorites (risk $135 to win $100), while the Seahawks are +114 underdogs. Before making any Seahawks vs. 49ers picks, make sure you check out the picks from the SportsLine projection model.
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Here are SportsLine model's best bets for Seahawks vs. 49ers on Sunday:
- Seahawks +1.5
- Over 43
Seahawks +1.5
Despite a winning record last season, the Seahawks were 1-5 against the spread as a home underdog in 2024. Both of these teams were worth fading on the betting line last year, with Seattle finishing 6-9-2 ATS and San Francisco 5-12 ATS. The 49ers may be depleted at receiver compared to last year, down Deebo Samuel (now in Washington) and Brandon Aiyuk (on the PUP list), but the potential return of Christian McCaffrey as their dual-purpose running back could be a benefit. Sam Darnold led the Vikings to the playoffs last season, and after getting a hefty payday this offseason, the quarterback has a nice supporting cast in Seattle. The Seahawks have two solid running backs, Kenneth Walker III and Zach Charbonnet, as well as receivers Jaxon Smith-Njigba and Cooper Kupp, as weapons. The SportsLine model has the Seahawks covering the spread as the home underdogs in 60% of simulations.
Over 43
Both of these teams hit the over more often than not in 2024, with the 49ers at 10-7 and the Seahawks at 9-8 favoring the higher scoring games relative to the oddsmakers' totals. In the last two seasons, three of the four matchups have gone over this number, including a 36-24 49ers victory on a Thursday night last October. The Over is hitting in 52% of simulations by the SportsLine model.
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