Greg M. Cooper-USA TODAY Sports

Cam Newton makes his first road start as quarterback of the New England Patriots when they take on the Seattle Seahawks on Sunday Night Football at CenturyLink Field in Seattle. In last week's season opener against Miami, Newton completed 15-of-19 passes for 155 yards. He also rushed 15 times for 75 yards and two touchdowns. On Sunday night, he faces a Seattle defense that allowed the most yards per rush (5.98) to opposing quarterbacks in the NFL last season. 

Kickoff for Sunday Night Football is set for 8:20 p.m. ET. William Hill lists Seattle as a four-point favorite in the latest Seahawks vs. Patriots odds, while the over-under for total points scored is 45. Before you make any Patriots vs. Seahawks picks and NFL predictions for Sunday Night Football, make sure you see what SportsLine's resident Patriots expert, Stephen Oh, has to say.

The renowned co-founder of Accuscore, Oh simulates each game 10,000 times using the SportsLine Projection Model. Since the start of the 2018 season, he has nailed 36 of his 52 NFL picks against the spread, an incredible 69.2 percent success rate.

Oh is uncanny when it comes to these two teams. In fact, all-time, he is 14-6 on against the spread picks in games involving New England. In addition, he has hit five straight spread picks in games involving Seattle. Anyone who has followed him is way up.

Now, Oh has locked in on Patriots vs. Seahawks from every angle and released a confident against-the-spread pick. You can visit SportsLine now to see it. Here are several NFL lines from William Hill and trends for Seahawks vs. Patriots:

  • Patriots vs. Seahawks spread: Seattle -4
  • Patriots vs. Seahawks Over-Under: 45 points
  • Patriots vs. Seahawks moneyline: Seattle -200, New England +175
  • SEA: QB Russell Wilson completed 88.6 percent of his passes in Week 1.
  • NE: New England's defense had three interceptions last Sunday against Miami.

Why the Seahawks can cover

If Week 1 is any indication, Seattle is ready to let Wilson cook in 2020. In a pass-first attack that was a departure from recent seasons, Wilson completed 31-of-35 passes for 322 yards and four scores in the season-opening win over Atlanta.

Wilson had just as many touchdown passes as he did incompletions and connected with nine different receivers.

In addition, the Seahawks excel in primetime games. Since Pete Carroll took over as coach in 2010, Seattle is 29-7-1 under the lights, outscoring opponents 961-602. Plus, the Seahawks are 9-4-1 on Sunday Night Football during that span.

Why the Patriots can cover

New England has the ability to stop the Seattle run game. Last week the Patriots' new-look defense limited the Miami rushing attack to 3.2 yards per carry. Meanwhile, the Seahawks ran for just 84 yards on 20 carries against Atlanta, and 29 of those yards came from Wilson, who led the team in rushing. Neither Carlos Hyde nor Chris Carson averaged 4.0 yards per carry.

In addition, Seattle struggled to get pressure on Falcons quarterback Matt Ryan last week. The Seahawks pressured Ryan just 12 times in 54 pass attempts, and he still completed 10 of those passes for 111 yards.

How to make Patriots vs. Seahawks picks

Oh has analyzed this matchup and while we can tell you he's leaning over on the total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing it only at SportsLine

Who wins Seahawks vs. Patriots on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Patriots vs. Seahawks spread you should jump on, all from the NFL expert who's 14-6 on Patriots picks, and find out.