The Seattle Seahawks have gone three years without winning the NFC West after capturing the division crown three of the previous four seasons. They appeared on their way to ending the drought by winning their first five games of the 2020 NFL season but have hit a speed bump, losing three of their last four. Seattle hopes to get back on track when it hosts the division-rival Arizona Cardinals on Thursday Night Football. Kickoff from Lumen Field is scheduled for 8:20 p.m. ET. 

Seattle is a three-point favorite in the latest Seahawks vs. Cardinals odds from William Hill Sportsbook after the line opened at 5.5, while the over-under is 57. Before locking in any Cardinals vs. Seahawks picks, make sure you see the latest Thursday Night Football predictions from SportsLine's proven projection model.

The model, which simulates every NFL game 10,000 times, is up over $7,800 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 18-9 roll on top-rated NFL picks this season. The model enters Week 11 on an incredible 114-74 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Seahawks. You can visit SportsLine now to see the picks. Here are the NFL odds from William Hill and trends for Seahawks vs. Cardinals:

  • Seahawks vs. Cardinals spread: Seattle -3
  • Seahawks vs. Cardinals over-under: 57 points 
  • Seahawks vs. Cardinals money line: Seattle -160, Arizona +140
  • SEA: Seahawks are 1-5 against the spread in their last six divisional games
  • ARI: Cardinals have a point differential of plus-6.2

Why the Seahawks can cover

Russell Wilson had a standout game in Seattle's 37-34 overtime loss at Arizona in Week 7, completing 33-of-50 pass attempts for 388 yards and three touchdowns, all to wide receiver Tyler Lockett. The 31-year-old Wilson, who leads the NFL with 28 TD passes, has thrown for 27 scores and run for another in 17 career starts against the Cardinals. This year, he has recorded at least three touchdown tosses in his four home games. 

Lockett, who is battling a knee injury that coach Pete Carroll stated was not serious, leads Seattle with 58 receptions and is tied for sixth in the league with seven TD catches. Just ahead of him with eight is teammate DK Metcalf, who ranks third in the NFL with 816 yards. The Seahawks have the top scoring offense in the league (32.2 points) and are third in both total offense (405.9 yards) and pass offense (289.4).

Why the Cardinals can cover

Arizona, which trailed Buffalo 23-9 in the third quarter, had a 217-73 advantage in rushing yards. Kenyan Drake gained 100 yards on 16 carries to increase his season total to a team-high 612, 32 shy of the career-best he recorded in 2017 with Miami. Murray ran for 61 yards and a pair of touchdowns, while Chase Edmonds rushed eight times for 56 yards. 

Murray is second on the Cardinals in rushing with 604 yards and leads the NFL with an average of 6.9 per carry. The 2019 first overall draft pick ranks second in the league with 10 rushing touchdowns, which ties him with Johnny Lujack (1950) for most by a quarterback in his team's first nine games of a season. Murray also is the first signal-caller in the Super Bowl era and fourth in NFL history to run for a score in five consecutive contests.

How to make Seahawks vs. Cardinals picks

SportsLine's model is leaning under the total. In fact, it's calling for 55 total points. It also says one side of the spread hits over 50 percent of the time. You can only get the pick here.

So who wins Cardinals vs. Seahawks on Thursday Night Football? And which side of the spread hits over 50 percent the time? Visit SportsLine now to see which side of the Cardinals vs. Seahawks spread to jump on, all from the advanced model that is up more than $7,800 on its top-rated NFL picks, and find out.