The Arizona Cardinals will try to start the season 5-2 for just the third time since 1977 when they host the NFC West-leading Seattle Seahawks on Sunday Night Football at State Farm Stadium in Glendale, Ariz. Over the last 43 years, the franchise's best starts through seven games came in 2014 (6-1) and '15 (5-2). This year, the Cardinals (4-2) are tied for second in the NFC West behind the undefeated Seahawks (5-0). 

Kickoff is set for 8:20 p.m. ET. Seattle is a 3.5-point favorite in the latest Cardinals vs. Seahawks odds from William Hill, while the over-under for total points scored is 55. Before making any Seahawks vs. Cardinals picks, you need to see what SportsLine's resident Arizona expert, Zack Cimini, has to say

Cimini is a highly-respected Las Vegas handicapper who's never afraid to buck conventional wisdom. Over the 2018 and 2019 seasons, he hit 60 percent of his NFL expert picks for SportsLine members. He also has an uncanny feel for the tendencies of Arizona, going 9-1 on his last 10 against-the-spread NFL picks involving the Cardinals. Anyone who has followed him is way up.

Now, he has locked in on Cardinals vs. Seahawks and released a confident against-the-spread pick that is only available at SportsLine. Go here to see it. Here are the NFL odds and trends for Seahawks vs. Cardinals:

  • Seahawks vs. Cardinals spread: Seattle -3.5
  • Seahawks vs. Cardinals over-under: 55 points
  • Seahawks vs. Cardinals money line: Seattle -185, Arizona +165
  • SEA: QB Russell Wilson leads the league in passing touchdowns (19)
  • ARI: Cardinals rank second in scoring defense (18.7 points per game)

Why the Seahawks can cover

Seattle is great in primetime games. Since Pete Carroll took over as coach in 2010, the Seahawks are 31-7-1 under the lights, outscoring opponents 1,023-658. In addition, they are 11-4-1 on Sunday Night Football over that time. They already are 2-0 on Sunday nights this season.

In addition, Arizona's record may be a bit deceiving. The Cardinals have achieved their 4-2 record against teams that are a combined 11-24, having faced quarterbacks Jimmy Garoppolo, Dwayne Haskins, Matthew Stafford, Teddy Bridgewater, Joe Flacco and Andy Dalton. On Sunday Arizona will face a much stiffer test in MVP candidate Russell Wilson. 

Why the Cardinals can cover

Arizona has one of the best rushing attacks in the league. Led by running back Kenyan Drake and fleet-footed quarterback Kyler Murray, the Cardinals average 161.0 rushing yards per game. That ranks fourth in the NFL, only 8.5 yards shy of the top rushing team in the league, Cleveland.

In addition, the Arizona offense has a good matchup going against the Seattle defense. The Seahawks have allowed 1,852 pass yards (370.4 per game) this season, the most ever by a team in its first five games. They've also allowed 2,356 total yards (471.2 per game), the second most by a team in its first five games. Only the 1950 Colts (2,431 yards) allowed more. Arizona is reportedly expecting DeAndre Hopkins, who is officially listed as questionable with an ankle injury, to play. 

How to make Seahawks vs. Cardinals picks

Cimini is leaning over the total. He has also discovered a crucial x-factor that makes one side of the spread a must-back. He's only sharing it here.

Who wins Cardinals vs. Seahawks on Sunday Night Football? And what critical factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Seahawks vs. Cardinals spread you should jump on, all from the NFL expert who's 9-1 on Arizona picks, and find out.