Two of the NFL's best quarterbacks will match up on Thursday Night Football in a nationally-televised clash. Veteran quarterback Matthew Stafford leads the Los Angeles Rams into Seattle to take on Russell Wilson and the Seahawks. Los Angeles is 3-1 this season, including an important win over the Tampa Bay Buccaneers in Week 3. Seattle is 2-2 in 2021 after a win over the San Francisco 49ers in Week 4.

Kickoff is at 8:20 p.m. ET in Seattle. Caesars Sportsbook lists the Rams as 2.5-point road favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 54.5 in the latest Rams vs. Seahawks odds. Before you make any Rams vs. Seahawks picks and NFL predictions, make sure you see what SportsLine NFL expert R.J. White has to say.

White, a CBS Sports fantasy and gambling editor, ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White has gone an astounding 35-17-1 on his last 53 picks involving Los Angeles, returning more than $1,500. Anyone who has followed him is way up.

Now, White has set his sights on Seahawks vs. Rams. You can head to SportsLine to see his picks. Now, here are several NFL betting lines and trends for Rams vs. Seahawks:

  • Seahawks vs. Rams spread: Rams -2.5
  • Seahawks vs. Rams over-under: 54.5 points
  • Seahawks vs. Rams money line: Rams -135, Seahawks +115
  • LAR: Over has hit in all four Rams games this season
  • SEA: Seahawks are 2-2 against the spread this season

Why the Rams can cover

The Seahawks are currently last in the NFL in total defense, allowing 1,778 total yards in four games. Seattle is No. 30 in the NFL in yards allowed per drive (41.3) and dead-last in first downs allowed with 107. The Seahawks are No. 28 in passing defense and No. 31 in rushing defense with an ugly 4.6 yards allowed per carry.

Los Angeles is a top-eight team in numerous categories, including points (28.8 per game). The Rams are No. 1 in the NFL in scoring efficiency and net yards per pass attempt in 2021. Quarterback Matthew Stafford, wide receiver Cooper Kupp and a dynamic passing game should enjoy success, building on a top-five passing mark of nearly 1,200 yards in four games.

Why the Seahawks can cover

The Seahawks are generating 37.6 yards per drive, a top-eight mark in the NFL, and lead the league in passer rating. Wide receiver Tyler Lockett produces more than 16 yards per carry, and the veteran is coming off back-to-back seasons with at least 1,000 receiving yards. DK Metcalf has also been productive, generating more than 70 yards per game, and has produced a first down on 14 of his 20 receptions in 2021.

Metcalf broke out with 1,303 yards and 10 touchdowns last season and is a dynamic pass-catcher. Los Angeles has also struggled defensively this season, giving up nearly 400 total yards per game with the No. 28 marks in first downs allowed with 100 in four games. The Rams have trouble getting off the field as well, allowing opponents to convert 50 percent of third down opportunities, ranking No. 29 through four weeks of action.

How to make Seahawks vs. Rams picks

White has analyzed this matchup and while we can tell you he's leaning over the total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and who to back, at SportsLine.

So who wins Rams vs. Seahawks on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see White's Rams vs. Seahawks picks, all from the NFL expert who's 35-17 on picks involving Los Angeles, and find out.